Pullulan polysaccharide capsule and preparation process thereof

Abstract

The invention relates to a production method of a pharmaceutical capsule, namely a hollow pullulan polysaccharide capsule and a preparation process thereof. The pullulan polysaccharide capsule disclosed by the invention is characterized by being prepared from the following components in parts by weight: 80-99.5 parts of pullulan polysaccharide, 0.001-12 parts of gel, 0.1-5 parts of a coagulant aid, 0.1-5 parts of a cosolvent, 0.001-5 parts of a surface active agent, and 10-14 parts of water. The pullulan polysaccharide capsule and the preparation process thereof disclosed by the invention have the beneficial effects that the pullulan polysaccharide capsule is steady in property, good in transparency, difficult to become fragile, low in production cost, free from animal component and safe to use; the surface of the pullulan polysaccharide capsule cannot become fogged and yellow after being placed for a long time; the water content of the pullulan polysaccharide capsule is obviously lower than that of a gelatin capsule; therefore, the pullulan polysaccharide capsule is more suitable to be filled in hygroscopic drugs and aldehyde-containing drugs; the physicochemical indexes of the pullulan polysaccharide capsule accord with hollow shell capsule standards specified by the national formulary; the pullulan polysaccharide capsule satisfies requirements of different religious cultures; and therefore, the pullulan polysaccharide capsule has a wide market prospect and practical value.

Description

technical field [0001] The invention relates to a production method of a medicinal capsule, namely a pullulan capsule and a preparation process thereof. Background technique [0002] Capsule preparation is to pack medicine or health care product in a hollow capsule for easy taking. Traditional capsules are made of gelatin and auxiliary materials. The disadvantage of this capsule is that the amino acids in the gelatin may produce a cross-linking reaction, resulting in drug disintegration or reduced dissolution performance. The gelatin used is mostly obtained by hydrolyzing the skin and bones of animals such as pigs and cattle. It is not suitable for people of certain religions and vegetarians, and its application is limited. In order to solve the above problems, the industry has done a lot of research and found a variety of substitute materials for gelatin, such as cellulose and its derivatives such as hydroxypropyl methylcellulose (HPMC), soybean polysaccharide, potato sta...

AI Technical Summary

Problems solved by technology

The disadvantage of this type of capsule is that the amino acids in the gelatin may produce cross-linking reactions, resulting in drug disintegration or reduced dissolution performance

However, the current pullulan capsule preparation process is still immature, and the product quality is unstable. Some products have disadvantages such as high water content, easy brittleness, difficulty in disintegration, foggy and yellowish surface after long-term storage, and urgently need to be optimized. Complete