A kind of aseptic freeze-dried powder of fosaprepitant dimeglumine for injection and preparation process thereof

A technology for fosaprepitant dimeglumine and injection, which is applied in the field of sterile freeze-dried powder of fosaprepitant dimeglumine for injection and its preparation, can solve problems such as inability to guarantee drug stability, and achieve avoidance Allergy and hemolysis, low cost, simple and controllable preparation method
CN104414983BActive Publication Date: 2018-09-04SHANDONG NEWTIME PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHANDONG NEWTIME PHARMA
Publication Date
2018-09-04

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Abstract

The invention particularly relates to a sterile freeze-dried fosaprepitant-dimeglumine powder for injection and a preparation process of the sterile freeze-dried fosaprepitant-dimeglumine powder. The sterile freeze-dried fosaprepitant-dimeglumine powder for injection comprises an active component, a solubilizing agent and a pH-value adjusting agent, wherein the active component is fosaprepitant dimeglumine. The preparation process of the sterile freeze-dried fosaprepitant-dimeglumine powder for injection is simple and feasible and is suitable for scale production. The sterile freeze-dried fosaprepitant-dimeglumine powder for injection has high quality and excellent stability and can be stored for a long time.
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Description

technical field

[0001] The invention belongs to the technical field of medicine, and in particular relates to a sterile freeze-dried powder of fosaprepitant dimeglumine for injection and a preparation process thereof. Background technique

[0002] Fosaprepitant Dimeglumine (Fosaprepitant Dimeglumine) is the prodrug of aprepitant (aprepitant), which is rapidly converted into aprepitant in the body after injection. This product, like aprepitant, belongs to the human substance P / neurokinin 1 (NK-1) selective high-affinity receptor blocker, which mainly acts by blocking the nausea and vomiting signals in the brain. In animal models, aprepitant inhibits emesis induced by cytotoxic chemotherapeutic drugs such as cisplatin through central nervous effects. Animal and human positron emission tomography (PET) studies have shown that aprepitant penetrates the blood-brain barrier and occupies the brain NK-1 receptor. Animal and clinical studies have shown that aprepitant increases the...

Claims

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