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Cardiovascular stent with Ag-TiO2 coating on surface and preparation method of cardiovascular stent

A cardiovascular and coating technology, applied in the field of cardiovascular stents with Ag-TiO2 coating on the surface and its preparation, can solve problems such as easy fracture or collapse, poor corrosion resistance of magnesium and magnesium alloys, loss of support, etc. , to achieve the effect of prolonging the service life, high use value and good biocompatibility

Active Publication Date: 2014-12-10
DONGGUAN REVOLUTION PROD DESIGN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the corrosion resistance of magnesium and magnesium alloys is poor, and the standard potential of pure magnesium is -2.37V, especially in the human physiological environment containing Cl- ions; the corrosion degradation rate of conventional magnesium and magnesium alloys in simulated body fluids Can reach 0.05-6mm / year
In addition, the magnesium alloy stent implanted in the cardiovascular system is easily broken or collapsed by the impact of blood flow; thus losing the supporting effect before the vascular shaping, and even causing death, which largely limits the application of the magnesium alloy stent in the cardiovascular system. Further applications in scaffolds

Method used

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  • Cardiovascular stent with Ag-TiO2 coating on surface and preparation method of cardiovascular stent

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Comparison scheme
Effect test

Embodiment 1

[0024] A surface with Ag-TiO 2 A coated cardiovascular stent, including a base layer 1 of the cardiovascular stent and an Ag coating 2 covered thereon, the Ag-TiO 2 The coating 2 includes an oxide film layer 21 , and the oxide film layer 21 contains nano-silver and / or silver oxide particles 22 .

[0025] The base layer 1 of the cardiovascular stent is one of magnesium-titanium alloy, magnesium-titanium-aluminum alloy, magnesium-aluminum-chromium alloy, magnesium-aluminum-chromium-nickel alloy, and magnesium-aluminum-cobalt-chromium alloy.

[0026] The main component of the oxide film layer 21 is TiO 2 , is the uneven film layer. Uniformly cover the base layer 1 of the cardiovascular stent with a thickness of 1-100um, preferably 10-100um, most preferably 20-40um.

[0027] The nano-silver and / or silver oxide particles 22 are unevenly deposited or embedded in the oxide film layer 21 , and the concentration thereof decreases as the depth of the oxide film layer 21 increases.

Embodiment 2

[0029] The preparation method of the above-mentioned cardiovascular stent comprises the following steps:

[0030] 1) prepare colloidal dispersion system, described colloidal dispersion system comprises pure water with zero electrical conductivity, disperse particle, electrolyte and additive; Wherein, described disperse particle concentration is 50mg / L, is nano-silver particle, and particle size is 10- 30nm; the concentration of the additive is 10mg / L, which is magnesium oxide; the formula of the electrolyte is Na 2 SiO 3 115g / L, NaOH 20g / L, organic amine 15g / L, peroxide 5g / L;

[0031] 2) Put the colloid dispersion system into an electrolytic cell, dip the cardiovascular stent into the colloid dispersion system, then connect the cardiovascular stent to the positive pole of the power supply, set the negative pole of the power supply in the electrolytic cell, The negative pole of the power supply is cup-shaped and surrounds the positive pole of the power supply, and generates ...

Embodiment 3

[0033] The preparation method of the above-mentioned cardiovascular stent comprises the following steps:

[0034] 1) Prepare a colloidal dispersion system, which includes ion-exchanged water with low conductivity, dispersed particles, electrolytes and additives; wherein, the dispersed particle concentration is 100mg / L, which is silver oxide particles and / or nano silver Particles, particle size is 10nm; The concentration of the additive is 1mg / L, selected from magnesium oxide; The formula of the electrolyte is Na 2 SiO 310g / L, NaOH20g / L, organic amine 20g / L, peroxide 2g / L;

[0035] 2) Put the colloidal dispersion system into the electrolytic cell, dip the cardiovascular stent into the colloidal dispersion system, then connect the cardiovascular stent to the positive pole of the power supply, set the negative pole of the power supply in the electrolytic cell, and the The negative pole of the power supply is cup-shaped and surrounds the positive pole of the power supply, and an...

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Abstract

The invention provides a cardiovascular stent with an Ag-TiO2 coating on the surface. An Ag coating covers a base layer of the cardiovascular stent; the base layer of the cardiovascular stent refers to a magnesium-titanium alloy, a magnesium-titanium-aluminum alloy, a magnesium-titanium-chromium alloy, a magnesium-titanium-chromium-nickel alloy or a magnesium-titanium-cobalt-chromium alloy; the Ag-TiO2 coating comprises an oxide film layer; and the oxide film layer contains nano-silver and / or silver oxide particles. According to the Ag-TiO2 coating, the cardiovascular stent has high biocompatibility, antibacterial property and extremely high application value, and the service life of the cardiovascular stent in a human body is prolonged.

Description

technical field [0001] The invention relates to the technical field of cardiovascular stents, in particular to a surface with Ag-TiO 2 Coated cardiovascular stent and method for its preparation. Background technique [0002] Silver ions are known to strongly inhibit the growth of bacteria and other microorganisms. Silver ions destroy vital cellular components of microorganisms, rendering their disease-causing functions no longer possible. Silver exhibits broad-spectrum antimicrobial activity, even against antibiotin-resistant strains. In addition, silver targets multiple sites within the bacterial cell, thereby reducing the likelihood that the bacteria will develop any type of resistance. With the increasing resistance of most pathogenic bacteria to commonly used antibiotics, silver has recently been rediscovered as an antibacterial active. In fact, silver has long been used for hygienic and medical purposes due to its disinfecting properties. For example, silver compou...

Claims

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Application Information

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IPC IPC(8): A61L31/08A61L31/16C25D11/02C25D15/00A61L31/02
Inventor 李扬德
Owner DONGGUAN REVOLUTION PROD DESIGN
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