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Capsule skin of chewable soft capsule with antibacterial property and soft capsule prepared therefrom

A technology of capsule skin and soft capsule, which is applied in the direction of medical preparations of non-active ingredients, capsule delivery, food forming, etc., to achieve the effect of full and three-dimensional taste, pleasant taste, and prolonged storage

Active Publication Date: 2018-01-23
安徽墨药集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In the prior art, there are no related reports that chitosan is used in the preparation of chewable soft capsules to improve the antibacterial properties of the capsules, better protect the contents of the soft capsules, and prolong the storage, quality assurance and shelf life of the contents of the soft capsules

Method used

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  • Capsule skin of chewable soft capsule with antibacterial property and soft capsule prepared therefrom
  • Capsule skin of chewable soft capsule with antibacterial property and soft capsule prepared therefrom

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1 The capsule skin of the chewable soft capsule with antibacterial properties is prepared from the following mass ratio components: animal gelatin with a freezing strength of 150: glycerin: purified water: sweetener (crystalline fructose, sucralose): natural flavoring Agent (sweet orange powder): chitosan (degree of deacetylation≥80%)=30:15:30:10:1.5:0.3; the preparation method is as follows:

[0029] (1) Dissolve the natural flavoring agent in purified water with an amount of 15% of purified water, mix well, heat to 30~32°C, add chitosan, and continue stirring for 10 minutes to obtain a chitosan mixed solution. Ultrasonic treatment of 20mim under ultrasonic frequency of 50KHz, cooling to 10°C;

[0030] (2) Set the jacket temperature of the chemical tank to 65°C to heat the chemical tank, add glycerin, remaining purified water, crystalline fructose, and sucralose to the chemical tank, stir for 25 minutes until the materials are evenly dissolved, and add chitosan...

Embodiment 2

[0034] Example 2 The capsule skin of chewable soft capsules with antibacterial properties is prepared from the following mass ratio components: animal gelatin with a freezing strength of 200: glycerin: purified water: xylitol: natural flavoring agent (strawberry powder): chitosan Sugar (deacetylation degree ≥ 80%) = 25:20:30:12:2.5:1.2; the preparation method is as follows:

[0035] (1) Dissolve the natural flavoring agent in purified water with an amount of 16% purified water, mix evenly, heat to 30~32°C, add chitosan, and continue stirring for 15 minutes to obtain a chitosan mixed solution. Ultrasonic treatment with frequency of 40KHz for 22mim, cooled to 15°C;

[0036] (2) Set the jacket temperature of the chemical tank to 65°C to heat the chemical tank, add glycerin, the remaining purified water, and xylitol into the chemical tank, stir for 20 minutes until the materials are evenly dissolved, add the chitosan solution after ultrasound, Continue to stir for 10 minutes;

...

Embodiment 3

[0040] Example 3 Prepare antibacterial chewable soft capsules from the following mass ratio components: animal gelatin with a freezing strength of 180: glycerin: purified water: steviol glycosides: natural flavoring agent (blueberry powder): chitosan (deacetylated degree ≥ 80%)=35:18:28:10:1:0.1; the preparation method is as follows:

[0041] (1) Dissolve the natural flavoring agent in purified water with an amount of 20% purified water, mix evenly, heat to 30~32°C, add chitosan, and continue stirring for 15 minutes to obtain a chitosan mixed solution. Ultrasonic treatment with frequency of 60KHz for 15mim, cooling to 12°C;

[0042] (2) Set the jacket temperature of the chemical tank to 65°C to heat the chemical tank, add glycerin, remaining purified water, and steviol glycosides to the chemical tank, stir for 25 minutes until the materials are evenly dissolved, add the chitosan solution after ultrasonication, and continue Stir for 5 minutes;

[0043] (3) When the temperature ...

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Abstract

The invention discloses an antibacterial capsule shell of a chewable soft capsule and a soft capsule prepared from the antibacterial capsule shell. The capsule shell disclosed by the invention is prepared from gelatin, glycerinum, purified water, a sweetening agent, a natural flavouring agent and chitosan with the mass ratio of (25-35):(10-20):(25-35):(5-15):(1-2.5):(0.1-2.0). The preparation process comprises the following steps of: dissolving the natural flavouring agent in a part of purified water, adding chitosan, dissolving, carrying out ultrasonic treatment, mixing the ultrasonic-treated chitosan solution with other components, dissolving, and melting glue to obtain glue solution so as to obtain the capsule shell from the glue solution. The capsule shell has good antibacterial property and stability and is capable of protecting the contents of the soft capsule better and prolonging the storage period, the guarantee period and the shelf life of the contents of the soft capsule; the capsule shell prepared by the technical scheme disclosed by the invention and the chewable soft capsule prepared from liquid or semi-solid drugs, foods or health-care foods have better flexibility, chewiness and mouth feel; after the soft capsule is broken, the capsule shell can be dissolved or dispersed rapidly; and thus, the capsule shell is easy to swallow.

Description

technical field [0001] The invention relates to a capsule skin of a chewable soft capsule, in particular to a capsule skin of a soft capsule with antibacterial properties and a soft capsule prepared therefrom, belonging to the technical field of medicine, food, health food or pharmacy. Background technique [0002] After ordinary soft capsules are broken, the rubber skin cannot be quickly dissolved or dispersed, and it is not easy to be swallowed. It will leave elastic bodies like chewing gum in the mouth, which will affect the acceptance of consumers. Chewable soft capsules are a breakthrough in traditional soft capsules. In the way of swallowing, its chewable characteristics make health food more delicious. [0003] In the prior art, the chewability of chewable soft capsules is not ideal, and the stability is relatively poor, mainly by adding plasticizers, polymer modifiers and water to the capsule skin formulation of chewable soft capsules to increase its stability. Chew...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K47/36A61K47/46A23P10/30A23L33/00
Inventor 梅丹陈文俊
Owner 安徽墨药集团有限公司
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