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Application of grateloupia livida extract in preparation of medicines or health foods with memory improving function

A tongue-shaped centipede algae, memory-improving technology, applied in the application of medicines or health food for improving learning and memory functions, in the field of preparation of centipede algae extract, can solve rare problems, achieve clear mechanism of action, high safety , high safety effect

Active Publication Date: 2015-05-20
INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Although the resources of Centipede lingulae are abundant, the sources are wide, and there are certain biological activities, there are still few studies on its application at home and abroad, especially the effect of extracts of Centipede lingulae on improving learning and memory functions is still unknown. is blank

Method used

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  • Application of grateloupia livida extract in preparation of medicines or health foods with memory improving function
  • Application of grateloupia livida extract in preparation of medicines or health foods with memory improving function
  • Application of grateloupia livida extract in preparation of medicines or health foods with memory improving function

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] The preparation of embodiment 1 tongue-shaped centipede algae extract

[0018] Add 10 times the mass of 0.01mol / L dilute hydrochloric acid to soak 100g of dried centipede algae for 30 minutes, then pour out the dilute acid solution and wash it with tap water until the cleaning solution is neutral, then add 3L distilled water and extract at 100°C 3 hours. 300-mesh silk filter to remove the algae residue, and the filtrate is filtered with diatomaceous earth. The resulting filtrate was concentrated, and then the concentrate was spray-dried to obtain 28 g of an extract of Centipede lingulae.

Embodiment 2

[0019] The preparation of embodiment 2 long leaf centipede algae (Grateloupia filicina) extract

[0020] Soak 100g of dried Centipede algae with 10 times the mass of 0.01mol / L dilute acetic acid for 30min, then pour out the dilute acid solution and wash it with tap water until the cleaning solution is neutral, then add 3L of distilled water and extract at 100°C 3 hours. 300-mesh sieve was filtered to remove the algae residue, the filtrate was centrifuged at 4000 rpm, the supernatant was collected and concentrated, and then the concentrate was spray-dried to obtain 32 g of Centipede longifolia extract.

Embodiment 3

[0021] Example 3: Improving Memory Function of Centipede Tongue Algae Extract

[0022] In the present invention, the improvement of the memory function of the centipede algae extract is deeply studied by taking the behavioral science and the acetylcholinesterase and acetylcholine transferase in the brain as indicators.

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Abstract

The invention relates to application of a grateloupia livida extract in preparation of medicines or health foods with a memory improving function. Solid powder is obtained by the following steps: dilute acid soaking treatment on grateloupia livida, hot water extraction, solid-liquid separation, concentration, spray drying and the like. The grateloupia livida extract has the effects of inhibiting the activity of acetylcholin esterase, improving the activity of choline acetyl transferase, improving the content of acetyl choline in a central nervous system, and improving the memory.

Description

technical field [0001] The invention belongs to the technical field of comprehensive development and utilization of marine biological resources, and in particular relates to a preparation method of centipede algae extract and its application in medicine or health food for improving learning and memory functions. Background technique [0002] With the improvement of living conditions and the development of science and technology, people's demand for health food to improve memory function and prevent and treat dementia is becoming more and more vigorous. After inquiry, among the 27 types of health food stipulated in my country, there are 90 kinds of health food with auxiliary memory function approved by the State Food and Drug Administration after December 12, 2003, accounting for 5293 kinds of domestic health food. The proportion is very small, and this type of product has great development prospects. [0003] Studies suggest that the central cholinergic system is closely rel...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/02A23L1/29A23L1/337A61P25/00A23L17/60A23L33/00
Inventor 张全斌张文静李晓红金维华段德麟
Owner INST OF OCEANOLOGY - CHINESE ACAD OF SCI