Compound motherwort herb mixture as well as preparation method and application thereof in treatment of gynecological diseases

A compound motherwort and motherwort technology, applied in sexual diseases, blood diseases, extracellular fluid diseases, etc., can solve the problems of complex compatibility and many types of traditional Chinese medicines, and achieve the effects of low technical content, good reproducibility and less solvent consumption

Inactive Publication Date: 2015-04-29
HENAN JIUSHI BIOLOGICAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007]① There are many kinds of traditional Chinese medicines in the prescription, and the compatibility is complicated;

Method used

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  • Compound motherwort herb mixture as well as preparation method and application thereof in treatment of gynecological diseases
  • Compound motherwort herb mixture as well as preparation method and application thereof in treatment of gynecological diseases
  • Compound motherwort herb mixture as well as preparation method and application thereof in treatment of gynecological diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Preparation method of compound motherwort mixture

[0055] 1) Extraction of active ingredients of Motherwort: Atmospheric pressure microwave-assisted extraction.

[0056] ① Crush the motherwort to 2～ 10 mm particle size, immerse in water for 2 hours, filter out the water, add cyclohexane-ethanol mixed solvent, and use atmospheric pressure microwave-assisted extraction (microwave wavelength 1mm-1m, frequency 300-300000MHZ). The extraction time was 15 min.

[0057] ② Separate and remove the medicinal residues to obtain an extract, and vacuum concentrate the extract below 60°C to an extract with a relative density of 1.21-1.25, then add invert sugar, mix well, and concentrate in vacuum to obtain a dry extract.

[0058] ③Using the airflow ultrafine pulverization method, the dried motherwort extract was pulverized, and the particle size ≤ 20 μm.

[0059] 2) Extraction of active components of Radix Astragali: Atmospheric pressure microwave-assisted extraction.

[0060]① ...

Embodiment 2

[0065] Experimental study on the comparison between microwave-assisted extraction technology and traditional extraction method

[0066] Microwave-assisted extraction technology has enhanced heat transfer and mass transfer on the basis of traditional extraction technology. The experiment shows that microwave extraction technology has high extraction efficiency, good reproducibility, less solvent consumption, simple equipment, easy operation, sufficient extraction and less pollution. Etc.

[0067] The application of microwave-assisted extraction technology to the active ingredients of Chinese herbal medicine and the extraction of active substances in plant cells is a new application field. The experimental results of microwave-assisted extraction technology compared with traditional extraction methods are shown in the table below.

[0068] Table 1. Comparison of microwave-assisted extraction technology and traditional extraction methods

[0069]

Embodiment 3

[0071] Dissolution Determination of Compound Motherwort Tablets

[0072] The particle size and surface area of ​​the drug are important factors affecting the dissolution rate of solid oral preparations. For the same weight of the drug, the smaller the particle size, the larger the surface area, the better the dissolution.

[0073] 1. For the dissolution test of compound motherwort tablets, two samples of different preparation methods of dry extract were selected:

[0074] 1) Atmospheric pressure microwave-assisted extraction to extract the active ingredients of motherwort and astragalus → vacuum concentration and vacuum drying to obtain dry extracts → use airflow ultrafine grinding method to crush the dry extracts of motherwort and dry extracts of astragalus into ultrafine powder, particle size ≤ 20 μm .

[0075] 2) Soak the chopped motherwort and astragalus in water → decoct and extract with water for 3 times to obtain the extract → vacuum concentrate, vacuum dry, crush and ...

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Abstract

The invention relates to a compound motherwort herb preparation as well as a preparation method and application thereof in treatment of gynecological diseases. The traditional Chinese medicine compound preparation contains active ingredients of motherwort herb and astragalus that are extracted by atmospheric pressure microwave-assisted extraction, wherein active substances of motherwort herb and astragalus are extracted by an atmospheric pressure microwave-assisted extraction method. According to the invention, the compound motherwort herb preparation has good effect on the treatment of gynecological diseases; the preparation method has the advantages of high extraction efficiency, full extraction, good reproducibility and less solvent consumption.

Description

technical field [0001] The invention relates to the field of Chinese herbal medicines, in particular to a compound motherwort mixture for treating gynecological diseases and a preparation method thereof, which can be used in gynecological diseases. Background technique [0002] Motherwort is a commonly used medicine in gynecology, which has the effects of promoting blood circulation, removing blood stasis, regulating menstruation, and eliminating water. [0003] Astragalus membranaceus is an important qi-invigorating medicine, which has the functions of invigorating qi and strengthening the surface, diuresis and swelling, detoxification and pus drainage, and muscle regeneration. [0004] There are many prescriptions for the combination of Motherwort and Astragalus. Motherwort and Astragalus are the pair of medicines, and the messenger refers to Motherwort as the main drug, and Astragalus as the supplement, with complementary effects to improve the efficacy of the main drug ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/533A61P15/00A61P7/04A61P31/04
CPCA61K9/0095A61K36/481A61K36/533A61K2300/00
Inventor 王效山时明昀
Owner HENAN JIUSHI BIOLOGICAL PHARMA
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