Ropinirole hydrochloride sustained release tablets and preparation method thereof

A technology for ropinirole hydrochloride and sustained-release tablets, which is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, and drug delivery, can solve problems such as unproven, and achieve convenient storage, stable therapeutic effects, and preparation methods. Simple and easy effects

Inactive Publication Date: 2015-04-01
HARBIN SHENGJI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Genetic susceptibility. In recent years, the Alα53THr mutation of a common nuclide gene has been found in patients with familial Parkinson's disease, but it has not been confirmed many times later

Method used

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  • Ropinirole hydrochloride sustained release tablets and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] A ropinirole hydrochloride sustained-release tablet and a preparation method thereof, made of ropinirole hydrochloride, a sustained-release matrix material, and a lubricant, wherein, in parts by weight, 2 parts of ropinirole hydrochloride, a sustained-release matrix 50-95 parts of material, 3-20 parts of lubricant.

[0035] According to optimal parts by weight, 2 parts of ropinirole hydrochloride, 93 parts of slow-release matrix material, and 5 parts of lubricant.

[0036] The sustained-release matrix material is hypromellose.

[0037] The hypromellose is one or a mixture of 75hd100cr hypromellose, 75hd4000cr hypromellose, 75hd15000cr hypromellose, 100000cr hypromellose.

[0038] Described lubricant is magnesium stearate, talcum powder, silicon dioxide or a mixture of both.

Embodiment 2

[0040] A kind of ropinirole hydrochloride sustained-release tablet and preparation method thereof, the concrete steps of its preparation method are:

[0041] Step 1, material preparation: ropinirole hydrochloride is pulverized with a pulverizer, passed through a 100-mesh sieve, and set aside;

[0042] Step 2: Total mixing: weigh ropinirole hydrochloride and hypromellose in a three-dimensional mixer according to parts by weight and mix them for 30 minutes, then take them out for later use;

[0043] Step 3: Granulation: Put the mixed fine powder of raw and auxiliary materials into the wet granulator, use pure water as the binder, put the binder into the liquid supply tank, turn on the machine, adjust the parameters, and start adding the moistening Wet agent, open the shearing flying knife at the same time, 2-5 minutes, discharge, use a swing granulator, granulate with a 20-mesh nylon screen, dry with a fluidized bed dryer, first dry with cool wind, wait After the skin i...

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PUM

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Abstract

The invention provides ropinirole hydrochloride sustained release tablets. The ropinirole hydrochloride sustained release tablets are prepared from 2 parts by weight of ropinirole hydrochloride, 50-95 parts by weight of sustained release skeleton material and 3-20 parts by weight of lubricating agent. A preparation method of the ropinirole hydrochloride sustained release tablets comprises the steps of material preparing, blending, granulating, blending, tabletting and aluminium-plastic packaging. The ropinirole hydrochloride sustained release tablets and the preparation method have the beneficial effects that the ropinirole hydrochloride sustained release tablets can be used for effectively treating Parkinson diseases and adopt the novel sustained release preparations; sustained release refers to reducing the absorption rates of medicines into bodies by reducing the release rates of the medicines from the dosage forms, thus achieving more stable treatment effects; the ropinirole hydrochloride sustained release tablets have the advantages of good medicine stability, convenience in packaging, transportation and storage, and the like; the preparation method is simple and practicable and is suitable for industrial production.

Description

technical field [0001] The invention belongs to the field of chemical drug sustained-release preparations, in particular to a ropinirole hydrochloride sustained-release tablet and a preparation method thereof. Background technique [0002] Parkinson's disease, also known as idiopathic Parkinson's disease (PD), referred to as Parkinson's disease, also known as paralysis agitans (shaking palsy), is a common neurodegenerative disease in middle-aged and elderly people. The most common extrapyramidal system disease in humans, the main lesions are in the substantia nigra and striatum pathways, and the production of dopamine is reduced. The prevalence rate of people over 65 years old is 1000 / 100,000, increasing with age, and slightly more in men than women. [0003] Cause: [0004] Aging (25%): [0005] Parkinson's mainly occurs in the middle-aged and elderly people, and the onset is rare before the age of 40, suggesting that aging is related to the onset. Studies have found tha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K31/4045A61P25/16
Inventor 马玉国
Owner HARBIN SHENGJI PHARMA
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