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Preparation method of a controllable porous ceramic/polymer matrix composite bone scaffold

A bone scaffold and polymer technology, applied in the field of bionic manufacturing science, can solve the problem that the bone scaffold cannot meet the requirements of tissue engineering, and achieve the effect of overcoming the uncontrollable and random channel structure, wide application range, and improving biological performance

Inactive Publication Date: 2016-05-11
CENT SOUTH UNIV
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Problems solved by technology

In order to improve the mechanical properties of the scaffold while ensuring the biological performance, and solve the problem that a single type of bone scaffold cannot meet the requirements of tissue engineering, the present invention proposes a composite powder that uses polyvinyl alcohol powder and calcium silicate powder as raw materials and mixes them. And use the selective laser sintering process to prepare a controllable porous ceramic / polymer matrix composite bone scaffold, so as to improve its comprehensive performance

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  • Preparation method of a controllable porous ceramic/polymer matrix composite bone scaffold
  • Preparation method of a controllable porous ceramic/polymer matrix composite bone scaffold

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Embodiment Construction

[0019] The specific embodiment of the present invention is set forth below by an example:

[0020] Polyvinyl alcohol powder and calcium silicate ceramic powder are used as raw materials, among which polyvinyl alcohol is purchased from Japan Synthetic Chemical Company, the average molecular modulus is 89000-98000g / mol, the degree of polymerization is 1700, and the particle size is 20-200μm; silicic acid Calcium was purchased from Kunshan Huaqiao Technology New Material Co., Ltd., with an average particle size of 1 μm and a purity of 98%. It was prepared by chemical precipitation.

[0021] A homogeneously mixed polyvinyl alcohol / calcium silicate composite powder was obtained after grinding for 1 h by mechanical mixing, wherein the mass fraction of calcium silicate was 10 wt%.

[0022] Using the self-developed selective laser sintering system, the selective laser sintering of polyvinyl alcohol / calcium silicate mixed powder is carried out under the process conditions of laser powe...

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Abstract

An ideal bone scaffold not only needs to have good biological performance, and is more in need of good mechanical properties. In order to guarantee biological performance meanwhile improve the mechanical properties of the scaffold to solve the problem that a single type bone scaffold cannot meet the requirements of tissue engineering, the invention discloses a preparation method of a controllable porous ceramic / polymer-based composite bone scaffold, and the method is particularly as follows: organic polymer material of polyvinyl alcohol (PVA) powder and inorganic ceramic material calcium silicate (CaSiO3) as raw materials are mechanically mixed to obtain composite powder, the composite powder is prepared into the natural bone tissue-like porous ceramic / polymer-based composite bone scaffold by selective laser sintering process, and the advantages of different materials are combined to improve the comprehensive performance.

Description

technical field [0001] The invention relates to a method for preparing a controllable porous ceramic / polymer matrix composite bone support, which belongs to the field of bionic manufacturing science. Specifically, the organic polymer material polyvinyl alcohol (PVA) and the inorganic ceramic material calcium silicate (CaSiO 3 ) mixed to obtain a composite powder, and the selective laser sintering process was used to prepare a porous ceramic / polymer matrix composite bone scaffold similar to natural bone tissue, in order to combine the advantages of different materials. technical background [0002] In bone tissue engineering, scaffolds not only provide support and protection for cell growth, but more importantly, the interaction between scaffolds and cells can regulate the morphogenetic process of cells and affect cell survival, migration, proliferation and functional metabolism. Therefore, it is very important and urgent to prepare scaffolds that are conducive to cell adhes...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/16A61L27/02A61L27/10A61L27/56
Inventor 帅词俊彭淑平毛中正
Owner CENT SOUTH UNIV
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