Green environmentally-friendly industrial sinomenine extraction and separation method

Abstract

The invention relates to a green environmentally-friendly industrial sinomenine extraction and separation method, sinomenine aw material powder as a raw material is added with slaked lime accounting 10% by weight of the raw material for even mixing, then is sprayed to wet with water and placed for a plurality of hours for alkalization, the alkalized material is put into an extracting tank, and added with a certain amount of ethyl acetate solvent for refluxing and extracting for 3 times, the extract in the extracting tank is filtered and sucked into a concentrator for vacuum concentration, the concentrated liquid is placed in the extracting tank, hydrochloric acid is added for adjusting pH to 4-5 for extraction, the hydrochloric acid layer is released, activated carbon is used for decolorization, pH is adjusted to about 2, and the liquid is placed overnight for precipitation of sinomenine hydrochloride. The traditional high toxicity benzene extraction and chloroform extraction processes are substituted by use of ethyl acetate as the extraction solvent, the problems of pollution on the environment and harm on human and animal health of existing technology can be solved, and sinomenine hydrochloride product can be directly obtained without crystallization of a product in a crude extract.

Description

technical field [0001] The invention relates to a green and environment-friendly industrialized extraction and separation method for sinomenine. Background technique [0002] Sinomenium acutum (Sinomenium acutum) is the dry cane of the plant medicines of the genus Fangji in the genus Fangji. It grows in mountains and is distributed in Shaanxi, Sichuan, Guizhou, Hubei, Guangxi, Guangdong, Fujian, Zhejiang, Jiangsu, Anhui, Henan etc., as a traditional Chinese medicine, it is used for rheumatic arthralgia, joint swelling, numbness and itching, and has the effect of dispelling wind and dehumidification and dredging channels and collaterals. Since the 1920s, Japanese and domestic scholars have isolated and discovered dozens of alkaloids from S. sinensis, and proved that sinomenine is the main active ingredient, with a content of 0.5% to 2% in plants. Pharmacological activity studies have shown that sinomenine has various pharmacological activities such as anti-inflammatory, immu...

AI Technical Summary

Problems solved by technology

[0007] The technical problems solved by the present invention are mainly embodied in two aspects. One is to use environmental protection, non-toxic and low The ethyl acetate of cost carries out the extraction of sinomenine as solvent; The 2nd, under the situation that product sinomenine does not crystallize in ethyl acetate concentrate in the new solvent extraction method, directly adopt hydrochloric acid to obtain sinomenine hydrochloride