A kind of method for synthesizing clean production of metronidazole crude drug

A clean production, metronidazole technology, applied in neutralization water/sewage treatment, organic chemistry and other directions, can solve the problems of high cost of environmental protection, environmental pollution, and high pressure of environmental protection, to increase environmental protection processing capacity and environmental pollution. The effect of reducing the degree, improving the social and economic benefits

Active Publication Date: 2016-09-28
DONGGANG HONGDA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The synthetic process routes are basically the same, and there is a certain degree of environmental pollution, the pressure on environmental protection is high, and the cost of environmental protection is relatively high.
Environmental pollution is the core problem restricting the production of metronidazole raw materials

Method used

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  • A kind of method for synthesizing clean production of metronidazole crude drug
  • A kind of method for synthesizing clean production of metronidazole crude drug
  • A kind of method for synthesizing clean production of metronidazole crude drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 2

[0063] Embodiment two replaces 30% sodium hydroxide solution with the neutralization mother liquor for the second time

[0064] In formic acid 400Kg, sulfuric acid 313Kg mixed solvent, nitro 565Kg and oxirane 400Kg carry out hydroxylation reaction, wherein oxirane and sulfuric acid are added in stages;

[0065] Specifically: ①Preparation of mixed acid: pump 400Kg of formic acid and 249Kg of sulfuric acid into the metering tank respectively, put the formic acid into the mixed acid tank, drop the sulfuric acid into the mixed acid tank below 25°C, stir evenly and set aside.

[0066] ②Hydroxylation reaction: 565Kg of 2-methyl-5-nitroimidazole (abbreviated as nitro, hereinafter the same) (self-made or commercially available 2-methyl-5-nitroimidazole is 565Kg of raw nitrate; Or self-made or purchased commercially available 2-methyl-5-nitroimidazole is 350Kg of raw nitrate, and 2-methyl-5-nitroimidazole recovered in the first neutralization process is 215Kg of back nitrate) put into ...

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Abstract

The invention relates to a clean production method for synthesizing metronidazole, and belongs to the field of the organic synthesis of drugs. The method comprises the following steps: 1, utilizing a neutralizing second mother liquor (with the pH value of 10.5-11.0) in a metronidazole synthesis process to substitute a 30% sodium hydroxide solution to be used in a neutralization reaction of a metronidazole hydroxylation liquid; and 2, carrying out concentrated recovery on the above finally obtained metronidazole production mother liquor before emission, neutralizing the mother liquor by sulfuric acid until the pH value is 5.0-6.0, allowing the neutralized solution to stand for above 6h, centrifuging to obtain a nitro substance, and sending the recovered mother liquor to a sewage treatment station. About 200kg of the 30% sodium hydroxide solution is saved each batch, the emission of the neutralizing second mother liquor (with the pH value of 10.5-11.0) is reduced, cycle production is formed, the environmental protection throughput is reduced, and the production cost is reduced. The wet product of the recovered nitro substance in each batch is about 18kg, so the production cost is reduced, and the environmental protection throughout is reduced.

Description

technical field [0001] The invention relates to the production of metronidazole, in particular to a clean production method for synthesizing a metronidazole crude drug. Background technique [0002] Metronidazole, alias: metronidazole. Belongs to national essential medicines. It is white or light yellow crystal or crystalline powder. It has broad-spectrum anti-anaerobic and antiprotozoal effects, and is mainly used to treat systemic or local infections caused by anaerobic bacteria, as well as amoebiasis and trichomonal vaginitis. [0003] At present, there are 7 pharmaceutical factories in my country to synthesize metronidazole raw materials, with a total annual output of about 7,000 tons, 50% of which are sold domestically and 50% are exported. The synthetic process routes are basically the same, and there is a certain degree of environmental pollution, and the pressure on environmental protection is high, and the cost of environmental protection is relatively high. Env...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D233/94C02F1/66
CPCC07D233/94
Inventor 程绍春宫润平于波
Owner DONGGANG HONGDA PHARMA
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