A method and equipment for extracting medicinal active ingredients of Chinese medicinal materials

A technology of active ingredients and extraction methods, applied in the field of medicine, can solve the problems of long cycle (the extraction process takes 2-3 hours, the water content of medicinal residues is large, and it is difficult to detect on-line), so as to save the amount of solvent and the cost of separation. , Improve the extraction yield, the effect of easy operation

Active Publication Date: 2017-12-15
长春康彼达科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the existing extraction methods, the amount of solvent used is large (generally 12 to 20 times the amount of medicinal materials), the number of repetitions is large (usually 3 times), the cycle is long (the extraction process takes 2-3 hours), and energy consumption is high. It is not easy to realize online detection, and the quality is difficult to control randomly
The water content of medicinal dregs is high (70--80%), the investment in treatment is high, and the environment is polluted

Method used

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  • A method and equipment for extracting medicinal active ingredients of Chinese medicinal materials
  • A method and equipment for extracting medicinal active ingredients of Chinese medicinal materials
  • A method and equipment for extracting medicinal active ingredients of Chinese medicinal materials

Examples

Experimental program
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Effect test

Embodiment 1

[0022] Drum-type extraction machine for medicinal active ingredients of Chinese herbal medicines and the extraction process.

[0023] The medicinal active ingredient extraction machine of Chinese herbal medicines of the present embodiment comprises a casing 1-1 containing a solvent, a drum 1-2 installed in the casing by a central shaft and a bearing, and a mesh bag 1 for adorning Chinese medicine decoction pieces in the drum. -5, there is a movable cover 1-3 on the upper end of the box, a solvent adding interface 1-4 on the upper end of the box, a solvent outlet 1-5 on the lower end of the box and a connection with the separation and concentration macroporous adsorption resin or other downstream equipment Take the liquid collection interface 1-11. A bypass pipe 1-7 connected to the casing is provided outside the casing on the side wall of the casing relative to the circumferential surface of the drum, and sampling joints 1-8, 1-9, 1-10 required for line detection and analysis ...

Embodiment 2

[0026] Roller-type extraction machine for medicinal active ingredients of Chinese herbal medicines and the extraction process.

[0027] The extractor in the present embodiment comprises a casing 2-1 for containing the solvent, a roller 2-2 installed in the casing through a central shaft 2-5 and a bearing, and several evenly distributed net bag containing cages fixed on the circumference of the roller. 2-3, net bag 2-11 for Chinese medicine decoction pieces packed in the net bag containing cage; the upper part of the box body corresponds to the position of the movement circle track of the mesh bag containing cage, there is a mesh bag loading and unloading door 2-12, and the upper end of the box body has a solvent to add Interface 2-4, solvent discharge port 2-6 at the lower end of the box, temperature sensor and liquid level sensor in the box, roller drive motor fixed on the box outside, and control extraction temperature, liquid level sensor outside the box The control device ...

Embodiment 3

[0030] Use the drum-type Chinese herbal medicinal active ingredient extraction machine as described in Example 1 to extract. Take the extraction of licorice active ingredients with ethanol as an example. Mix ethanol and hay decoction pieces in a weight ratio of 3:1, and the ethanol temperature is 30°C. Start the roller motor, the peripheral speed of the roller is controlled at 20 m / min, run for 100 minutes, open the solvent discharge port, and discharge the ethanol (medicine liquid) containing the active ingredient. Increase the rotation speed of the drum to 800-1200 rpm, dealcoholize the drug dregs by centrifugation, collect the drug solution separated by centrifugation, and complete an extraction. Inject ethanol into the box again, repeat the aforementioned process, combine the medicinal liquids extracted twice, concentrate, and dry to obtain the extract.

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Abstract

The invention discloses an extraction method and device for active pharmaceutical ingredients of traditional Chinese medicinal materials. The extraction method comprises the steps as follows: traditional Chinese medicine decoction pieces are placed in a mesh bag, the mesh bag containing the traditional Chinese medicine decoction pieces moves in a solvent relative to the solvent, the weight ratio of the solvent to the traditional Chinese medicine decoction pieces is in a range of (3-8):1, the extraction temperature is between the room temperature and the boiling point, the movement speed of the mesh bag relative to the solvent is in a range of 20-60 m / min, and the extraction time is in a range of 20-200 min. The extraction device comprises a box for containing the solvent, a drum in the box, the mesh bag, a solvent adding port, a solvent drain port and a control device, wherein the mesh bag contains the traditional Chinese medicine decoction pieces and is placed in the drum, and the solvent adding port, the solvent drain port and the control device are arranged on the box. The extraction method and device have the benefits that the extraction time is substantially shortened, and the consumption of the solvent is reduced; soaking, extraction, solid-liquid separation, centrifugal drying of dregs are finished continuously in one time, the pollution caused by the dregs to the environment is eliminated, the drug preparation cycle is shortened, the production cost is reduced, quality monitoring on finished products is facilitated, and requirements of standard verification of new drug development and traditional Chinese medicinal production technologies are met.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the extraction of medicinal active ingredients of traditional Chinese medicines. Background technique [0002] In the past, the extraction of medicinal active ingredients of Chinese herbal medicines mostly used water decoction extraction, ethanol reflux extraction, cold soaking extraction and a few ultra-high pressure and ultra-high frequency extraction. In the existing extraction methods, the amount of solvent used is large (generally 12 to 20 times the amount of medicinal materials), the number of repetitions is large (usually 3 times), the cycle is long (the extraction process takes 2-3 hours), and energy consumption is high. It is not easy to realize online detection, and the quality is difficult to control randomly. The water content of medicinal dregs is high (70--80%), and the investment in treatment is high, which pollutes the environment. Contents of the invention ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/233A61K36/484B01D11/02
CPCB01D11/0273
Inventor 高陆王莲萍
Owner 长春康彼达科技有限公司
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