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Traditional Chinese medicine composition for treating diabetic peripheral neuropathy and preparation method thereof

A technology for peripheral neuropathy and composition, which is applied in drug combinations, nervous system diseases, and pharmaceutical formulations, etc. It can solve the problems of diabetic peripheral neuropathy, such as the general effect of diabetic peripheral neuropathy, the acceleration of motor nerve conduction speed, and the influence of extensive clinical promotion, so as to achieve therapeutic effects. Good, low dosage, and the effect of saving drug resources

Active Publication Date: 2015-05-20
XINJIANG UYGUR AUTONOMOUS REGION CHINESE MEDICINE HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned preparations have general effects in the treatment of diabetic peripheral neuropathy, and the cure rate is not too high.
Pharmacodynamic experiments showed that the effect on accelerating the conduction velocity of peripheral motor nerves in rats, reducing the low-shear reduced viscosity of whole blood, and improving damaged nerve fibers was not optimal, and the effect on the relative expression of MnSOD and GPx1 genes was relatively weak. Affect its wide clinical promotion

Method used

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  • Traditional Chinese medicine composition for treating diabetic peripheral neuropathy and preparation method thereof
  • Traditional Chinese medicine composition for treating diabetic peripheral neuropathy and preparation method thereof
  • Traditional Chinese medicine composition for treating diabetic peripheral neuropathy and preparation method thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0015] Example 1 Chinese medicine composition of the present invention and preparation method thereof

[0016] [Prescription]: Astragalus 400g, Salvia miltiorrhiza 400g, Polygonatum 400g, Chickpea 350g, Cicada slough 350g.

[0017] [Preparation method] the above five flavors, cicada slough are crushed into fine powder, and set aside; Salvia miltiorrhiza is crushed into the coarsest powder, add 8 times by weight of ethanol aqueous solution with a volume concentration of 80% ethanol and reflux extraction twice, each time for 2.5 hours, filter, Combine the filtrates, recover ethanol under reduced pressure and concentrate to a clear paste with a relative density of 1.13 (measured at 60°C), i.e. Danshenol extraction paste, for later use; Danshenol extract dregs are mixed with Astragalus, Polygonatum, and Chickpea, and added 8 times The water decoction of parts by weight is decocted 3 times, each time for 2.5 hours, filtered, combined decoction, and concentrated under reduced press...

Embodiment 2

[0018] Example 2 Chinese medicine composition of the present invention and preparation method thereof

[0019] [Prescription]: Astragalus 400g, Salvia miltiorrhiza 400g, Polygonatum 400g, Chickpea 350g, Cicada slough 350g.

[0020] [Preparation method] the above five flavors, cicada slough are crushed into fine powder, and set aside; Salvia miltiorrhiza is crushed into the coarsest powder, add 8 times by weight of ethanol aqueous solution with a volume concentration of 80% ethanol and reflux extraction twice, each time for 2.5 hours, filter, Combine the filtrates, recover ethanol under reduced pressure and concentrate to a clear paste with a relative density of 1.13 (measured at 60°C), i.e. Danshenol extraction paste, for later use; Danshenol extract dregs are mixed with Astragalus, Polygonatum, and Chickpea, and added 8 times The water decoction of parts by weight is decocted 3 times, each time for 2.5 hours, filtered, combined decoction, and concentrated under reduced pres...

Embodiment 3

[0021] Example 3 Chinese medicine composition of the present invention and preparation method thereof

[0022] [Prescription]: Astragalus 400g, Salvia miltiorrhiza 400g, Polygonatum 400g, Chickpea 350g, Cicada slough 350g.

[0023] [Preparation method] the above five flavors, cicada slough are crushed into fine powder, and set aside; Salvia miltiorrhiza is crushed into the coarsest powder, add 8 times by weight of ethanol aqueous solution with a volume concentration of 80% ethanol and reflux extraction twice, each time for 2.5 hours, filter, Combine the filtrates, recover ethanol under reduced pressure and concentrate to a clear paste with a relative density of 1.13 (measured at 60°C), i.e. Danshenol extraction paste, for later use; Danshenol extract dregs are mixed with Astragalus, Polygonatum, and Chickpea, and added 8 times The water decoction of parts by weight is decocted 3 times, each time for 2.5 hours, filtered, combined decoction, and concentrated under reduced pres...

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Abstract

The invention relates to a traditional Chinese medicine composition for treating diabetic peripheral neuropathy and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition mainly comprises the following raw medicinal materials in parts by weight: 300-700 parts of astragalus membranaceus, 300-700 parts of danshen, 300-700 parts of siberian solomonseal rhizomes, 300-600 parts of chickpeas and 300-600 parts of cicada sloughs. Compared with an existing traditional Chinese medicine composition for treating diabetic peripheral neuropathy, the traditional Chinese medicine composition has a good treatment effect, is stable in preparation and has no any toxic or side effect.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating diabetic peripheral neuropathy and a preparation method thereof. Background technique [0002] Diabetes is a common disease, frequently-occurring disease, and a major disease that endangers human health. Diabetic peripheral neuropathy is a common chronic complication of diabetes and one of the important causes of disability and death in diabetic patients. Diabetic peripheral neuropathy is developed on the basis of diabetes. It is based on deficiency of viscera and yin, deficiency of both qi and yin, and abnormal distribution of body fluid. Pain, numbness, etc. The onset of diabetic peripheral neuropathy is the result of the joint action of many factors. Hyperglycemia and hyperlipidemia are a basic factor of diabetic peripheral neuropathy. The severity of neuropathy is closely related to blood sugar control. ...

Claims

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Application Information

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IPC IPC(8): A61K36/8969A61P3/10A61P25/02A61K35/64
Inventor 胡晓灵刘涛
Owner XINJIANG UYGUR AUTONOMOUS REGION CHINESE MEDICINE HOSPITAL
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