Ceftiofur hydrochloride breast injection for dairy cow in dry period and preparation method thereof

A technology for ceftiofur hydrochloride and breast injection, which is applied in the directions of medical preparations containing active ingredients, pharmaceutical formulations, and emulsion delivery, etc., can solve problems such as short action time, achieve slow drug release, simple production process, The effect of avoiding cross infection

Active Publication Date: 2015-04-29
FEED RESEARCH INSTITUTE CHINESE ACADEMY OF AGRICULTURAL SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The dosage forms of ceftiofur currently studied at home and abroad include dosage f

Method used

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  • Ceftiofur hydrochloride breast injection for dairy cow in dry period and preparation method thereof
  • Ceftiofur hydrochloride breast injection for dairy cow in dry period and preparation method thereof
  • Ceftiofur hydrochloride breast injection for dairy cow in dry period and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0028] The ceftiofur hydrochloride breast injection provided by the present invention is a uniformly distributed preparation, and the specific preparation method includes the following steps:

[0029] A. The vegetable oil (such as neutral soybean oil) is filtered and heated to sterilize and then let cool;

[0030] B. Take an appropriate amount of pretreated vegetable oil and add 0.5-5g of glyceryl monostearate;

[0031] C. Heat at 60~80℃ for 15~30 minutes, wait for glyceryl monostearate to melt, stir evenly, cool to about 40℃, add 0.5~5g suspending agent (such as Span 80), 2.5~10g Ceftiofur hydrochloride (particle size 5-10μm), and then add vegetable oil to a total of 100ml;

[0032] D. Grind uniformly to prepare ceftiofur hydrochloride breast injection;

[0033] E. Put the medicine into the bolus injection tube, seal, sterilize, inspect and package.

[0034] The method for detecting the sedimentation particle size of the breast infusion in the following examples is: take 50ml of the te...

Example Embodiment

[0036] Example 1. Preparation of ceftiofur hydrochloride breast injection (dry milk period)

[0037]

[0038] The preparation method is as follows:

[0039] 1) Superfine ceftiofur hydrochloride sterile powder to obtain ceftiofur hydrochloride sterile powder with a particle size of 5-10μm;

[0040] 2) After filtering and heat sterilizing soybean oil (sterilized at 160°C for 2 hours), place it at room temperature for later use;

[0041] 3) Take an appropriate amount of pretreated soybean oil (40%-60% of the total amount of soybean oil), add glyceryl monostearate; heat and stir (warm at 60°C for 15 minutes), wait for glyceryl monostearate Melt the ester, stir well, cool to 40°C, add Span 80, ceftiofur hydrochloride, and soybean oil to the full amount;

[0042] 4) Grind evenly in a sterile colloid mill to prepare ceftiofur hydrochloride breast injection.

[0043] The properties of the obtained ceftiofur hydrochloride breast injection (dry milk period) are off-white to yellow oil suspension....

Example Embodiment

[0045] Example 2. Preparation of Ceftiofur Hydrochloride Breast Injection (Dry Milk Period)

[0046]

[0047] The preparation method is as follows:

[0048] 1) Superfine ceftiofur hydrochloride sterile powder to obtain ceftiofur hydrochloride sterile powder with a particle size of 5-10μm;

[0049] 2) After filtering and heating the soybean oil (sterilized at 150°C for 3 hours), place the soybean oil at room temperature for later use;

[0050] 3) Take an appropriate amount of pretreated soybean oil (40%-60% of the total amount of soybean oil), add glyceryl monostearate; heat and stir (warm at 80°C for 30 minutes), wait for glyceryl monostearate Melt the ester, stir well, cool to 40°C, add Span 80, ceftiofur hydrochloride, and soybean oil to the full amount;

[0051] 4) Grind evenly in a sterile colloid mill to prepare ceftiofur hydrochloride breast injection.

[0052] The properties of the obtained ceftiofur hydrochloride breast injection (dry milk period) are off-white to yellow oil sus...

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Abstract

The invention discloses a ceftiofur hydrochloride breast injection for dairy cow in dry period and a preparation method thereof. The injection is prepared from the following raw and auxiliary materials: 2.5-10g of ceftiofur hydrochloride, 0.5-5g of glyceryl monostearate, 0.5-5g of a suspending agent and the balance of vegetable oil which is added until the total amount is 100ml. The preparation method comprises the following steps: mixing a proper amount of vegetable oil and glyceryl monostearate, heating and melting; then adding the suspending agent and ceftiofur hydrochloride, and adding the vegetable oil until total amount; and uniformly grinding to prepare the ceftiofur hydrochloride breast injection. The breast injection has the advantages of low drug release speed, high bioavailability and small irritation to local tissues; each lactation region of each dairy cow is independently administrated, so that cross infection is avoided; the injection is injected through breast and is convenient to use, so that animal stress reaction caused by parenteral administration can be avoided, and convenience is brought to clinical administration; the injection has a remarkable curative effect and extremely high popularization value.

Description

technical field [0001] The invention relates to a ceftiofur hydrochloride breast injection (dry milk period) and a preparation method thereof. Background technique [0002] Ceftiofur (CEF) is a third-generation cephalosporin antibiotic for animals. Ceftiofur has a wide antibacterial spectrum and strong antibacterial activity, and has strong antibacterial activity against Gram-positive bacteria, Gram-negative bacteria and some anaerobic bacteria; and has a stable β-lactam ring, which is effective against various Bacteria that can produce β-lactamase also have a good killing effect, and it is not easy to produce drug-resistant strains and cross-resistance. It is mainly used clinically for various infections caused by a variety of animal sensitive bacteria. Therefore, the application of ceftiofur in the treatment of livestock and poultry diseases is of great significance. [0003] The dosage forms of ceftiofur currently studied at home and abroad include dosage forms such as ...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K31/546A61P31/04A61P15/00
Inventor 李秀波刘义明赵蕾蕾闫星张道康
Owner FEED RESEARCH INSTITUTE CHINESE ACADEMY OF AGRICULTURAL SCIENCES
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