Construction method of standard finger-print and characteristic spectrum of Suoquan preparation and quality detection method

Abstract

The invention discloses a construction method of a standard finger-print and a characteristic spectrum of a Suoquan preparation. The construction method comprises the following steps: preparing a reference solution; preparing a solution of a test article; and determining the correlations among medicinal raw materials and a finished product. By adopting a multi-wavelength switching technology to determine and by taking a retention time and a peak area of a chromatographic peak of a reference article as 1, the relative retention time and relative peak area of the test article are calculated, so that the HPLC standard finger-print of the Suoquan preparation is obtained. According to the HPLC standard finger-print of the Suoquan preparation prepared by the method, the finger-print assigned to Chinese yam has five common peaks; the finger-print assigned to alpinia oxyphylla has four common peaks; and finger-print assigned to lindera aggregata has nine common peaks. The method disclosed by the invention can be used for achieving the purpose of increasing the quality coverage by adopting the multi-wavelength detection method, and can be used for improving the detection sensitivity and the detection quality and comprehensively, objectively and scientifically evaluating the quality of the Suoquan preparation. Particularly, the method can be used as one of the indexes for true and false identification of the Suoquan preparation.

Description

technical field

[0001] The invention belongs to the technical field of drug quality control, and in particular relates to a construction method and a quality detection method of a standard fingerprint and a characteristic map of a shrink spring preparation. Background technique

[0002] Shuquan preparation is composed of three medicinal materials: yam, Yizhiren and black medicine. Based on the ancient famous prescription Shuquan Wan, it is refined by using modern advanced equipment and extraction technology. The prescription of Shuoquan preparation is the key prescription for the treatment of kidney deficiency and coldness and urinary disorders in the past dynasties. In the prescription, Yizhiren warms and nourishes the yang of the kidney, solidifies Qi and astringent essence as the main drug; yam nourishes the Qi of the spleen and kidney, and enhances the effect of Yizhiren, and is used as an auxiliary drug; Wuyao Shunqi relieves stagnation, clears the body's meridians, qi...

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