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Ceftiofur hydrochloride breast injection for dairy cow in dry period and preparation method thereof

A technology for ceftiofur hydrochloride and breast injection, which is applied in the directions of medical preparations containing active ingredients, pharmaceutical formulations, and emulsion delivery, etc., can solve problems such as short action time, achieve slow drug release, simple production process, The effect of avoiding cross infection

Active Publication Date: 2015-04-29
FEED RESEARCH INSTITUTE CHINESE ACADEMY OF AGRICULTURAL SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The dosage forms of ceftiofur currently studied at home and abroad include dosage forms such as ceftiofur sodium powder for injection and ceftiofur sodium liposome. ~5 days

Method used

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  • Ceftiofur hydrochloride breast injection for dairy cow in dry period and preparation method thereof
  • Ceftiofur hydrochloride breast injection for dairy cow in dry period and preparation method thereof
  • Ceftiofur hydrochloride breast injection for dairy cow in dry period and preparation method thereof

Examples

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preparation example Construction

[0028] Ceftiofur hydrochloride breast injection provided by the invention is a uniformly distributed preparation, and the specific preparation method comprises the following steps:

[0029] A. Let the vegetable oil (such as neutral soybean oil) cool after filtering and heat sterilization;

[0030] B. Take an appropriate amount of pretreated vegetable oil and add 0.5 to 5 g of glyceryl monostearate;

[0031] C. Heat at 60-80°C for 15-30 minutes, wait for glycerol monostearate to melt, stir evenly, cool to about 40°C, add 0.5-5g suspending agent (such as Span 80), 2.5-10g ceftiofur hydrochloride (particle size 5-10μm), and then add vegetable oil to a total of 100ml;

[0032] D. Grind evenly to prepare ceftiofur hydrochloride breast injection;

[0033] E. Put the medicine into the injection tube, seal it, sterilize it, inspect it with light, and pack it.

[0034] In the following examples, the detection method of the sedimentation particle size of the breast injection is as fo...

Embodiment 1

[0036] Embodiment 1, preparation of ceftiofur hydrochloride breast injection (dry milk period)

[0037]

[0038] The preparation method is as follows:

[0039] 1) Ultrafine pulverization of ceftiofur hydrochloride sterile powder to obtain ceftiofur hydrochloride sterile fine powder with a particle size of 5-10 μm;

[0040] 2) After the soybean oil is filtered and heat sterilized (sterilized at 160°C for 2 hours), put it at room temperature for later use;

[0041] 3) Take an appropriate amount of pretreated soybean oil (40%-60% of the total amount of soybean oil), add glyceryl monostearate; heat and stir (heat at 60°C for 15 minutes), wait for glyceryl monostearate Melt the ester, stir evenly, cool to 40°C, then add Span 80, ceftiofur hydrochloride, and add soybean oil to the full amount;

[0042] 4) Grind evenly in a sterile colloid mill to prepare ceftiofur hydrochloride breast injection.

[0043] The obtained ceftiofur hydrochloride breast injection (dry milk stage) is...

Embodiment 2

[0045] Embodiment 2, preparation of ceftiofur hydrochloride breast injection (dry milk period)

[0046]

[0047] The preparation method is as follows:

[0048] 1) Ultrafine pulverization of ceftiofur hydrochloride sterile powder to obtain ceftiofur hydrochloride sterile fine powder with a particle size of 5-10 μm;

[0049] 2) After the soybean oil is filtered and heat sterilized (sterilized at 150°C for 3 hours), put it at room temperature for later use;

[0050] 3) Take an appropriate amount of pretreated soybean oil (40%-60% of the total amount of soybean oil), add glyceryl monostearate; heat and stir (heating at 80°C for 30 minutes), wait for glyceryl monostearate Melt the ester, stir evenly, cool to 40°C, then add Span 80, ceftiofur hydrochloride, and add soybean oil to the full amount;

[0051] 4) Grind evenly in a sterile colloid mill to prepare ceftiofur hydrochloride breast injection.

[0052] The obtained ceftiofur hydrochloride breast injection (dry milk stage)...

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Abstract

The invention discloses a ceftiofur hydrochloride breast injection for dairy cow in dry period and a preparation method thereof. The injection is prepared from the following raw and auxiliary materials: 2.5-10g of ceftiofur hydrochloride, 0.5-5g of glyceryl monostearate, 0.5-5g of a suspending agent and the balance of vegetable oil which is added until the total amount is 100ml. The preparation method comprises the following steps: mixing a proper amount of vegetable oil and glyceryl monostearate, heating and melting; then adding the suspending agent and ceftiofur hydrochloride, and adding the vegetable oil until total amount; and uniformly grinding to prepare the ceftiofur hydrochloride breast injection. The breast injection has the advantages of low drug release speed, high bioavailability and small irritation to local tissues; each lactation region of each dairy cow is independently administrated, so that cross infection is avoided; the injection is injected through breast and is convenient to use, so that animal stress reaction caused by parenteral administration can be avoided, and convenience is brought to clinical administration; the injection has a remarkable curative effect and extremely high popularization value.

Description

technical field [0001] The invention relates to a ceftiofur hydrochloride breast injection (dry milk period) and a preparation method thereof. Background technique [0002] Ceftiofur (CEF) is a third-generation cephalosporin antibiotic for animals. Ceftiofur has a wide antibacterial spectrum and strong antibacterial activity, and has strong antibacterial activity against Gram-positive bacteria, Gram-negative bacteria and some anaerobic bacteria; and has a stable β-lactam ring, which is effective against various Bacteria that can produce β-lactamase also have a good killing effect, and it is not easy to produce drug-resistant strains and cross-resistance. It is mainly used clinically for various infections caused by a variety of animal sensitive bacteria. Therefore, the application of ceftiofur in the treatment of livestock and poultry diseases is of great significance. [0003] The dosage forms of ceftiofur currently studied at home and abroad include dosage forms such as ...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K31/546A61P31/04A61P15/00
Inventor 李秀波刘义明赵蕾蕾闫星张道康
Owner FEED RESEARCH INSTITUTE CHINESE ACADEMY OF AGRICULTURAL SCIENCES
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