A kind of separation and purification method of doramectin

A doramectin, separation and purification technology, applied in chemical instruments and methods, organic chemistry, preparation of sugar derivatives, etc., can solve problems such as inability to meet drug quality requirements, unfavorable industrial production, and low product purity, and achieve production costs. Low, environmentally friendly, simple process effect
CN104418927BActive Publication Date: 2018-03-27CHONGQING QIANTAI BIOLOGICAL MEDICINE +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
CHONGQING QIANTAI BIOLOGICAL MEDICINE
Publication Date
2018-03-27

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Abstract

The invention discloses a separation and purification method of doramectin. The method comprises the following steps: separating doramectin from fermentation liquor by extraction; then, decoloring by virtue of active carbon; and performing steps such as a programmed cooling crystallization method and the like to obtain a high purity doramectin product. The method disclosed by the invention has the advantages that doramectin is separated and purified by adopting the programmed cooling crystallization method, so that the method is high in product yield and purity, simple and feasible in process, low in production cost and suitable for industrial production.
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Description

technical field

[0001] The invention belongs to the field of medicinal chemistry, and in particular relates to a separation and purification method of doramectin. Background technique

[0002] Doramectin (DRM) is the third-generation derivative of the macrolide antibiotic abamectin, produced by Streptomyces avermitilis ( Streptomyces avermitilis ) genetically engineered mutant strains were biosynthesized by adding cyclohexyl carboxylic acid to obtain a sixteen-membered macrolide semi-synthetic antibiotic, and the difference from ivermectin was in C 25 There is a cyclohexyl group in the position. The chemical name is 25-cyclohexyl-5-O-demethyl-25-de(1-methylpropyl) abamectin B1, and its chemical nature belongs to macrolide antibiotics, and its molecular formula is C 50 h 74 o 14 , Molecular weight is 899.11, melting point: 116°C-119°C, high fat solubility, easily soluble in organic solvents, such as methanol, ethanol, acetone, 1,2-propylene glycol, ethyl acetate, dimethyl...

Claims

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