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A kind of pharmaceutical composition for treating osteoporosis and preparation method thereof

An osteoporosis and composition technology, applied in the field of medicine, can solve the problems of increased leucorrhea, ineffective bone microstructure, breast swelling, etc., and achieves the effects of improving quality of life, satisfying long-term medication, and alleviating bone pain.

Active Publication Date: 2016-08-24
HEBEI YUZHILIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Estrogen is the drug of choice for preventing and treating postmenopausal osteoporosis, but it can easily cause increased leucorrhea, breast swelling, and irregular uterine bleeding, with an incidence rate of about 10%. It has been reported that estrogen can increase the incidence of breast cancer and uterine cancer , so there are serious security risks, and should be used with caution
In addition to estrogen, calcium preparations and other chemical drugs used to prevent and treat osteoporosis cannot improve the destruction of bone microstructure, and the side effects are serious, and the purpose of long-term use to prevent and treat osteoporosis cannot be achieved
Under the guidance of TCM theory, use traditional Chinese medicine (such as calcium-containing Chinese patent medicine Longmu Zhuanggu Granules, Zhuanggujiewan Pills, Pearl Niuhuang Powder, Zhenzhu Zhenjing Pills, Wuji Baifeng Pills, Cynomorium Gujing Dan, Zhuhuang Powder, Pearl layer tablets, Pearl Babao Dan, etc.) to prevent and treat osteoporosis, the safety is relatively high, but because traditional Chinese medicine is the regulation of systemic functions, the onset of effect is slow, the patient's compliance is not good, and the purpose of preventing and treating osteoporosis cannot be achieved
There are also pharmaceutical compositions for the prevention and treatment of osteoporosis by several methods simultaneously on the market. For example, the "Manual for the Prevention and Treatment of Osteoporosis in the Chinese Population 2013 Edition" proposes to choose calcium preparations, estrogen receptor modulators, anabolic hormone preparations, Calcium preparations, active vitamin D3 preparations, vitamin preparations, ipropoxyflavone preparations and other preparations are adjusted, but the problem is still the absorption and metabolism of calcium, which has no effect on bone microstructure, so good curative effect cannot be obtained

Method used

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  • A kind of pharmaceutical composition for treating osteoporosis and preparation method thereof
  • A kind of pharmaceutical composition for treating osteoporosis and preparation method thereof
  • A kind of pharmaceutical composition for treating osteoporosis and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment Construction

[0028] The content of the present invention will be further described in detail below in conjunction with specific embodiments.

[0029] For the composition of the pharmaceutical ingredients of the present invention, the following examples are listed, see Table 1:

[0030] Table 1

[0031]

Example 1

Example 2

Example 3

Example 4

Example 5

Collagen

20

23

25

29

30

Chondroitin Sulfate Sodium Salt

25

22

20

17

15

Calcium carbonate

270

260

250

240

230

Drynaria fortunei extract

60

64

65

61

60

Pueraria Extract

40

36

35

32

30

D-glucosamine hydrochloride

50

53

55

58

60

Sanqi

60

58

50

45

40

[0032] In the specific production, the Drynaria fortunei extract and Pueraria lobata root extract were prepared first. Example 3 is the best experimental group.

[0033] The preparation process of the Drynaria fortunei extract is: immersing the Drynaria fortunei with 10 times the amount of solvent for 0.5h and then decocting twice for 1.5h each time. Combine the decoction and filter with 120 mesh to obtain the extract. ...

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Abstract

The invention discloses a medicine composition for treating osteoporosis and a preparation method thereof. The medicine composition is prepared from collagen, chondroitin sulfate sodium salt, calcium carbonate, rhizoma drynariae extract, kudzu vine root extract, D-glucosamine hydrochloride and pseudo-ginseng. The medicine composition can be used for treating the pathogenesis, namely destruction of bone microstructure, of osteoporosis, is capable of solving the problem of bone density abnormality and radically preventing and treating osteoporosis; and the medicine composition can be used for relieving symptoms of ostealgia of osteoporosis patients, healing of bone fracture can be promoted, and the living quality of osteoporosis patients can be improved.

Description

Technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition capable of repairing bone microstructure and increasing bone density, thereby achieving the purpose of treating osteoporosis and a preparation method thereof. Background technique [0002] With the entry of the aging society and the rapid increase of the elderly population, osteoporosis has become a serious public health problem. At present, there are more than 1.5 million osteoporosis-related fractures in the United States each year, while the number of elderly people over 60 in my country is 132 million, and there are about 90 million osteoporosis patients. It can be seen that the diagnosis and treatment of osteoporosis has become a top priority. [0003] As defined by the World Health Organization, osteoporosis is a systemic bone disease characterized by low bone mass and destruction of bone microstructure, leading to increased bone fragility...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/39A61P19/10A61K36/488A61K33/10A61K36/11A61K36/258A61K31/737A61K31/7008
Inventor 朱志铭金建文赵大鹏张赞王翠婷
Owner HEBEI YUZHILIN PHARMA
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