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Application of astilbin or homolog thereof in preparation of drugs for treating psoriasis

A technology of fucoside homologue and astilbin, which can be used in drug combinations, skin diseases, pharmaceutical formulations, etc., can solve problems such as affecting the quality of life of patients, small side effects, lack of curative effect, etc., and achieve the effect of great clinical application value.

Active Publication Date: 2014-12-17
GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Different from other diseases, although about 80% of patients only have itching symptoms, psoriasis patients feel severe psychological pressure, low self-esteem, loss, and even suicidal tendencies due to the unsightly appearance of skin lesions, which greatly affects the patient quality of life
Modern medicine believes that the cause of this disease lies in the dysfunction of the immune system, and its treatment generally uses (oral or external) immunosuppressants, as well as corticosteroids or coal tar and other drugs that can improve the symptoms of skin lesions, such as anthralin, calcipotriol, Tazarotene, subcutaneous injection of corticosteroids or oral administration of Diyin tablets, retinoids, antineoplastic drugs and other methods, although short-term relief of symptoms is acceptable, but long-term application has serious side effects, and clinical efficacy is still lacking , Therapeutic drugs with few side effects

Method used

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  • Application of astilbin or homolog thereof in preparation of drugs for treating psoriasis
  • Application of astilbin or homolog thereof in preparation of drugs for treating psoriasis
  • Application of astilbin or homolog thereof in preparation of drugs for treating psoriasis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Effect of astilbin on propranolol-induced psoriasis model:

[0018] 1. 18 healthy adult albino guinea pigs, 4-5 weeks old, initial body weight 250-300g, male, numbered, weighed and recorded. According to the random number table method, 3 guinea pigs were taken as the blank control group, and the remaining 15 guinea pigs were used as the model group.

[0019] 2. Apply 5% propranolol hydrochloride emulsion evenly to the skin of the backs of the ears of guinea pigs with a cotton swab, apply the cream matrix to the skin according to the above method, and apply the blank matrix to the blank control group. The dosage for all animals is 0.2ml / ear each time , apply evenly, so that the back of the ear is covered with a thin layer, 3 times a day, with an interval of 3 hours between each time. Observe the body weight change and state of the guinea pigs every day. After one week of modeling, it was observed that the guinea pigs basically showed redness, swelling and even skin les...

Embodiment 2

[0035] Powder:

[0036] Astilbin 5g

[0037] Lactose 150g

[0038] Tween-80 15g

[0039] Preparation:

[0040] The powder can be obtained by mixing astilbin with other combinations and freeze-drying.

[0041] Nanoemulsion:

[0042] Astilbin 10g

[0043] Lecithin 5g

[0044] Pluronic 10g

[0045] Tween-80 2g

[0046] Glycerin 25g

[0047] Preparation:

[0048] Weigh the prescribed amount of glycerin and Tween-80, stir and disperse in appropriate amount of distilled water. Another appropriate amount of lecithin and Pluronic F-68 was added to the aqueous phase solution under stirring. After the lecithin and Planckney F-68 are completely dispersed, add astilbin into the water phase and stir magnetically at the same time to dissolve completely. Ultrasonic 6min, that is astilbin colostrum. Add distilled water to the colostrum to a certain amount under stirring, and then sonicate for 6min. The astilbin nanoemulsion with obvious opalescence can be obtained by circulati...

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Abstract

The invention discloses an application of astilbin or a homolog thereof in preparation of drugs for treating psoriasis. Animal experiments prove that the astilbin or the homolog thereof has a significant curative effect on psoriasis, and can be used for preparing the drugs for treating psoriasis. The astilbin or the homolog thereof has no toxic or side effect, also has no obvious untoward effect even with long-term taking, and has relatively great clinical application value.

Description

technical field [0001] The present invention relates to the new application of astilbin and its homologues. Background technique [0002] Psoriasis, commonly known as psoriasis, is a common chronic, relapsing, and immune-related disease. The clinical manifestations are based on infiltrating erythema, covered with multiple layers of silvery white phosphorous scales. Different from other diseases, although about 80% of patients only have itching symptoms, psoriasis patients feel severe psychological pressure, low self-esteem, loss, and even suicidal tendencies due to the unsightly appearance of skin lesions, which greatly affects the patient's quality of life. Modern medicine believes that the cause of this disease lies in the dysfunction of the immune system, and its treatment generally uses (oral or external) immunosuppressants, as well as corticosteroids or coal tar and other drugs that can improve the symptoms of skin lesions, such as anthralin, calcipotriol, Tazarotene...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P17/06
Inventor 卢传坚赵瑞芝肖志偲余靖宏冯丽敏陈振兴韩凌
Owner GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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