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Coptis Ejiao composition for treating chronic fatigue syndrome and application thereof

A technology of chronic fatigue and composition, which is applied in the field of Coptis donkey-hide gelatin composition for the treatment of chronic fatigue syndrome, can solve the problems affecting the evaluation of CFS curative effect, the confusion of TCM classification, etc., and achieve safe clinical use, obvious effect and remarkable effect Effect

Active Publication Date: 2018-04-20
SHAN DONG DONG E E JIAO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the TCM classification of CFS syndromes is mostly based on the experience of doctors, and the TCM classification is relatively chaotic, which affects the evaluation of the efficacy of TCM in the treatment of CFS.
At present, there is no Chinese medicine preparation for the treatment of chronic fatigue syndrome with definite curative effect on the market.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1: the preparation of capsule

[0032] (1) Weigh each raw material according to the following weight: Coptidis 800g, Ejiao 900g, Radix Paeoniae Alba 600g, Scutellaria baicalensis 300g, Suanzaoren 600g, Cinnamon 200g, Albizia Julibrissin 600g;

[0033] (2) Extract the volatile oil from cinnamon, wrap the volatile oil and crush it, set aside;

[0034] (3) Extract the cinnamon dregs after extracting the volatile oil with water for two times, add 2 times the weight of water for the first time, decoct for 3 hours, add 4 times the weight of water for the second time, and decoct for 1 hour; Combine the boiled liquids, filter, and concentrate the filtrate to a clear paste with a relative density of 1.30-1.35 (55°C); combine the clear paste twice, spray dry, and set aside;

[0035] (4) Extract Coptidis Rhizoma, Radix Paeoniae Alba and Jujube Semen with 85% ethanol, concentrate the ethanol in the extract, spray dry it, and set aside;

[0036] (5) Grind donkey-hide ge...

Embodiment 2

[0037] Embodiment 2: the preparation of capsule

[0038] Prescription Composition:

[0039] Coptidis 280g Donkey-hide gelatin 315g White peony 210g Scutellaria baicalensis 105g

[0040] Suanzaoren (stir-fried) 210g cinnamon 70g Albizia bark 210g

[0041] Preparation Process:

[0042] (1) Coptis chinensis, Radix Paeoniae Alba, and Suanzaoren plus 70% ethanol were extracted 6 times for 3 times, each time for 1.5 hours, filtered, the filtrate recovered ethanol, concentrated to a relative density of 1.08-1.10 (60°C), and spray-dried to obtain fine powder spare;

[0043] (2) Add 12 times the amount of water to cinnamon, soak for 3 hours, extract the volatile oil for 3.5 hours, store the volatile oil and water extract for later use, and save the dregs for later use; add 10 times the amount of β-cyclodextrin to the cinnamon volatile oil and then add β-cyclodextrin Mix 20% ethanol with 3 times the amount of dextrin, grind it with a colloid mill for 15 minutes, refrigerate for 24 h...

Embodiment 3

[0046] Embodiment 3: the preparation of powder

[0047] Weigh the raw materials according to the following weights: Coptidis 600g, donkey-hide gelatin 700g, white peony root 400g, scutellaria baicalensis 100g, jujube seed 400g, cinnamon 50g, acacia bark 400g; crush the above-mentioned raw materials and pass through a 80-mesh sieve to obtain the product.

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Abstract

The invention discloses a Coptis donkey-hide gelatin composition for treating chronic fatigue syndrome and an application thereof, belonging to the field of traditional Chinese medicines. The traditional Chinese medicine composition of the invention comprises the following raw materials: Coptidis Rhizoma, Ejiao, Radix Paeoniae Alba, Radix Scutellariae, Jujube Seed, Cinnamon and Cortex Albiziae. The prescription of the present invention has the functions of nourishing yin and moistening dryness, clearing heat and detoxification, promoting blood circulation and removing blood stasis, and has obvious effects in treating chronic fatigue syndrome, with a cure rate of 67.2% and a total effective rate of 96.9%. It has the characteristics of good curative effect, short course of treatment, and no side effects. . The formula and the preparation method of the invention are unique, and the effect on the prevention and treatment of chronic fatigue syndrome is remarkable.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a Coptis donkey-hide gelatin composition for treating chronic fatigue syndrome and an application thereof. Background technique [0002] Chronic fatigue syndrome (CFS) is a group of syndromes characterized by persistent or recurrent fatigue, accompanied by a variety of neurological and psychiatric symptoms, but without organic and psychiatric diseases. The U.S. Centers for Disease Control and Prevention established this disease in the late 1980s, and there are many patients in Japan, European and American economically developed countries, and cities such as Hong Kong. The main symptom of Chronic Fatigue Syndrome is long-term extreme fatigue, including mental fatigue and physical fatigue. Patients often feel sleep deprivation. Even long-term bed rest fails to relieve fatigue, physical strength will continue to decline, and the amount of exercise i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/725A61P39/00A61K35/36
Inventor 周祥山田守生张淹王春艳李民李士栋
Owner SHAN DONG DONG E E JIAO
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