Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of Tianshan snow lotus wall-breaking preparation

A preparation, the technology of snow lotus, which is applied in the field of traditional Chinese medicine, can solve the problems of destroying active ingredients, loss of active ingredients, and easy moisture absorption, etc., and achieves improved utilization of active ingredients, good disintegration and stability, and simple granulation process Effect

Active Publication Date: 2018-03-16
ZHONGSHAN ZHONGZHI PHARMA GRP
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Mainly containing sesquiterpene lactones: such as guaiacrolactone, guaiacenolide-β-glucoside, yaconolide, sacralide; flavonoids; such as rutin, quercetin, etc. and phenolic Acid components: chlorogenic acid, etc., among which flavonoids and phenolic acids are relatively sensitive to temperature and have poor thermal stability
Therefore, if the traditional decocting method is adopted, it is easy to destroy its active ingredients or cause the loss of active ingredients.
The preparation of Tianshan Snow Lotus into Tianshan Snow Lotus superfine powder is beneficial to improve the utilization rate of active ingredients, but at the same time, due to the increase of powder specific surface area, it has the disadvantages of easy moisture absorption, oxidation, deterioration, etc.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of Tianshan snow lotus wall-breaking preparation
  • A kind of Tianshan snow lotus wall-breaking preparation
  • A kind of Tianshan snow lotus wall-breaking preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040]Take the medicinal material of Snow Lotus from Tianshan, coarsely crush it into a coarse powder of about 100 meshes, and then ultrafinely pulverize it into a powder in which 90% of the particles in the ultrafine powder have a particle size less than or equal to 45 μm, and add ethanol-water solution (the mass fraction of ethanol is 30%) Soft materials are made by wet method, the ratio of solution to superfine powder is 0.8:1 (by weight), after mixing, a 10-mesh sieve is pre-installed, the extrusion speed is 50r / min, and the extrusion force is 1MPa to make wet granules. The granules were transposed into a hot air circulation oven, the drying temperature was set at 75°C, and dried for 2.0 hours until dry.

[0041]

[0042] Note: The full score is 10.

Embodiment 2

[0044] Take the medicinal material of Snow Lotus from Tianshan, coarsely pulverize it into a coarse powder of about 100 meshes, and then superfinely pulverize it into a powder in which 90% of the particles in the superfine powder have a particle size less than or equal to 45 μm, and add ethanol-water solution (the mass fraction of ethanol is 40%) Soft materials are made by wet method, the ratio of solution to superfine powder is 0.9:1 (by weight), after mixing, a 10-mesh sieve is pre-installed, the extrusion speed is 60r / min, and the extrusion force is 1MPa to make wet granules. The granules were transposed into a vacuum microwave drying oven, the drying temperature was set at 45°C, and dried for 0.75h until dry.

[0045]

[0046] Note: The full score is 10.

Embodiment 3

[0048] Take the medicinal material of Snow Lotus from Tianshan, coarsely pulverize it into a coarse powder of about 100 mesh, and ultrafinely pulverize it into a powder with a particle size of 90% or less in the ultrafine powder, and add ethanol-water solution (the mass fraction of ethanol is 90%) Soft materials are made by wet method, the ratio of solution to superfine powder is 1.5:1 (by weight), after mixing, a 30-mesh sieve is pre-installed, the extrusion speed is 80r / min, and the extrusion force is 0.3MPa to make wet granules. The wet granules were placed in a hot air circulation oven, set the drying temperature at 75°C, dried for 1.5 hours until dry, and sieved to obtain the Tianshan Snow Lotus Broken Wall Preparation.

[0049]

[0050] Note: The full score is 10.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
quality scoreaaaaaaaaaa
Login to View More

Abstract

The invention relates to a traditional Chinese medicine preparation, in particular to a Tianshan snow lotus wall-breaking preparation. The invention crushes Snow Lotus of Tianshan Mountains into broken-wall powder, controls the quality of ethanol solution and broken-wall powder, carries out ethanol-water wet granulation, and extrudes at a certain speed, and dries, and the granulation rate of this method is high , the thus obtained Tianshan Saussurea sinensis wall-broken preparation has high bioavailability, and the preparation has strong stability and good disintegration.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a preparation for breaking the wall of Saussurea chinensis. Background technique [0002] Ultrafine pulverization technology is a new technology developed rapidly in recent years. Most of the active ingredients in Chinese herbal medicines are distributed in the cells. Conventional decoction pieces can only release part of the active ingredients, and the utilization rate of active ingredients is 10-30%. However, using the wall-breaking crushing technology, such as crushing Chinese herbal medicine pieces to 300 mesh About 86.7% of the cell wall breaking rate will increase the dissolution of the active ingredients in the medicinal materials, greatly enhance its efficacy, and the utilization rate of the active ingredients will be above 90%, so as to reduce the amount of medicinal materials used and protect the medicinal materials resources. The quality of the drug increas...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/10A61K36/285A61K9/16A61J3/00
Inventor 成金乐赖智填钱锦花徐吉银陈金梅
Owner ZHONGSHAN ZHONGZHI PHARMA GRP
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com