Method for preparing high-purity doramectin

A doramectin, high-purity technology, applied in the field of doramectin preparation, can solve the problems of increased operation steps and production costs, low purity, environmental pollution, etc., to reduce process operations and equipment requirements, improve Product quality, the effect of reducing production costs
CN104693254AActive Publication Date: 2015-06-10CHONGQING QIANTAI BIOLOGICAL MEDICINE +1
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
CHONGQING QIANTAI BIOLOGICAL MEDICINE
Publication Date
2015-06-10

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Abstract

The invention discloses a method for preparing a high-purity doramectin. The method comprises the steps of extracting the fermenting solution, condensing, pulping, crystallizing and the like to obtain the high-purity doramectin. The doramectin can be extracted by adopting a pulping and crystallizing process, and the method has the advantages of simple and easy process, high yield, high product quality, low production cost, and suitability for industrial production.
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Description

technical field

[0001] The invention belongs to the technical field of industrial microorganisms, and in particular relates to a preparation method of high-purity doramectin. Background technique

[0002] Parasitic diseases are one of the most serious zoonotic diseases at present, seriously affecting the healthy development of animal husbandry and the safety of human life. Among the many anti-parasitic drugs in animals, avermectins are currently the most excellent broad-spectrum and high-efficiency veterinary anti-parasitic drugs. Ivermectin, Doramectin and Eprinomectin. Among them, doramectin is a new generation of macrolide antiparasitic drug developed by Pfizer of the United States in the 1990s, and is considered to be one of the best drugs among avermectins. Doramectin is produced by genetically recombined Streptomyces avermitilis ( Streptomyces avermitilis ) The new strain is a sixteen-membered macrolide semi-synthetic antibiotic formed by fermenting the precursor su...

Claims

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