Ceftiofur hydrochloride breast injection for dairy cow in dry period and preparation method thereof
A technology for ceftiofur hydrochloride and breast injection, which is applied in the directions of medical preparations containing active ingredients, pharmaceutical formulations, and emulsion delivery, etc., can solve problems such as short action time, achieve slow drug release, simple production process, The effect of avoiding cross infection
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[0028] The ceftiofur hydrochloride breast injection provided by the present invention is a uniformly distributed preparation, and the specific preparation method includes the following steps:
[0029] A. The vegetable oil (such as neutral soybean oil) is filtered and heated to sterilize and then let cool;
[0030] B. Take an appropriate amount of pretreated vegetable oil and add 0.5-5g of glyceryl monostearate;
[0031] C. Heat at 60~80℃ for 15~30 minutes, wait for glyceryl monostearate to melt, stir evenly, cool to about 40℃, add 0.5~5g suspending agent (such as Span 80), 2.5~10g Ceftiofur hydrochloride (particle size 5-10μm), and then add vegetable oil to a total of 100ml;
[0032] D. Grind uniformly to prepare ceftiofur hydrochloride breast injection;
[0033] E. Put the medicine into the bolus injection tube, seal, sterilize, inspect and package.
[0034] The method for detecting the sedimentation particle size of the breast infusion in the following examples is: take 50ml of the te...
Example Embodiment
[0036] Example 1. Preparation of ceftiofur hydrochloride breast injection (dry milk period)
[0037]
[0038] The preparation method is as follows:
[0039] 1) Superfine ceftiofur hydrochloride sterile powder to obtain ceftiofur hydrochloride sterile powder with a particle size of 5-10μm;
[0040] 2) After filtering and heat sterilizing soybean oil (sterilized at 160°C for 2 hours), place it at room temperature for later use;
[0041] 3) Take an appropriate amount of pretreated soybean oil (40%-60% of the total amount of soybean oil), add glyceryl monostearate; heat and stir (warm at 60°C for 15 minutes), wait for glyceryl monostearate Melt the ester, stir well, cool to 40°C, add Span 80, ceftiofur hydrochloride, and soybean oil to the full amount;
[0042] 4) Grind evenly in a sterile colloid mill to prepare ceftiofur hydrochloride breast injection.
[0043] The properties of the obtained ceftiofur hydrochloride breast injection (dry milk period) are off-white to yellow oil suspension....
Example Embodiment
[0045] Example 2. Preparation of Ceftiofur Hydrochloride Breast Injection (Dry Milk Period)
[0046]
[0047] The preparation method is as follows:
[0048] 1) Superfine ceftiofur hydrochloride sterile powder to obtain ceftiofur hydrochloride sterile powder with a particle size of 5-10μm;
[0049] 2) After filtering and heating the soybean oil (sterilized at 150°C for 3 hours), place the soybean oil at room temperature for later use;
[0050] 3) Take an appropriate amount of pretreated soybean oil (40%-60% of the total amount of soybean oil), add glyceryl monostearate; heat and stir (warm at 80°C for 30 minutes), wait for glyceryl monostearate Melt the ester, stir well, cool to 40°C, add Span 80, ceftiofur hydrochloride, and soybean oil to the full amount;
[0051] 4) Grind evenly in a sterile colloid mill to prepare ceftiofur hydrochloride breast injection.
[0052] The properties of the obtained ceftiofur hydrochloride breast injection (dry milk period) are off-white to yellow oil sus...
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