Di-p-toluoyl-D-tartaric acid synthetic method

Abstract

The invention discloses a Di-p-toluoyl-D-tartaric acid synthetic method. D-Tartaric acid and p-toluoyl chloride are taken as raw materials, copper sulfate is taken as a catalyst, toluene is taken as a solution, Di-p-toluoyl-D-tartaric anhydride is obtained through a reaction, an equivalent amount of water is added, and the toluene is hydrolyzed to obtain Di-p-toluoyl-D-tartaric acid, wherein the toluene solution, and water and the toluene in the hydrolysis can be recycled. The method is simple in process, safe and easy to operate, the process yield reaches over 95 percent; and at the same time, the cost of the raw materials is low, a part of raw material can be recycled, the purity of a finished product is high, and an excellent chiral resolution performance is achieved.

Description

technical field

[0001] The invention relates to the technical field of a chemical synthesis method of a chiral resolution reagent, in particular to a synthesis method of D-p-methyldibenzoyl tartaric acid. Background technique

[0002] D-p-methyldibenzoyl tartaric acid is a white crystalline powder that easily absorbs water in the air and is soluble in organic solvents such as ethanol and methanol. Widely used in chiral resolution of amine compounds. And because of its low price, stable properties, and easy recycling, it has good industrial application value. Its molecular formula is as follows:

[0003]

[0004] The defect of common synthetic method is: 1. raw material has strong irritation, strong corrosiveness, hypertoxicity, is difficult for handling. ② The utilization rate of raw materials is low, they cannot be recycled, and the production pollution is relatively large. ③The process yield is low, about 35%, the product purity is lower, and the production cost is ...

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