Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of benzimidazole zinc complex and preparation method thereof

A technology of benzimidazole zinc and benzimidazole, applied in the field of metal complex antitumor drugs, can solve the problems of difficult to meet the clinical needs of esophageal cancer treatment, many adverse reactions, easy to produce drug resistance, etc., and achieve the purpose of inhibiting esophageal cancer cells Ease of growth and post-treatment, good inhibitory effect on the growth and activity of esophageal cancer cells

Inactive Publication Date: 2017-01-25
ZHANJIANG NORMAL UNIV
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, platinum complexes such as cisplatin have the disadvantages of low selectivity, many adverse reactions, and easy drug resistance, which have been difficult to meet the clinical needs of esophageal cancer treatment.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of benzimidazole zinc complex and preparation method thereof
  • A kind of benzimidazole zinc complex and preparation method thereof
  • A kind of benzimidazole zinc complex and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] (1) Ligand 2-(2-(1H-benzimidazole-2-)benzyl)-1H-benzimidazole synthesis method

[0026] 2-(Carboxymethyl)benzoic acid (1.80g, 0.010mol) and o-phenylenediamine (2.16g, 0.020mmol) were mixed in phosphoric acid (20mL), heated at 180°C for 3 hours, and the reactant was cooled to room temperature, then Distilled water was added and a yellow solid was obtained after neutralization with ammonia water. Washed 3 times with distilled water, then filtered, and recrystallized from ethanol to obtain yellow-green solid 2-(2-(1H-benzimidazole-2-)benzyl)-1H-benzimidazole, the yield was 2.16g, and the yield was 62.4 %.

[0027] Elemental Analysis: C 21 h 20 N 4 o 2 (bbb·CH 3 CH 2 OH·H 2 O), the theoretically calculated value is C, 71.11%; H, 6.23%; N, 14.42%, the experimental value is C, 71.48%; H, 6.I1%; N, 14.33%; Infrared spectrum: IR (KBr, cm -1 ): 3406, 3058, 1627, 1534, 1437, 1379, 1310, 1271, 1155, 839, 799, 724; Proton NMR spectrum: 1 HNMR: (300MHz, CDCl 3 ):1.26(m, ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a benzimidazole zinc complex and a preparation method thereof. A chemical name of the benzimidazole zinc complex is dichloro-2-(2-(1H-benzimidazole-2-)benzyl)-1H-benzimidazole zinc complex. The preparation method includes following steps: mixing 2-(carboxymethyl)benzoic acid with o-phenylenediamine, placing the mixture in phosphoric acid, performing a heating process at 180 DEG C for 3 hours to obtain a purple-green reactant, cooling the reactant to room temperature, adding distilled water, performing a neutralization reaction to obtain a yellow-green solid, performing a washing process through distilled water for three times, carrying out a filtering process, carrying out a recrystallization process through alcohol to obtain a yellow-green solid 2-(2-(1H-benzimidazole-2-)benzyl)-1H-benzimidazole, namely a ligand, dissolving ZnCl2 and the ligand 2-(2-(1H-benzimidazole-2-)benzyl)-1H-benzimidazole in a proper amount of a DMF solvent to obtain a mixture, stirring the mixture uniformly at room temperature, performing a volatilization process for seven days to obtain a slight yellow-green block-shaped complex monocrystal. The complex employs biological non-toxic element zinc as a metal ion, can be used for preparing antitumor drugs, can inhibit generation of esophagus cancer cells, and is free from remaining in human body and causing poisoning in human body due to metal accumulation. The complex is simple in the preparation method, is high in yield, is low in cost and is suitable for an industrial production.

Description

technical field [0001] The invention relates to a complex and a preparation method thereof, in particular to a benzimidazole zinc complex with antitumor effect and a preparation method thereof, belonging to the technical field of metal complex antitumor drugs. Background technique [0002] Esophageal cancer is a malignant tumor occurring in the esophageal epithelium, which seriously threatens human health. Esophageal cancer is the fourth most deadly tumor in my country, accounting for 5.5% of the death toll (Chen Wanqing, Zhang Siwei, Zheng Rongshou et al. China Oncology, 2011, 03: 162-9). Since most patients in the early stage have no obvious symptoms, more than 95% of the first clinically diagnosed esophageal cancer patients are in the middle and advanced stages. At present, chemotherapy is the main and most effective method for the treatment of advanced esophageal cancer. [0003] At the end of the 20th century, research on inorganic drugs has become a worldwide hotspot...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07F3/06A61P35/00A61P3/02
Inventor 刘生桂李国璧苏文义
Owner ZHANJIANG NORMAL UNIV
Features
  • Generate Ideas
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com