MRI (magnetic resonance imaging)-guided targeted photo-thermal agent and preparation method of chemotherapeutic system of MRI-guided targeted photo-thermal agent

A technology of magnetic resonance imaging and photothermal agent, which can be applied to medical preparations without active ingredients, medical preparations containing active ingredients, preparations for in vivo experiments, etc., can solve problems such as easy sedimentation, and achieve simple steps, The effect of solving difficulties and high photothermal conversion efficiency

Inactive Publication Date: 2015-05-06
DONGHUA UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, MoS prepared by chemical exfoliation 2 Although the nanosheets can be stably dispersed in the aqueous phase, they are prone to sedimentation under physiological conditions

Method used

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  • MRI (magnetic resonance imaging)-guided targeted photo-thermal agent and preparation method of chemotherapeutic system of MRI-guided targeted photo-thermal agent
  • MRI (magnetic resonance imaging)-guided targeted photo-thermal agent and preparation method of chemotherapeutic system of MRI-guided targeted photo-thermal agent
  • MRI (magnetic resonance imaging)-guided targeted photo-thermal agent and preparation method of chemotherapeutic system of MRI-guided targeted photo-thermal agent

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Embodiment 1

[0030] (1) Under the protection of nitrogen, add 5mL of n-butyllithium n-hexane solution with a concentration of 1.6M to the solution containing 0.5gMoS 2 In the powder reaction tube, stir at 800rpm at room temperature for 2 days. After the reaction, use a Buchner funnel to filter, wash the filter residue with 100mL of n-hexane to remove excess n-butyllithium, and then wash with 300mL deionized water. A certain amount of deionized water was washed into the beaker, and MoS was obtained after ultrasonic dispersion for 1 hour. 2 Nanosheets;

[0031] (2) After measuring the concentration of the MoS2 aqueous solution by inductively coupled plasma atomic emission spectrometry, take an aqueous solution containing 100 mg of MoS2 nanosheets, add 0.2 g of PEI with a molecular weight of 25,000 to it, stir at room temperature for 1 h, and then put it into 60 ° C oil The bath was refluxed for 24 hours to obtain PEI-modified MoS 2 Nanosheets;

[0032] (3) Take 0.3g FeCl 2 4H 2 O was di...

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Abstract

The invention relates to a MRI (magnetic resonance imaging)-guided targeted photo-thermal agent and a preparation method of a chemotherapeutic system of the MRI-guided targeted photo-thermal agent. The method comprises the following steps: by using a hydrothermal method, preparing superparamagnetic ferroferric oxide nano-particles on PEI modified MoS2 in an in-situ preparation mode, thus obtaining a PEI modified MoS2 nano composite; preparing polyethylene glycol coupled targeting molecules by using EDC chemical; by using an EDC chemical, connecting polyethylene glycol with the targeting molecules to the PEI modified MoS2 nano composite in a covalent linkage mode; and through physical adsorption, loading a micromolecular anti-tumor drug on a carrier. The method disclosed by the invention is easy to operate and simple in step, and the prepared multi-functional MoS2 nano composite is good in biological compatibility, can be specifically gathered at tumor sites so as to effectively kill tumor cells, and can effectively integrate early diagnosis and late treatment so as to realize the integration of diagnosis and treatment of cancer treatment.

Description

technical field [0001] The invention belongs to the field of preparation of targeted photothermal agents, in particular to a preparation method of a magnetic resonance imaging-guided targeted photothermal agent and a chemotherapy system thereof. Background technique [0002] Photothermal therapy refers to the use of absorbers with photothermal conversion function to convert near-infrared light into heat energy, which can increase the local temperature and cause malignant cell necrosis. As an emerging cancer treatment technology in recent years, photothermal therapy has many incomparable advantages over traditional treatment methods such as chemotherapy and radiotherapy, such as less invasiveness, less side effects, fast and convenient treatment, etc. Although many inorganic photothermal materials have been developed one after another, their defects such as difficult modification, poor biocompatibility and chemical stability greatly limit their further applications in the fie...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/12A61K41/00A61K47/34A61P35/00
Inventor 何创龙陈良冯炜周小军
Owner DONGHUA UNIV
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