Preparation method of hyaluronic acid-chitosan degradable dressing

A technology of hyaluronic acid and chitosan, which is applied in medical science, absorbent pads, bandages, etc., can solve the problems of no antibacterial activity, limited application range, no ability to treat and repair wounds, etc., and achieve the purpose of diluting and eliminating scars, The process is simple and the effect of preventing scar hyperplasia

Inactive Publication Date: 2015-04-08
王剑
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, from a medical point of view, these traditional wound dressings have limited clinical application because they do not have the properties of treating and repairing wounds, nor do they have antibacterial activity.

Method used

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  • Preparation method of hyaluronic acid-chitosan degradable dressing

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] (1) Preparation of hyaluronic acid solution: the molecular weight Mw=1×10 6 g / mol hyaluronic acid is directly dissolved in deionized water, the mass concentration of hyaluronic acid is 0.5%, and then sodium chloride solid with a mass fraction of 0.5% is added to the hyaluronic acid aqueous solution, and magnetically stirred to dissolve;

[0025] (2) Preparation of chitosan solution: set molecular weight Mw=1×10 5 g / mol chitosan is dissolved in 1% dilute hydrochloric acid solution by mass fraction, stirred and dissolved to obtain a chitosan solution with a concentration of 5%;

[0026] (3) Cross-linking reaction: Mix the hyaluronic acid solution and chitosan solution at a mass ratio of 9:1, stir and mix evenly at room temperature, and add glutaraldehyde with a mass concentration of 0.1% into the solution as a cross-linking agent , stirred and reacted at temperature T=40°C for 8 hours, and the solution became a gel state;

[0027] (4) Dry molding: add fine pearl powde...

Embodiment 2

[0029] (1) Preparation of hyaluronic acid solution: the molecular weight Mw=1×10 6 g / mol hyaluronic acid is directly dissolved in deionized water, the mass concentration of hyaluronic acid is 0.5%, and then sodium chloride solid with a mass fraction of 0.5% is added to the hyaluronic acid aqueous solution, and magnetically stirred to dissolve;

[0030] (2) Preparation of chitosan solution: set molecular weight Mw=1×10 5 g / mol chitosan is dissolved in 1% dilute hydrochloric acid solution by mass fraction, stirred and dissolved to obtain a chitosan solution with a concentration of 5%;

[0031] (3) Cross-linking reaction: Mix the hyaluronic acid solution and chitosan solution at a mass ratio of 8:2, stir and mix evenly at room temperature, and add genipin with a mass concentration of 0.1% to the solution as a cross-linking agent , stirred and reacted at temperature T=40°C for 8 hours, and the solution became a gel state;

[0032] (4) Dry molding: add fine pearl powder and sal...

Embodiment 3

[0034] (1) Preparation of hyaluronic acid solution: the molecular weight Mw=1.5×106 g / mol hyaluronic acid is directly dissolved in deionized water, the mass concentration of hyaluronic acid is 1%, and then sodium chloride solid with a mass fraction of 0.5% is added to the hyaluronic acid aqueous solution, and magnetically stirred to dissolve;

[0035] (2) Preparation of chitosan solution: set molecular weight Mw=1×10 5 g / mol chitosan is dissolved in 1% dilute hydrochloric acid solution by mass fraction, stirred and dissolved to obtain a chitosan solution with a concentration of 5%;

[0036] (3) Cross-linking reaction: Mix the hyaluronic acid solution and chitosan solution at a mass ratio of 8:2, stir and mix evenly at room temperature, and add genipin with a mass concentration of 0.1% to the solution as a cross-linking agent , stirred and reacted at temperature T=60°C for 8 hours, and the solution became a gel state;

[0037] (4) Dry molding: add fine pearl powder and salvi...

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Abstract

The invention relates to a preparation method of a hyaluronic acid-chitosan degradable dressing. The method comprises the following steps: preparing a hyaluronic acid solution and chitosan solution, performing cross-linking reaction to the hyaluronic acid solution and chitosan solution, drying and forming to obtain the degradable dressing which is good in biocompatibility, and environment-friendly, high in water permeability and breathability due to a great amount of micropores inside, has obvious inhibition action to the majority of fungi, and can fade and eliminate scars and enable the healed and recovered wound not to have scars, and the degradable dressing is low in cost, short in production period, and wide in application range.

Description

technical field [0001] The invention discloses a method for preparing a hyaluronic acid-chitosan degradable dressing, which belongs to the field of preparation of biomedical dressings. technical background [0002] The skin is an important organ of the human body, a natural barrier and a bridge of communication between the body and the outside world. Loss of skin tissue due to burns, trauma, and skin ulcers can lead to wound infection. Currently, one effective method of dealing with skin wounds is the use of wound dressings. [0003] Traditional wound dressings include gauze, absorbent cotton, bandages, etc. However, from a medical point of view, these traditional wound dressings have limited clinical application because they do not have the properties of treating and repairing wounds, nor do they have antibacterial activity. Therefore, new medical dressings that can promote wound healing, have high antibacterial properties and are more convenient to use have gradually de...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J9/28C08J3/24C08L5/08A61L15/28A61L15/44
Inventor 王健
Owner 王剑
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