Application of bilobalide composition in preparation of medicine for preventing/treating glaucoma

A technology of ginkgolides and total ginkgolides, applied in the field of pharmaceutical compositions, can solve problems such as untreated glaucoma, achieve the effects of improving blood supply to the optic nerve, reducing intraocular pressure, and great clinical application value

Inactive Publication Date: 2015-02-18
SHANGHAI SINE PROMOD PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no Chinese medicine that is par

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1 preparation of total ginkgo lactones

[0017] Ginkgo biloba (the used raw material ginkgo biloba is commercially available) is dried at 60°C until the moisture content is less than 5%, pulverized by a pulverizer, 10kg of ginkgo leaf powder is taken, 40L of 80% ethanol is added, the leaves are submerged, and heated to 60°C for reflux Extract for 4 hours, collect the extract, make up the extract with 70% ethanol to 40L, reflux at 60°C for 4 hours, collect the extract; combine the two extracts and let stand for 24 hours, discard the sediment, take the supernatant and wash at 50°C Concentrate under reduced pressure, when the extract is concentrated to 5L, pass through the macroporous resin column D101, first elute with 30% ethanol solution to remove impurities, a total of 3BV is eluted, and the elution speed is 1BV / h, and then use 60% ethanol in the same manner Elute the resin at a flow rate, collect 60% of the eluate from 2BV to 10BV, and concentrate the eluat...

Embodiment 2

[0026] Embodiment 2 Ginkgo biloba total lactone preparation

[0027] Ginkgo biloba (the used raw material ginkgo biloba is commercially available) is dried at 60°C until the moisture content is less than 5%, pulverized by a pulverizer, 5kg of ginkgo leaf powder is taken, 20L of 80% ethanol is added, the leaves are submerged, and heated to 60°C for reflux Extract for 4 hours, collect the extract, make up the extract with 70% ethanol to 40L, reflux at 60°C for 4 hours, collect the extract; combine the two extracts and let stand for 24 hours, discard the sediment, take the supernatant and wash at 50°C Concentrate under reduced pressure, when the extract is concentrated to 5L, pass through the macroporous resin column D101, first elute with 30% ethanol solution to remove impurities, a total of 3BV is eluted, and the elution speed is 1BV / h, and then use 60% ethanol in the same manner Elute the resin at a flow rate, collect 60% of the eluate from 2BV to 10BV, and concentrate the elu...

Embodiment 3

[0036] Example 1 Prepare 10 g of total ginkgo biloba lactones, crush it into 100-mesh fine powder, add 100 g of lactose, mix well, boil and granulate, add micronized silica gel 3 g, magnesium stearate 2 g to the granules, mix well, pack 2# capsules , made into 1000 capsules, used to prevent or treat glaucoma, usage method: take orally, one capsule each time, twice a day.

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Abstract

The invention discloses an application of a bilobalide composition to preparation of a medicine for preventing/treating glaucoma. The bilobalide composition consists of total lactone of ginkgo and medicinal auxiliary materials, wherein the total lactone of ginkgo is used as an active component of the bilobalide composition. The total lactone of ginkgo mainly comprises bilobalide A, bilobalide B, bilobalide C and bilobalide, and HPLC-ELSD detection shows that the content of the total lactone is 80.0% to 99.9%. The bilobalide composition disclosed by the invention is subjected to curative effect detection and safety detection and the results show that the bilobalide composition has the effects of reducing intraocular pressure, expanding blood vessels, increasing blood flow volume, improving blood supply of optic nerves and the like, can be used for preparing the medicine for preventing/treating glaucoma diseases, provides a new traditional Chinese medicine for treating the glaucoma diseases in clinical application and has relatively large clinical application value and relatively good social benefits.

Description

technical field [0001] The present invention relates to a pharmaceutical composition, in particular to a traditional Chinese medicine extract composition, in particular to a ginkgolide composition obtained by extracting, purifying and refining ginkgo biloba leaves as a raw material, and its preparation and application. Background technique [0002] Glaucoma includes congenital glaucoma, primary glaucoma, secondary glaucoma and mixed glaucoma. It is a common disease in ophthalmology, which is extremely harmful to vision and is also one of the most common blinding eye diseases. Glaucoma often has symptoms such as increased intraocular pressure accompanied by pericorneal congestion, dilated pupils, sharp loss of vision, headache, and vomiting. . When the intraocular pressure of glaucoma exceeds the limit that the intraocular tissue, especially the retina, can bear, it will cause eye functional lesions and bring great pain to the majority of patients. The clinical manifestatio...

Claims

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Application Information

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IPC IPC(8): A61K36/16A61P27/06
CPCA61K36/16A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2236/55
Inventor 胡林森李丁孙蓉梅锦平徐继红
Owner SHANGHAI SINE PROMOD PHARMA
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