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Application of caulis flavone A in preparation of anti-HIV drug

A technology of anti-AIDS and garcinia, which is applied in the field of medicine and can solve the problems such as the absence of garcinia

Inactive Publication Date: 2014-12-24
NANJING BIAOKE BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Through literature search, no garcinone A has been used in the preparation of anti-AIDS drugs in China

Method used

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  • Application of caulis flavone A in preparation of anti-HIV drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Preparation of Gambogene A

[0024] Take 500g of coarse fruit powder of Mangosteen lishii, put it in an extraction kettle, add methanol as an entrainer at a solid-to-liquid volume ratio of 5:2, and feed liquid CO under the conditions of pressure 22MPa and temperature 38°C 2 , CO 2 The flow rate is 4.5ml / g crude drug / min, extract for 120min, analyze at a pressure of 7MPa and a temperature of 32°C, collect the extract, add 15g of diatomaceous earth to stir for decolorization, filter to obtain a decolorization solution, and concentrate to a relative density of 1.12, above Alumina column (column pressure 6bar, column diameter-to-height ratio 1:8), elution and purification with petroleum ether-ethyl acetate 3:14, to obtain the crude product of garcinia ketone A; with a volume ratio of 19:38:45 methanol- Acetonitrile-water is the mobile phase, the crude product is dissolved in the mobile phase, injected into the preparative high-performance liquid chromatograph, the flow rat...

Embodiment 2

[0044] Tablets: 40 g of garcinone A, 135 g of starch, 25 g of chenodeoxycholate, granulated and compressed into 1000 tablets. Dosage: Adults take 1 tablet at a time, 2 times a day.

Embodiment 3

[0046] Capsules: 40g of garcinia ketone A, 135g of starch, 25g of chitosan, mixed well, and made into 1000 capsules. Dosage: Adults take 1 capsule at a time, 2 times a day.

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Abstract

The invention discloses application of caulis flavone A in preparation of an anti-HIV drug; the anti-HIV effect of caulis flavone A is observed through in-vitro cytotoxicity tests and in-vitro HIV inhibition tests; and the results show that caulis flavone A has a certain inhibiting effect on HIV-1 standard strains, clinical strains and pseudovirus and has the activity of inhibiting HIV-1 virus replication. Caulis flavone A is prepared into the anti-HIV drug together with pharmaceutically acceptable auxiliary materials; and the dosage form of the drug is one of injection, capsules, troches, granules, pills, mixture and oral liquid.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to the application of gammonone A in the preparation of anti-AIDS drugs. Background technique [0002] Gambogene A (Castanospermine) is an active ingredient isolated from the fruit of Garcinia livingstonei T.Anderson. Modern pharmacological studies have shown that garcinia ketone A has anti-HIV effects, and inhibits human lymphocytes from being infected by HIV in vitro, and its EC50 is 1-10 μg / mL. [0003] Garcinone A, the molecular formula is C 38 h 50 o 6 , the molecular weight is 602.81, and the structural formula is [0004] [0005] According to the literature search, no garcinone A has been used in the preparation of anti-AIDS drugs in China. Contents of the invention [0006] In order to meet the clinical needs, expand the variety of drugs, and better treat AIDS, garcinone A is used to prepare anti-AIDS drugs. [0007] Technical scheme of the present invention is as follows: ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/122A61P31/18
Inventor 张金芳杨存
Owner NANJING BIAOKE BIO TECH
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