Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Nanofiber bone cartilage repairing stent for tissue engineering and preparation method thereof

A nanofiber and tissue engineering technology, applied in the field of tissue engineering nanofiber osteochondral repair scaffold and its preparation, can solve the problems affecting the repair of cartilage layer and subchondral bone layer, easy to migrate and grow into each other, so as to improve the overall physical and chemical properties, The production cost is low and the effect of promoting regeneration

Inactive Publication Date: 2015-02-04
DONGHUA UNIV
View PDF5 Cites 16 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent (CN 102872480A) discloses a biphasic osteochondral tissue engineering scaffold, the cartilage layer and subchondral bone layer are both porous structures, but microscopically it is not the nanofibrous structure of bionic ECM
Moreover, since the two layers are connected porous structures, it is easy for the related cells of the cartilage layer and the subchondral bone layer to migrate and grow into each other, which affects the repair of the functions of the cartilage layer and the subchondral bone layer.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Nanofiber bone cartilage repairing stent for tissue engineering and preparation method thereof
  • Nanofiber bone cartilage repairing stent for tissue engineering and preparation method thereof
  • Nanofiber bone cartilage repairing stent for tissue engineering and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] like figure 1 As shown, the tissue engineering nanofibrous osteochondral repair scaffold of the present invention is composed of a porous cartilage layer 1, a porous subchondral bone layer 3 and a connecting layer 2 arranged between the porous cartilage layer 1 and the porous subchondral bone layer 3. The porous cartilage layer 1 includes a PLLA-based composite degradable polymer material, which is a porous nanofiber structure, with a pore size of 20 to 60 μm and a thickness of 1 mm; the connecting layer 2 includes a PLLA-based composite degradable polymer material, which is a porous nanofiber structure. , the pore diameter is less than 5 μm, and the thickness is 0.4 mm; the porous subchondral bone layer 3 includes a PLLA-based composite degradable polymer material containing 20% ​​nano-hydroxyapatite, which is a porous nanofiber structure with a pore diameter of 60-400 μm and a thickness of 1.8 mm.

[0026] The preparation method of the tissue engineering nanofiber os...

Embodiment 2

[0032] The tissue engineering nanofibrous osteochondral repair scaffold of the present invention is composed of a porous cartilage layer, a porous subchondral bone layer, and a connecting layer arranged between the porous cartilage layer and the porous subchondral bone layer, and the porous cartilage layer includes PLLA-based The composite degradable polymer material is a porous nanofiber structure with a pore size of 20-60 μm and a thickness of 1.5 mm; the connecting layer includes a PLLA-based composite degradable polymer material with a porous nanofiber structure with a pore size of <5 μm and a thickness of 0.5 mm The porous subchondral bone layer includes PLLA-based composite degradable polymer materials containing 30% nano-hydroxyapatite, which is a porous nanofiber structure with a pore size of 60-500 μm and a thickness of 2.5 mm.

[0033] The preparation method of the tissue engineering nanofiber osteochondral repair scaffold is as follows:

[0034] (1) Dissolve PLLA an...

Embodiment 3

[0039] The tissue engineering nanofibrous osteochondral repair scaffold of the present invention is composed of a porous cartilage layer, a porous subchondral bone layer, and a connecting layer arranged between the porous cartilage layer and the porous subchondral bone layer, and the porous cartilage layer includes PLLA-based The composite degradable polymer material is a porous nanofiber structure with a pore size of 20-60 μm and a thickness of 2 mm; the connecting layer includes a PLLA-based composite degradable polymer material with a porous nanofiber structure with a pore size of <5 μm and a thickness of 0.5 mm; The porous subchondral bone layer includes PLLA-based composite degradable polymer material containing 40% nano-hydroxyapatite, which is a porous nanofiber structure with a pore diameter of 60-400 μm and a thickness of 2.5 mm.

[0040] The preparation method of the tissue engineering nanofiber osteochondral repair scaffold is as follows:

[0041] (1) Dissolve PLLA ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
pore sizeaaaaaaaaaa
pore sizeaaaaaaaaaa
thicknessaaaaaaaaaa
Login to View More

Abstract

The invention discloses a nanofiber bone cartilage repairing stent for tissue engineering and a preparation method thereof. The nanofiber bone cartilage repairing stent for tissue engineering is characterized by comprising a porous cartilage layer, a porous cartilage lower bone layer and a connecting layer between the porous cartilage layer and the porous cartilage lower bone layer, wherein the porous cartilage layer includes a PLLA-based composite degradable polymer material and is of a porous nanofiber structure which is 20-400mu m in pore diameter; the connecting layer includes a PLLA-based composite degradable polymer material and is of a porous nanofiber structure which is less than 5mu m in pore diameter; and the porous cartilage lower bone layer comprises a PLLA-based composite degradable polymer material containing 5-70% (w / w) of nano-hydroxyapatite and is of a porous nanofiber structure which is 50-500mu m in pore diameter. Microstructure of the bone cartilage repairing stent prepared by the invention is represented as bionic ECM nanofiber; the repairing stent can promote adhesion, propagation and differentiation of related bone cartilage cells on the stent, and can also promote transportation of nutrient substances in the stent and discharge of metabolic waste.

Description

technical field [0001] The invention belongs to the technical field of osteochondral tissue engineering scaffolds, in particular to a tissue engineering nanofiber osteochondral repair scaffold and a preparation method thereof. Background technique [0002] The damage and lesions of articular cartilage are common orthopaedic diseases in clinic, and it is difficult to self-repair. Moreover, the damage of the cartilage at the joint is often accompanied by the joint damage of the subchondral bone layer, so the repair of the cartilage also needs to repair the subchondral bone. At present, the commonly used clinical treatment method is autologous or allogeneic osteochondral transplantation, which has achieved a certain therapeutic effect, but there are also shortcomings. The source of autologous osteochondral is limited, and it will cause secondary damage to patients. risk of disease transmission. The development of tissue engineering provides a new way to construct osteochondra...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/46A61L27/56
Inventor 何创龙王伟忠仇可新周小军贾亚听
Owner DONGHUA UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com