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A kind of personalized bone repair material and its preparation method

A bone repair and organic material technology, applied in the field of bioengineering, can solve problems such as difficult to repair bone tissue, shortage of donors, shortage of bone tissue, etc., and achieve the effect of reducing allogeneic rejection

Active Publication Date: 2016-08-31
SHENZHEN POLYTECHNIC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

With the development of medical science, artificial bone transplantation technology has been widely used clinically, but there are still some problems in artificial bone transplantation, the most serious of which is the shortage of bone tissue and insufficient donors. Remains difficult to repair damaged bone tissue or restore long-term function

Method used

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  • A kind of personalized bone repair material and its preparation method
  • A kind of personalized bone repair material and its preparation method
  • A kind of personalized bone repair material and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Embodiment 1. Personalized bone tissue material ratio

[0051] Weigh 1g of hydroxyapatite or α-tricalcium phosphate or β-tricalcium phosphate or tetracalcium phosphate and place it in a container with one end closed, add 2ml of acetone and seal one end, shake to make the acetone infiltrate the hydroxyapatite.

[0052] Weigh 0.2g of PLGA (poly(D,L-lactic acid-co-glycolic acid), PLA:PGA=75:25) or PGA (polyglycolide) or PLA (poly(L- Lactic acid)), placed in a closed container at one end, after adding acetone with a volume of 0.2ml, the other end was closed to completely dissolve PLGA.

[0053] Completely add the dissolved organic material into the inorganic material, oscillate and stir evenly, and seal it.

[0054] Get a portion of lyophilized lipid microsphere powder, which contains 100ng / part of nerve cell growth factor (NGF), 120ng / part of recombinant human interferon (IFN-β), bone protein (BMP- 2) 100ng / part. Add it to the prepared material liquid above, and mix qui...

Embodiment 2

[0055] Example 2 Preparation of Personalized Bone Tissue Material

[0056] Use non-invasive computed tomography (CT) and magnetic resonance imaging (MRI) to collect individualized three-dimensional data of bone injuries. The collected tomographic image slices are processed by mimic or 3dMed software, converted into three-dimensional space vector data, and then passed through three-dimensional The design software Autodesk3ds Max is converted into a 3D printing model, and compiled into a 3D printer recognition file format such as an STL file.

[0057] Set the printing parameters of the three-dimensional material bracket. The materials between layers are vertically cross-stacked. Each layer is placed in parallel. The gap between each strip is 1mm, and the step height in the Z-axis direction is 0.1mm. X The moving speed in the axial and Y-axis directions is 2mm / s, the hole diameter of the outlet is controlled between 0.5mm-0.1mm, and the pressure of the outlet is controlled betwee...

Embodiment 3

[0064] Example 3 Personalized bone tissue material (addition of cytokine IFN-β) induces chondrogenic differentiation of hMSC cells

[0065] Use non-invasive computed tomography (CT) and magnetic resonance imaging (MRI) to collect individualized three-dimensional data of bone injuries. The collected tomographic image slices are processed by mimic or 3dMed software, converted into three-dimensional space vector data, and then passed through three-dimensional The design software Autodesk3ds Max is converted into a 3D printing model, and compiled into a 3D printer recognition file format such as an STL file.

[0066] Set the printing parameters of the three-dimensional material bracket. The materials between layers are vertically cross-stacked. Each layer is placed in parallel. The gap between each strip is 1mm, and the step height in the Z-axis direction is 0.1mm. X The moving speed in the axial and Y-axis directions is 2mm / s, the hole diameter of the outlet is controlled between...

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Abstract

The invention relates to a personalized bone repair material and a preparation method thereof. The bone repair material includes an organic material and an inorganic material with a mass ratio of 0.1-0.6:1, and a protein-encapsulated lipid microsphere powder. The bone repair material can be used for personalized bone repair, it is biocompatible and degradable, and has the characteristics of safety, three-dimensional network structure and balanced degradation required by biological bone materials.

Description

technical field [0001] The invention relates to the field of bioengineering, in particular to a bioremediation material. [0002] The invention also relates to a preparation method of the bioremediation material. Background technique [0003] Bone tissue damage is a major problem facing human health. With the development of medical science, artificial bone transplantation technology has been widely used clinically, but there are still some problems in artificial bone transplantation, the most serious of which is the shortage of bone tissue and insufficient donors. It is still difficult to repair damaged bone tissue or restore its function in the long term. Biomanufacturing engineering is an important potential alternative therapeutic measure that promises to finally address this issue. When individual bone tissue is damaged or missing, biomanufacturing technology adopts the method of implanting organ substitutes for personalized treatment. This method can already have the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N5/07A61L27/18A61L27/12A61L27/54A61L27/50A61L27/58A61L27/22
Inventor 张丽君张英张登央王飞王妍
Owner SHENZHEN POLYTECHNIC
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