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Pharmaceutical composition for treating post-chemotherapeutic osteoporosis and use thereof

An osteoporosis and composition technology, applied in drug combination, bone diseases, etc., can solve the problems of increasing bone density and bone weight coefficient, poor symptom control, increasing blood phosphorus and calcium, etc. Serum calcium, definite therapeutic effect, serum phosphorus, and the effect of reducing serum alkaline phosphatase action

Inactive Publication Date: 2015-06-17
王鹏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] In order to overcome the technical deficiencies in the prior art that the symptoms of osteoporosis after chemotherapy for malignant tumors are not well controlled, the present invention provides a pharmaceutical composition for treating osteoporosis after chemotherapy for malignant tumors, which contains alendronate Pomalidomide and pomalidomide are the active ingredients of the medicine. When the medicine composition is used for the treatment of osteoporosis after chemotherapy for malignant tumors, the symptoms are well controlled, and it can improve bone density and bone weight coefficient as well as blood phosphate levels. It has a significant synergistic effect in terms of calcium content, and is suitable for the treatment of osteoporosis caused by clinical tumor chemotherapy

Method used

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  • Pharmaceutical composition for treating post-chemotherapeutic osteoporosis and use thereof
  • Pharmaceutical composition for treating post-chemotherapeutic osteoporosis and use thereof
  • Pharmaceutical composition for treating post-chemotherapeutic osteoporosis and use thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0020] The preparation of embodiment 1 alendronic acid pomalidomide compound tablet

[0021]

[0022] Preparation process: first put alendronic acid and cyclodextrin into a mortar, grind and mix evenly, then add carboxymethyl starch sodium, compressible starch and mix evenly, finally add pomalidomide and mix evenly, use 5% PVP The anhydrous ethanol solution is used as a binder to granulate, dried at 40°C, granulated, added with magnesium stearate, mixed evenly, and compressed into tablets.

Embodiment 2

[0023] The preparation of embodiment 2 alendronic acid pomalidomide compound tablet

[0024]

[0025] Preparation process: first put alendronic acid and cyclodextrin into a mortar, grind and mix evenly, then add carboxymethyl starch sodium, compressible starch and mix evenly, finally add pomalidomide and mix evenly, use 5% PVP The anhydrous ethanol solution is used as a binder to granulate, dried at 40°C, granulated, added with magnesium stearate, mixed evenly, and compressed into tablets.

Embodiment 3

[0026] The preparation of embodiment 3 alendronic acid pomalidomide compound tablet

[0027]

[0028] Preparation process: first put alendronic acid and β-cyclodextrin into a mortar and grind and mix evenly, then add sodium carboxymethyl starch, microcrystalline cellulose, and micropowder silica gel to mix evenly, and finally add pomalidomide and mix evenly , and the powder is directly compressed into tablets.

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Abstract

The invention relates to a pharmaceutical composition for treating post-malignant tumor-chemotherapeutic osteoporosis and use thereof and belongs to the field of medicines. In order to overcome the technical defect that the medicine for treating post-malignant tumor-chemotherapeutic osteoporosis in the prior art is poor to control symptoms, the invention provides a pharmaceutical composition containing alendronic acid and pomalidomide. The pharmaceutical composition used for treating post-malignant tumor-chemotherapeutic osteoporosis is good to control symptoms and has a remarkable effect in increasing bone mineral density and bone weight coefficient as well as increasing content of serum inorganic phosphorus and blood calcium, so that the pharmaceutical composition is suitable for clinically treating tumor chemotherapy induced osteoporosis.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating osteoporosis after chemotherapy and its use, in particular to a pharmaceutical composition comprising alendronic acid and pomalidomide and its use for treating malignant tumors after chemotherapy. The medicine application of osteoporosis belongs to the field of medicine. Background technique [0002] Malignant tumor, often called cancer, is a common and frequently-occurring disease that seriously threatens human health. Currently, the three major methods for treating malignant tumors include chemotherapy (abbreviated as chemotherapy), surgery and radiotherapy. The application of traditional cytotoxic antineoplastic drugs or anticancer drugs to chemotherapy still occupies an extremely important position in the comprehensive treatment of tumors. Some malignant tumors such as choriocarcinoma and malignant lymphoma may be cured by chemotherapy. However, the treatment of solid tumors, whic...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/663A61P19/10A61K31/4439
Inventor 王鹏
Owner 王鹏
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