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Acellular pertussis combined vaccine and preparation method thereof

A combined vaccine and cell-free technology, applied in the direction of antibacterial drugs, bacterial antigen components, etc., can solve problems that are not conducive to product quality stability, and achieve the effects of reducing vaccination costs, simple operation, and good social and economic benefits

Inactive Publication Date: 2015-06-17
CHENGDU OLYMVAX BIOPHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Shanghai Preventive Medicine, 2006, 18(1): 3~5), so the co-purification process is not conducive to the stable quality of the product

Method used

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  • Acellular pertussis combined vaccine and preparation method thereof
  • Acellular pertussis combined vaccine and preparation method thereof
  • Acellular pertussis combined vaccine and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1: a kind of cell-free pertussis combination vaccine, it is made up of the raw material of following components:

[0025]

Embodiment 2

[0026] Embodiment 2: a kind of cell-free pertussis combination vaccine, it is made up of the raw material of following components:

[0027]

Embodiment 3

[0028] Embodiment 3: a kind of cell-free pertussis combination vaccine, it is made up of the raw material of following components:

[0029]

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PUM

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Abstract

The invention discloses an acellular pertussis combined vaccine and a preparation method thereof and belongs to the technical field of production and preparation of vaccines. The acellular pertussis combined vaccine is prepared from the following raw material components: 5-40Mu g of pertussis toxin, 5-40Mu g of filamentous hemagglutinin, 2-10Mu g of pertussis adhesin, 10-25lf of diphtheria toxoid, 4-10lf of tetanus toxoid, 1.0-2.0mg / ml of aluminium hydroxide and 7.5-9.5g / L of sodium chloride. The preparation method of the acellular pertussis combined vaccine comprises the following steps: preparing monovalent vaccine original fluids, mixing and diluting. The acellular pertussis combined vaccine is clear and definite in ingredients, quality control can be easily realized, the side effect is small, and the safety is high; and the preparation method of the acellular pertussis combined vaccine is simple to operate, convenient in preparation and low in cost, so that the acellular pertussis combined vaccine is applicable to industrial mass production.

Description

technical field [0001] The invention belongs to the technical field of vaccine production and preparation, and in particular relates to a cell-free pertussis combined vaccine and a preparation method thereof. Background technique [0002] Pertussis, diphtheria, tetanus and other diseases are widespread in our country and cause serious harm. Timely vaccination is an effective preventive and protective measure. The vaccines currently used in the planned immunization in my country to prevent pertussis, diphtheria and tetanus include whole-cell DPT vaccine (DTwP) and acellular DPT vaccine (DTaP). The difference between the two is that the pertussis in the combined vaccine is different, that is, whole-cell pertussis and acellular pertussis. [0003] As the name implies, whole-cell pertussis is inactivated with an appropriate inactivator and then used as a vaccine for immunization directly with an adjuvant. As the first vaccine included in WHO's Expanded Immunization Program (EP...

Claims

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Application Information

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IPC IPC(8): A61K39/116A61K39/10A61K39/08A61K39/05A61P31/04
CPCA61K39/05A61K39/08A61K39/116
Inventor 陈道远李洪光吴强陈元芬马礼耕韩炼罗力心
Owner CHENGDU OLYMVAX BIOPHARM
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