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Porous elastic polyvinyl alcohol/bacterial nanocellulose composite hydrogel tube and its preparation method and application

A nanocellulose and composite hydrogel technology, which is used in medical science, prosthesis, surgery, etc., can solve the problems of restricting the application of medical materials and the lack of elasticity of tubular materials, and achieves the advantages of adhesion and proliferation, low cost, and high efficiency. Beneficial for cell growth

Active Publication Date: 2017-03-29
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this tubular material made of nanocellulose has no elasticity, which limits its application as a medical material.

Method used

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  • Porous elastic polyvinyl alcohol/bacterial nanocellulose composite hydrogel tube and its preparation method and application
  • Porous elastic polyvinyl alcohol/bacterial nanocellulose composite hydrogel tube and its preparation method and application
  • Porous elastic polyvinyl alcohol/bacterial nanocellulose composite hydrogel tube and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] (1) Bacterial nanocellulose hydrogel tube pretreatment

[0038] Fix a bacterial nanocellulose hydrogel tube with an inner diameter of 3mm, an outer diameter of 5mm, and a length of 50mm to the outer wall of a glass tube with an inner diameter of 2mm and an outer diameter of 3mm, soak it in a solution with a NaOH concentration of 1% at 80°C for 4h, and then use it repeatedly Wash with ultrapure water until the endotoxin content is below 0.25 EU / g.

[0039] (2) Preparation of polyvinyl alcohol solution

[0040] Weigh 10g of polyvinyl alcohol (Mw=1750±50) into a blue-capped bottle filled with 70g of ultrapure water, tighten the cap and place in a shaking water bath at 95°C until completely dissolved, then add 20g of absolute ethanol, and tighten the bottle Cover and continue shaking in a water bath until a uniform solution is formed, take it out and let it cool down to room temperature for later use.

[0041] (3) Bacterial nanocellulose hydrogel tube combined with polyvi...

Embodiment 2

[0046] (1) Bacterial nanocellulose hydrogel tube pretreatment

[0047] Fix a bacterial nanocellulose hydrogel tube with an inner diameter of 6mm, an outer diameter of 8mm, and a length of 50mm to the outer wall of a glass tube with an inner diameter of 5mm and an outer diameter of 6mm, soak it in a 1% NaOH solution at 80°C for 4h, and then repeatedly wash it with a supernatant. Wash with pure water until the endotoxin content is below 0.25 EU / g.

[0048] (2) Preparation of polyvinyl alcohol solution

[0049] Weigh 10g of polyvinyl alcohol (Mw=1750±50) and 10g of NaCl into a blue cap bottle filled with 60g of ultrapure water, tighten the cap and place in a shaking water bath at 95°C until completely dissolved, then add 20g of absolute ethanol, Tighten the bottle cap and continue shaking in the water bath until a uniform solution is formed, take it out and let it cool down to room temperature for later use.

[0050] (3) Bacterial nanocellulose hydrogel tube combined with polyv...

Embodiment 3

[0055] (1) Bacterial nanocellulose hydrogel tube pretreatment

[0056] Fix a bacterial nanocellulose hydrogel tube with an inner diameter of 6 mm, an outer diameter of 8 mm, and a length of 50 mm on the outer wall of the glass tube, soak it in 1% NaOH solution at 80°C for 4 hours, and then wash it repeatedly with ultrapure water until the endotoxin content is reached. Below 0.25EU / g. (2) Preparation of polyvinyl alcohol solution

[0057] Weigh 15g of polyvinyl alcohol (1750±50) into a blue cap bottle filled with 65g of ultrapure water, tighten the cap and place in a 95°C shaking water bath until completely dissolved, then add 20g of absolute ethanol, tighten the cap to continue Shake in a water bath until a uniform solution is formed, take it out and let it cool down to room temperature for later use.

[0058] (3) Preparation of polyvinyl alcohol hydrogel tubes

[0059] Fill the inner cavity of a glass tube with an outer diameter of 6 mm and a wall thickness of 1 mm with ab...

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Abstract

The invention relates to a porous elastic polyvinyl alcohol / bacterial nano-cellulose composite hydrogel tube, as well as a preparation method and application of the composite hydrogel tube. The composite hydrogel tube comprises a surface layer and a lining layer, wherein the surface layer has a smooth surface, and the lining layer is of a nano-fiber network structure. The preparation method comprises the following steps: pretreating the bacterial nano-cellulose composite hydrogel tube; preparing a polyvinyl alcohol solution; freezing at minus 80 DEG C for molding; unfreezing by ethanol at minus 20 DEG C; and soaking in ultrapure water at room temperature to replace the ethanol. The porous elastic polyvinyl alcohol / bacterial nano-cellulose composite hydrogel tube is controllable in mechanical performance and can meet the requirements of multiple tissue repairing stents, the nano-fiber network structure of the composite hydrogel tube is advantageous to cell adhesion and proliferation, and the mutually communicated porous structure of the composite hydrogel structure is advantageous to nutrition transmission and cell ingrowth; and the porous elastic polyvinyl alcohol / bacterial nano-cellulose composite hydrogel tube is simple in preparation process and low in cost, and has a good application prospect in vascular repairing stents and nerve repairing stents.

Description

technical field [0001] The invention belongs to the field of composite hydrogel tubes, in particular to a porous elastic polyvinyl alcohol / bacterial nanocellulose composite hydrogel tube and its preparation method and application. Background technique [0002] The mismatch between stents made of synthetic materials and autologous tissues is an important factor leading to the failure of cardiovascular stent applications. The development of biomaterials with similar mechanical properties to the replaced tissue is an important consideration when preparing tissue engineering scaffolds and tissue substitutes. On the other hand, the currently clinically used artificial blood vessels made of polyester (PET) and expanded polytetrafluoroethylene (ePTFE) are used for small-diameter (<6mm) blood vessel replacement because the inner wall is rough and easy to form thrombus, which can cause severe as a result of. [0003] Bacterial nano-cellulose (BNC) is a kind of nano-cellulose pro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/12A61L31/14A61L27/44A61L27/56A61L27/52
Inventor 洪枫唐敬玉包露涵张青松洪思仪陈琳
Owner DONGHUA UNIV
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