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A metal support with micro-nano structure on the surface

A technology of micro-nano structure and metal stent, which is applied in the direction of human tubular structure devices, stents, blood vessels, etc., can solve the problems of uneven drug release, endothelial growth delay, stent thrombosis, etc., and achieve the goal of overcoming restenosis and facilitating clinging Effect

Active Publication Date: 2017-06-09
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, the currently commonly used drug-eluting stents include rapamycin-eluting stents and paclitaxel-eluting stents, etc., which can reduce the restenosis rate to less than 10% by inhibiting the proliferation of smooth muscle cells, but inhibit the proliferation of smooth muscle cells while causing endothelial Growth delay, late stent thrombosis, aneurysms, uneven drug release, etc.

Method used

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  • A metal support with micro-nano structure on the surface
  • A metal support with micro-nano structure on the surface

Examples

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Effect test

Embodiment 1

[0018] As shown in Figures 1a to 1c, a metal stent with a micro-nano structure on the surface, the stent structure is the same as that of the existing bare metal stent, and the feature is that the surface of the metal stent has a micro-nano structure.

[0019] Referring to Fig. 1a, it is a picture of the metal stent structure with micro-nano structure on the surface of the present invention. The structure and material of the metal stent of the present invention are the same as the metal stent before the drug-eluting stent (DES) of the prior art is coated with a coating, the difference is that the metal stent with micro-nano structure on the surface of the present invention needs Micro-nano structures are processed on the surface of the metal support in the prior art.

[0020] Referring to FIG. 1 b , it is a micrograph of a metal stent with a micro-nano structure on the surface of the present invention. Under a certain magnification, it can be seen that the surface of the metal...

Embodiment 2

[0025] The surface of the metal stent described in this embodiment has a micro-nano structure. The micro-nano structure processed on the surface of the metal stent in the prior art is the same as that in Example 1. The difference is that the surface of the metal stent is coated with Covered with biodegradable polymer material coating. It should be pointed out that although the surface of the metal stent is coated with a biodegradable polymer material coating, there is no need to load drugs, genes, antibodies or block polymers, etc. Obviously, this is different from the coating of the surface of the metal stent in the prior art. There are obvious differences between coating with biodegradable polymer materials and loading drugs, genes, antibodies or block polymers.

[0026] The biodegradable polymer material selected in this example should have such properties: it is very easy to combine with the metal scaffold with micro-nano structure on the surface, and it is easy to quickly...

Embodiment 3

[0030] The current clinical research on coronary stents is mainly devoted to surface modification of stents in order to reduce the occurrence of thrombus and intimal hyperplasia. There are two main ways of modification. The first way is to change the physical and chemical properties of the scaffold surface through physical and chemical methods, and the second way is to load drugs, genes, cells, etc. through suitable carriers. Examples 1 and 2 adopted the first approach: using multi-beam laser processing to prepare micro-nano structures on the surface of the metal stent, which expanded the adsorption area and created conditions for rapid adsorption of endothelial cells and rapid endothelialization. When using the second approach, the carrier is generally a degradable polymer material, but some suitable carriers cannot be used because they cannot be firmly adsorbed to the metal stent. After the micro-nano structures are prepared on the surface of the metal stent by using multi-b...

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Abstract

The invention relates to a metal support with a micro-nano structure on the surface and belongs to the technical field of intravascular intervention in the department of cardiology. According to the metal support with the micro-nano structure on the surface, the support structure is the same as that of an existing bare metal support. The metal support with the micro-nano structure on the surface is characterized in that the micro-nano structure is arranged on the surface of the metal support. The structure and the material of the metal support are the same as those of a metal support of a drug eluting support (DES) which is not coated with a coating in the prior art. According to the difference, the micro-nano structure needs to be machined on the surface of the metal support in the prior art. The metal support has the advantages that due to the construction of the micro-nano structure on the surface of the support, growth of endothelial cells is facilitated, and the micro-nano structure is consistent with the coronary artery hemodynamics; the bionic structure is arranged on the surface of the support and is closer to the growth environment in a human body, the endothelial cells can be attached to the bionic structure easily, re-endothelialization is accelerated, and restenosis caused by hyperplasia of vascular smooth muscle cells and thrombus formed in an anaphase coronary stent are avoided.

Description

technical field [0001] The invention relates to a metal stent with a micro-nano structure on the surface, which belongs to the technical field of vascular intervention in cardiovascular medicine. Background technique [0002] The present invention belongs to inventions for overcoming prejudices. [0003] In recent years, the incidence of coronary heart disease in my country has been increasing year by year and showing a younger trend. Percutaneous coronary stenting is currently the main method for the treatment of coronary heart disease. [0004] Intracoronary balloon dilatation (PTCA), bare metal stent (BMS), and drug-eluting stent (DES) are three historic leaps in interventional treatment of coronary heart disease. PTCA, BMS, DES can all cause restenosis. The cause of restenosis is that stent expansion causes vascular intima damage to activate platelets and related cells, and various cytokines released by them can activate vascular smooth muscle cells and inflammatory c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/07
Inventor 王珺楠刘永利王金鹏艾永顺张静崔燕武军铎李智博
Owner JILIN UNIV
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