Preparation of flaky cross-linked sodium hyaluronate hydrogel

A technology of cross-linking hyaluronic acid and sodium hyaluronate, which is applied in the field of medical biomaterials, can solve the problems of insufficient strength and toughness of sodium hyaluronate hydrogel, and achieve an effect that is beneficial to growth

Active Publication Date: 2015-06-24
BEIJING MENGBORUN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The purpose of the present invention is to solve the problem of insufficient strength and toughness of sodium hyaluronate hydrogel, and provide a cross-linked h

Method used

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  • Preparation of flaky cross-linked sodium hyaluronate hydrogel
  • Preparation of flaky cross-linked sodium hyaluronate hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Take 10 grams of sodium hyaluronate (molecular weight is about 3×10 6 ) In a 250ml beaker, 500 μl of 1,4 butanediol diglycidyl ether (BDDE) was dissolved in a 250ml beaker of 40ml 1% sodium hydroxide, and the lye mixed with BDDE was poured into the hyaluronic acid Sodium in a beaker. After mixing thoroughly, enter the figure 2 machine, extruding the gel into strips on the grid. The thickness of the gel is 1mm, and the flake gel is placed flat on the bottom of the flat-bottomed stainless steel tray, in a water bath at 50°C, for 2 hours, and taken out and rolled four times during this process. Remove the tray and rinse it under pure running water for 2 hours. After draining, place it in a vacuum drying oven at 50°C for 3 hours. Phosphate-buffered saline (0.276g Na in 1000ml water 2 HPO 4 .2H 2 O; 0.0395 g NaH 2 PO 4 ..4H 2 O,; 8.476N a CL, pH value 7.3) soaked for 3 hours, the swelling degree reached 50%. Cut the hydrogel into a 30mm×50mm rectangle and plasti...

Embodiment 2

[0031] Take 10 grams of sodium hyaluronate (molecular weight is about 3×10 6 ) In a 250ml beaker, 1000 μl of 1,2,7,8 octane was dissolved in 40ml of 1% sodium hydroxide in a 250ml beaker, and the lye mixed with BDDE was poured into the beaker with sodium hyaluronate. The rest are the same as above. This product is more elastic and less viscous.

Embodiment 3

[0033] Take 10 grams of sodium hyaluronate (molecular weight is about 3×10 6 ) In a 250ml beaker, 500 μl of 1,2,7,8 octane was dissolved in 40ml of 1% sodium hydroxide in a 250ml beaker, and the lye mixed with BDDE was poured into the beaker with sodium hyaluronate. The rest are the same as above. This product is less elastic and more viscous.

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Abstract

The invention provides a cross-linked sodium hyaluronate hydrogel material, which is good in tissue compatibility, high in strength, good in breathability and high in exudates absorbing capacity, and has certain transparency. According to the cross-linked sodium hyaluronate hydrogel material, with a sparse fiber mesh structure as a framework, the cross-linked sodium hyaluronate gel is combined with the sparse fiber mesh structure, so as to form hydrogel with a similar armored concrete structure; the hydrogel is formed by crosslinking the sodium hyaluronate and combining with phosphate buffer saline; and the phosphate buffer saline contains a bacteriostatic agent. According to the hydrogel with the structure, the characteristics of the sodium hyaluronate hydrogel are kept; and the strength and the toughness of the sodium hyaluronate hydrogel are increased.

Description

technical field [0001] The invention belongs to the field of medical biomaterials, and in particular relates to a preparation method of sheet-shaped cross-linked sodium hyaluronate hydrogel. Background technique [0002] Hydrogel is a three-dimensional network structure composed of hydrophilic natural or synthetic polymers, and abundant water molecules are scattered in the network. The hydrogel itself contains a certain amount of water, and at the same time, due to the presence of hydrophilic residues, it can further absorb water until it is saturated with water. [0003] The biological properties of hydrogel are close to those of loose connective tissue; it has shown application prospects in the fields of cell growth scaffolds, medical electrodes, biosensors, drug sustained release carriers, contact lenses, stem cell storage, tissue filling, wound healing, etc., especially The role of hydrogels in wound healing has attracted great attention from scholars. [0004] In 1962...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/44A61L15/46A61L15/60
CPCA61L15/28A61L15/44A61L15/46A61L15/60
Inventor 蒙一纯
Owner BEIJING MENGBORUN BIOTECH
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