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Functional hollow mesoporous SiO2 nanometer composite material and preparation method thereof

A nano-composite material and hollow mesoporous technology, applied in the field of nano-composite material preparation, can solve the problems of poor dispersion, limited application, uneven particle size, etc., and achieve the effects of cheap raw materials and simple and easy production process.

Inactive Publication Date: 2015-05-06
HARBIN ENG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In the Journal of Progress in Biochemistry and Biophysics, 2013, Issue 40, Volume 10, pages 1014-1022, the article titled Research Progress of Multifunctional Nano-Drug Delivery System Based on Mesoporous Silica introduced mesoporous silica The preparation of the base-loaded drug system, but it has problems such as uneven particle size and poor dispersion, which limit its application in pharmaceutical technology

Method used

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  • Functional hollow mesoporous SiO2 nanometer composite material and preparation method thereof
  • Functional hollow mesoporous SiO2 nanometer composite material and preparation method thereof
  • Functional hollow mesoporous SiO2 nanometer composite material and preparation method thereof

Examples

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Embodiment 1

[0033] (1) Using hydrothermal synthesis of carbon sphere template agent. Accurately weigh 3g of glucose and dissolve it in 30mL of distilled water, stir rapidly to form a clear liquid, and then transfer them to 40mL sealable polytetrafluoroethylene reaction kettles, and then place the reaction kettles in an oven at 160°C for 5 hours at the same time, and the reaction is over Afterwards, the reactor was naturally cooled to room temperature to obtain black and purple products. Wash once with distilled water and absolute ethanol, and dry at 60°C for more than 4 hours.

[0034] (2) The phosphor precursor is coated on the surface of the carbon sphere template by co-precipitation method. The specific experimental steps are as follows: Accurately weigh 0.05 g of carbon spheres, and ultrasonically disperse them in 25 mL of distilled water. Then add 0.5mol / L of Y(NO 3 ) 3 , 0.1mol / L of Yb(NO 3 ) 3 and 0.05mol / L of Er(NO 3 ) 3 Each solution was 1840 μL, 200 μL and 200 μL, and th...

Embodiment 2

[0037] (1) Using hydrothermal synthesis of carbon sphere template agent. Accurately weigh 8g of glucose and dissolve it in 32mL of distilled water, stir quickly to form a clear liquid, then transfer them to 40mL sealable polytetrafluoroethylene reaction kettles, and then place the reaction kettles in an oven at 180°C for 8 hours at the same time, and the reaction is over Afterwards, the reactor was naturally cooled to room temperature to obtain black and purple products. Wash once with distilled water and absolute ethanol, and dry at 60°C for 10h.

[0038] (2) The phosphor precursor is coated on the surface of the carbon sphere template by co-precipitation method. The specific experimental steps are as follows: Accurately weigh 0.05 g of carbon spheres, and ultrasonically disperse them in 25 mL of distilled water. Then add 0.5mol / L of Y(NO 3 ) 3 , 0.1mol / L of Yb(NO 3 ) 3 and 0.05mol / L of Er(NO 3 ) 3 Each solution was 1840 μL, 200 μL and 200 μL, and then 4.0 g of urea w...

Embodiment 3

[0041] (1) Using hydrothermal synthesis of carbon sphere template agent. Accurately weigh 4g of glucose and dissolve it in 30mL of distilled water, stir quickly to form a clear liquid, then transfer them to 40mL sealable polytetrafluoroethylene reaction kettles, and then place the reaction kettles in an oven at 180°C for 5 hours at the same time, and the reaction is over Afterwards, the reactor was naturally cooled to room temperature to obtain black and purple products. Wash once with distilled water and absolute ethanol, and dry at 60°C for more than 4 hours.

[0042] (2) The phosphor precursor is coated on the surface of the carbon sphere template by co-precipitation method. The specific experimental steps are as follows: Accurately weigh 0.1 g of carbon spheres, and ultrasonically disperse them in 25 mL of distilled water. Then add 0.5mol / L of Y(NO 3 ) 3 , 0.1mol / L of Yb(NO 3 ) 3 and 0.05mol / L of Er(NO 3 ) 3 Each solution was 1840 μL, 200 μL and 200 μL, and then 3....

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Abstract

The invention provides a functional hollow mesoporous SiO2 nanometer composite material and a preparation method thereof. The preparation method of the invention is characterized by comprising the following steps: (1) preparing hollow ordered mesoporous nanometer materials of even particle diameters and fine dispersibilities by combined use of a co-precipitation method and a sol-gel method; (2) using CTAB as surfactant to enable formation of an ordered mesoporous silicon dioxide layer so that not only a larger surface area for leading in a large number of functional micellae is provided, but also larger pore diameters for absorbing and packaging biomolecules are provided; (3) synthesizing hollow ordered mesoporous structural nanometer composite materials of various sizes by altering reactant qualities and crystal growth time. The method of the invention has simple and easy experimentation and the experimental method is easy for manufacturing and promotion. According to the invention, the functional hollow mesoporous SiO2 nanometer composite material of the invention emits strong conversion fluorescence under 980nm stimulating luminesce so that the functional hollow mesoporous SiO2 nanometer composite material can be used in detections of drug slow-release process and curative effect.

Description

technical field [0001] The invention relates to a nanocomposite material, and also relates to a preparation method of the nanocomposite material. Specifically involving a Y 2 o 3 : Yb, Er coated hollow mesoporous SiO 2 Nanocomposites and methods for their preparation. Background technique [0002] Controlled drug release is one of the most important and attractive research fields, and the carrier is the most critical for controlling drug storage capacity and its release rate. In the last ten years, this research has been greatly improved. In the drug sustained-release system, a large number of organic systems have been used as new drug carriers for certain scientific experiments, such as micelles, liposomes and polymers. However, they all have various usage limitations, such as poor thermal and chemical stability, rapid breakdown in the immune system, and so on. [0003] Mesoporous materials with large surface area and ordered mesoporous structure are one of the most im...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/02A61K49/00C09K11/78C09K11/02
Inventor 杨飘萍杨丹盖世丽杨桂欣李磊杨金芝张强
Owner HARBIN ENG UNIV
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