Pullulan polysaccharide capsule and preparation process thereof

A technique for the preparation of pullulan polysaccharide, which is applied in the field of pullulan capsules and its preparation technology, can solve the problems of drug disintegration and dissolution performance, high water content, and difficult disintegration, and achieve broad market prospects and practical value , low production cost, good transparency

Inactive Publication Date: 2015-03-25
TONGLIAO MEIHUA BIOLOGICAL SCI TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage of this type of capsule is that the amino acids in the gelatin may produce cross-linking reactions, resulting in drug disintegration or reduced dissolution performance
However, the current pullulan capsule preparation process is still i

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0016] The first example: add 155kg of pure water to a 600L sol tank, raise the temperature to 90°C, turn on the stirring, slowly add 35kg of pullulan, 875g of gellan gum, 120g of potassium chloride, 200g of glycerin, and cross-linked carboxymethyl Sodium cellulose 500g, sodium lauryl sulfate 30g, mix and stir for 1.5hr until a uniform solution is formed, vacuumize and defoam under slow stirring, then cool down to 65°C and let stand.

[0017] According to the specifications and sizes of the gelatin hard-shell hollow capsules, the hard capsule shells are prepared by the traditional glue-dipping method on the full-automatic production line of the gelatin hollow capsules, dried at 25-45°C, and the moisture content is controlled to 10-14%. The obtained hard-shell hollow capsules have good transparency and elasticity, good taste and high strength, and the filling rate of the medicines is higher than that of traditional gelatin capsules. After testing, the pullulan hard-shell capsul...

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PUM

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Abstract

The invention relates to a production method of a pharmaceutical capsule, namely a hollow pullulan polysaccharide capsule and a preparation process thereof. The pullulan polysaccharide capsule disclosed by the invention is characterized by being prepared from the following components in parts by weight: 80-99.5 parts of pullulan polysaccharide, 0.001-12 parts of gel, 0.1-5 parts of a coagulant aid, 0.1-5 parts of a cosolvent, 0.001-5 parts of a surface active agent, and 10-14 parts of water. The pullulan polysaccharide capsule and the preparation process thereof disclosed by the invention have the beneficial effects that the pullulan polysaccharide capsule is steady in property, good in transparency, difficult to become fragile, low in production cost, free from animal component and safe to use; the surface of the pullulan polysaccharide capsule cannot become fogged and yellow after being placed for a long time; the water content of the pullulan polysaccharide capsule is obviously lower than that of a gelatin capsule; therefore, the pullulan polysaccharide capsule is more suitable to be filled in hygroscopic drugs and aldehyde-containing drugs; the physicochemical indexes of the pullulan polysaccharide capsule accord with hollow shell capsule standards specified by the national formulary; the pullulan polysaccharide capsule satisfies requirements of different religious cultures; and therefore, the pullulan polysaccharide capsule has a wide market prospect and practical value.

Description

technical field [0001] The invention relates to a production method of a medicinal capsule, namely a pullulan capsule and a preparation process thereof. Background technique [0002] Capsule preparation is to pack medicine or health care product in a hollow capsule for easy taking. Traditional capsules are made of gelatin and auxiliary materials. The disadvantage of this capsule is that the amino acids in the gelatin may produce a cross-linking reaction, resulting in drug disintegration or reduced dissolution performance. The gelatin used is mostly obtained by hydrolyzing the skin and bones of animals such as pigs and cattle. It is not suitable for people of certain religions and vegetarians, and its application is limited. In order to solve the above problems, the industry has done a lot of research and found a variety of substitute materials for gelatin, such as cellulose and its derivatives such as hydroxypropyl methylcellulose (HPMC), soybean polysaccharide, potato sta...

Claims

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Application Information

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IPC IPC(8): A61K47/36A61K9/48
Inventor 伊婷婷富春丽孙伟
Owner TONGLIAO MEIHUA BIOLOGICAL SCI TECH CO LTD
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