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Preparation method of modified carboxymethyl cellulose carrier with targeting effect

A technology of carboxymethyl cellulose and cellulose, applied in the field of polymer functional materials, can solve the problems of waste of resources, pollution of the environment, etc., and achieve the effects of no secondary pollution, high adsorption, and improved therapeutic effect

Active Publication Date: 2016-07-13
江苏派克斯特纤维素有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Cellulose is the most abundant natural organic renewable resource on the earth, but unfortunately a lot of cellulose has not been rationally utilized. The typical waste of resources is burning straw, which not only causes waste of resources, but also seriously pollutes the environment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] S1, cotton fiber is placed in the sodium hydroxide solution that mass concentration is 1%, bath ratio is 1:40, heats and boils 40min, adopts plate and frame filter press to press filter and then cotton fiber is placed in mass concentration and is 5% Sodium hydroxide solution, bath ratio 1:40, stand at 20-40°C for 60 minutes, take out, wash and dry to obtain alkaline cotton fiber;

[0018] S2, pulverize the alkaline cotton fiber obtained in step S1, add it to deionized water, the bath ratio is 1:20, adjust the pH value to 8, slowly add the etherification agent monochloroacetic acid (commercially available) dropwise while stirring, React at 40°C for 2 hours. After the reaction, adjust the pH value of the product to neutral with dilute hydrochloric acid, filter with suction and wash with absolute ethanol and deionized water accordingly, dry and grind to obtain carboxymethyl cotton fiber;

[0019] S3, magnetic inorganic particle iron is added in the No. 1 container that deh...

Embodiment 2

[0021] S1. Place the microcrystalline cellulose in a sodium hydroxide solution with a mass concentration of 3%, with a bath ratio of 1:80, heat and boil for 60 minutes, and then filter the cotton fiber with a mass concentration of 30 min using a plate and frame filter press. % sodium hydroxide solution, bath ratio 1:60, stand at 40°C for 60min, take out, wash and dry to obtain alkaline microcrystalline cellulose;

[0022] S2, pulverize the basic microcrystalline cellulose obtained in step S1, add it to absolute ethanol, the bath ratio is 1:50, adjust the pH value to 9, and slowly add the etherification agent monochloroacetic acid (marketed purchased), and reacted at 60°C for 4 hours. After the reaction, adjust the pH value of the product to neutral with dilute hydrochloric acid, filter with suction and wash with absolute ethanol and deionized water accordingly, dry and grind to obtain carboxymethyl Crystalline cellulose;

[0023] S3. Add ferric iron tetroxide, the magnetic in...

Embodiment 3

[0025] S1, the pulp is placed in a sodium hydroxide solution with a mass concentration of 5%, the bath ratio is 1:60, heated and boiled for 80min, and then the cotton fiber is placed in a 20% sodium hydroxide solution after being filtered by a plate and frame filter press. Sodium hydroxide solution, bath ratio 1:70, stand at 30°C for 120 minutes, take out, wash and dry to obtain alkaline pulp;

[0026] S2, crush the alkaline pulp obtained in step S1, add it to absolute ethanol, the bath ratio is 1:40, adjust the pH value to 7, and slowly add the etherification agent monochloroacetic acid (commercially available) dropwise while stirring , react at 60°C for 3 hours, after the reaction, adjust the pH value of the product to neutral with dilute hydrochloric acid, filter with suction and wash with absolute ethanol and deionized water accordingly, dry and grind to obtain carboxymethyl pulp;

[0027] S3. Add the magnetic inorganic particle nickel into the No. 1 container with acetone...

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PUM

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Abstract

The invention discloses a preparation method of a modified carboxymethyl cellulose carrier with targeting effect, which is beneficial in that: (1) natural cellulose is used as the object of modification, and the raw material is cheap and easy to obtain, and can be regenerated, Degradable, safe and environmentally friendly, no secondary pollution; (2) The process of the present invention is simple and easy to implement, and can prepare a carboxymethyl cellulose carrier with high-efficiency adsorption. Selective delivery to the diseased part can improve the therapeutic effect and reduce the suffering of patients.

Description

technical field [0001] The invention relates to the modification of cellulose, in particular to a preparation method of a modified carboxymethyl cellulose carrier with targeting effect, and belongs to the field of polymer functional materials. Background technique [0002] Cellulose is the most abundant natural organic renewable resource on the earth, but unfortunately a lot of cellulose has not been rationally utilized. The typical waste of resources is burning straw, which not only wastes resources, but also seriously pollutes the environment. It can be seen that cellulose is rich in sources, low in price, and has many advantages such as non-toxic environmental protection, good biocompatibility, and degradability, and has a good application prospect in the field of medicine. [0003] "Targeting" is a new term in the field of medicine. It refers to the delivery method that selectively concentrates the drug on the lesion site through the carrier. This technology has epoch-ma...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B11/12C08B1/08A61K47/38
Inventor 赵兰
Owner 江苏派克斯特纤维素有限公司