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Fermentation medium used in neomycin production adopting fermentation method

A fermentation medium and neomycin technology, applied in the direction of fermentation, microorganisms, and methods based on microorganisms, can solve the problems of low fermentation units, low output, and high production costs, and achieve the effect of improving economic benefits and increasing fermentation units

Inactive Publication Date: 2014-12-10
HEBEI SHENGXUE DACHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the main production method of neomycin is biological fermentation, which is produced by only a few manufacturers in China, mainly due to the low output and high production cost. The organic carbon source is corn starch, and the fermentation unit is relatively low, such as: Neomycin fermentation process research II. Streptomyces fradlae 61-7-12 strain fermentation, the highest fermentation unit is only 2200U / mL

Method used

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  • Fermentation medium used in neomycin production adopting fermentation method
  • Fermentation medium used in neomycin production adopting fermentation method
  • Fermentation medium used in neomycin production adopting fermentation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Weigh 90g of wheat starch, 40g of soybean meal powder, 8g of ammonium sulfate, 0.1g of disodium hydrogen phosphate, 25g of calcium carbonate, 1g of amylase, dilute the volume of drinking water to 1L, and insert the seeds of neomycin-producing bacteria Streptomyces freundii. The inoculum was 15%, the temperature was 35°C, and the bottle was cultured for 10 days, and the fermentation unit of neomycin was 33310 U / mL

Embodiment 2-8

[0027] The composition of the fermentation medium is shown in Table 1, and the fermentation method is the same as in Example 1.

[0028] Table 1

[0029]

[0030]

Embodiment 9-12

[0032] The composition of the fermentation medium is shown in Table 2, and the fermentation method is the same as in Example 1.

[0033] Table 2

[0034]

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Abstract

The invention discloses a fermentation medium used in the neomycin production adopting a fermentation method. The fermentation medium comprises an organic carbon source, an organic nitrogen source, inorganic salt and amylase, wherein the concentration of the organic carbon source is 60-110 g / L. After neomycin is produced by using the fermentation medium, the fermentation unit of the obtained neomycin can reach more than 33,310 U / mL, so that the profits of neomycin production enterprises can be greatly increased and the fermentation medium has a broad application prospect.

Description

technical field [0001] The invention belongs to the technical field of microbial fermentation, and in particular relates to a fermentation medium used for producing neomycin by a fermentation method. Background technique [0002] Neomycin, produced by Streptamyces fradiae, is an aminoglycoside broad-spectrum antibiotic that has a good effect on Gram-negative bacteria, positive bacteria and Mycobacterium tuberculosis. Neomycin is sensitive to Staphylococcus aureus, Bacillus anthracis, Bacillus diphtheria, Bacillus aerogenes, Proteus and Shigella, and is most sensitive to Escherichia coli. It is generally used orally for the treatment of diarrhea clinically, and has a better effect on infantile diarrhea caused by Escherichia coli , It can also be used for abdominal and preoperative medication. Topical application of neomycin is also effective against skin and mucous membrane infections caused by sensitive bacteria, such as abscesses, furuncles, ulcers and burns. [0003] At ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12P19/52C12R1/46
Inventor 张宝荣袁昉王绘砖李敏
Owner HEBEI SHENGXUE DACHENG PHARMA
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