Novel polypeptide with active tumor targeting and pH sensitive cell penetratingcapability

A sensitive and new technology, applied in anti-tumor drugs, peptides, hybrid peptides, etc., can solve problems such as side effects
CN104497149AInactive Publication Date: 2015-04-08SICHUAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SICHUAN UNIV
Publication Date
2015-04-08
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a novel polypeptide which not only can be actively targeted to highly expressed integrin receptor of tumor cells, but also can efficiently mediate cell entry. The novel polypeptide TR(c(RGDfK)-AGYLLGHINLHHLAHL(Aib)HHIL-Cys) is formed by connecting cyclic RGD peptide (c(RGDfK)) of specificity-targeted integrin receptor and non-specific pH sensitive cell penetrating peptide TH(AGYLLGHINLHHLAHL(Aib)HHIL-Cys) through covalent bonds. The novel polypeptide TR is modified onto the surface of a drug carrier system, and can mediate the drug carrier system to more efficiently deliver to the inside of the tumor, so that the tumor can be more effectively treated.
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Description

technical field

[0001] The present invention relates to the technical field of pharmaceutical preparations. Specifically, the present invention relates to a novel polypeptide which has both the ability to actively target the highly expressed integrin receptors of tumor cells and the ability of pH-sensitive cell membrane penetration. The novel polypeptide is modified on the surface of the drug-carrying system, and is used to mediate the drug-carrying system to efficiently and actively target tumors with high expression of integrin receptors and efficiently mediate their entry into cells, so as to achieve the purpose of improving the tumor treatment effect. Background technique

[0002] 1. The incidence and mortality of cancer have been increasing year by year in recent years, which has seriously threatened human health. Although there are various treatments for cancer, chemotherapy is still the most commonly used. Because chemotherapeutic drugs often lack selectivity betwee...

Claims

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