A kind of preparation method of phosphoric sugar alcohol tetrahydrothiazole-4-carboxylic acid compound

A technology of carboxylic acid compound and tetrahydrothiazole, which is applied in the field of preparation of phosphate sugar alcohol tetrahydrothiazole-4-carboxylic acid compound to achieve the effect of supplementing the loss of metal ions

Active Publication Date: 2017-02-15
魏景芬
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can be seen that phosphoribose plays a key role in the regeneration and recovery of ATP, but the phosphorylation of ribose from glucose through the pentose phosphorylation pathway is limited by glucose-6-phosphate dehydrogenase (G-6-PD)

Method used

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  • A kind of preparation method of phosphoric sugar alcohol tetrahydrothiazole-4-carboxylic acid compound
  • A kind of preparation method of phosphoric sugar alcohol tetrahydrothiazole-4-carboxylic acid compound
  • A kind of preparation method of phosphoric sugar alcohol tetrahydrothiazole-4-carboxylic acid compound

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preparation example Construction

[0051] The preparation method of the first phosphate sugar alcohol tetrahydrothiazole-4-carboxylic acid compound comprises the following steps:

[0052] A kind of preparation method of phosphoric sugar alcohol tetrahydrothiazole-4-carboxylic acid compound, comprises the following steps:

[0053] 1) Selecting one of cysteine ​​or phosphate sugar alcohol compounds as a raw material, dissolving the above compounds with a polar solvent;

[0054] 2) Choose the one with R 2 Phosphate sugar alcohol compound solution with functional groups or with R 1 Cysteine ​​solution of functional groups, stirred at room temperature for 12-24 hours; here R 2 Phosphate sugar alcohol compound solution with functional groups or with R 1 The selection of the cysteine ​​solution of functional group is based on: when selecting cysteine ​​as raw material in step 1), what is selected in step 2) is to have R 2 The phosphate sugar alcohol compound solution of functional group; When step 1) selects phosp...

Embodiment 1

[0064] Weigh 27.4 kg of D-ribose-5-phosphate disodium salt, stir with 50 kg of deionized water until completely dissolved, add 12.2 kg of calcium chloride solid in 18 kg of water, and stir at room temperature for more than 12 hours. Add 150 kg of ethanol, stir for 2 hours, filter, collect the solid, wash with ethanol, and obtain 25.5 kg of white solid product as D-ribose-5-phosphate calcium salt. In a nitrogen-protected reaction vessel, weigh 25.5 kg of D-ribose-5-phosphate calcium salt, add 100 kg of deionized water and stir until completely dissolved, then add 15 kg of L-cysteine ​​hydrochloride, and stir until completely Dissolve, add 7.52 kg of pyridine, and stir at room temperature for more than 24 hours. Add 300 kg of ethanol, lower the temperature to less than 5 degrees Celsius, stir for 2 hours, filter and wash with cold ethanol to obtain 30.36 kg of white solid product. The yield was 86%, and the product was confirmed by NMR, IR and mass spectrometry.

Embodiment 2

[0066] Weigh 27.4 kg of D-ribose-5-phosphate disodium salt, stir with 50 kg of deionized water until completely dissolved, add 13.94 kg of ferrous chloride dissolved in 25 kg of water, and stir at room temperature for more than 12 hours. Add 150 kg of ethanol, stir for 2 hours, filter, collect the solid, wash with ethanol, and obtain 26.9 kg of white solid product which is ferrous D-ribose-5-phosphate. In a nitrogen-protected reaction vessel, weigh 26.9 kilograms of D-ribose-5-ferrous phosphate, add 100 kilograms of deionized water and stir until completely dissolved, then add 15 kilograms of D-cysteine ​​hydrochloride, and stir until After completely dissolving, 7.52 kg of pyridine was added and stirred at room temperature for more than 24 hours. Add 300 kg of ethanol, lower the temperature to less than 5 degrees Celsius, stir for 2 hours, filter and wash with cold ethanol to obtain 29.78 kg of white solid product. The yield was 81%, and the product was confirmed by NMR, IR ...

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Abstract

The invention relates to a preparation method of a sugar alcohol phosphate thiazolidine-4-carboxy compound with the structural formula as the specification. The compound is formed by integrating three groups and can release cysteine and ribose phosphate after being absorbed in vivo. Cysteine can be used for increasing the concentration of glutathione (GSH) in cells, improving the oxidation resistance of the cells and improving the inflammation diminishing and detoxifying capabilities of a human body from inside to outside. Ribose phosphate can be used for replenishing the energy loss caused by wounds or strenuous exercise while rapidly and effectively improving the ATP (Adenosine Triphosphate) level in tissues. Bodybuilding and brain-strengthening effects can be synchronously realized through the combination of carboxylate and phosphate groups and different trace elements.

Description

technical field [0001] The invention belongs to the field of phosphoric sugar alcohol tetrahydrothiazole-4-carboxylic acid compounds, and specifically refers to a preparation method of phosphoric sugar alcohol tetrahydrothiazole-4-carboxylic acid compounds. Background technique [0002] Glutathione (GSH) is present in nearly every cell of the body. It can help the body maintain normal immune system functions, and has antioxidant and integrated detoxification effects. The sulfhydryl group on cysteine ​​is its active group, which is easy to interact with certain drugs (such as paracetamol), toxins (such as free radicals) , iodoacetic acid, mustard gas, heavy metals such as lead, mercury, arsenic), etc., so that harmful poisons in the body are converted into harmless substances, excreted out of the body, and have a detoxification effect. Another main physiological role of glutathione is as an important antioxidant in the body. It can remove free radicals in the human body, cle...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07F9/6539
Inventor 魏景芬魏景强姜志良
Owner 魏景芬
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