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Production method of sultopride hydrochloride

A technology of sultapride hydrochloride and a production method, which is applied in the field of pharmaceutical preparation, can solve the problems of complex production and high manufacturing cost, and achieve the effects of low production cost and simple manufacturing process

Inactive Publication Date: 2015-07-01
蒋学京
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because currently in the process of producing sultopride hydrochloride, the manufacturing cost is high and the production is complicated

Method used

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Embodiment Construction

[0006] The present invention will now be described in further detail.

[0007] The method for producing sultopride hydrochloride of the present invention, the specific steps are as follows: a. 17.22g of N-ethyl-α-aminomethylpyrrolidine is dissolved in 360mL of pyridine, and 3.51g of phosphorus trichloride is added to the solution at room temperature. After stirring for 1 h in 40 mL of pyridine solution, add 10 g of 2-methoxy-5-ethylsulfonyl benzoic acid and heat to reflux for 4.5 h; b. Cool, concentrate under reduced pressure, and dissolve the residue in 200 mL of 20% hydrogen Sodium oxide solution was extracted with 200 mL of chloroform, the extract was dried, filtered, and concentrated under reduced pressure. The residue was dissolved in 150 mL of ethanol and acidified with hydrochloric acid; c. filtered the precipitated chloride, dried at room temperature, and recrystallized with 100 mL of absolute ethanol. Obtain 7.2 g of Sutopride Hydrochloride.

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Abstract

The invention relates to a production method of sultopride hydrochloride. The specific steps are as follows: a, dissolving 17.22g of N-ethyl-alpha-aminomethyl pyrrolidine in 360 mL of pyridine at room temperature, adding 3.51g of phosphorus trichloride, dissolving in 40mL of pyridine solution, stirring for 1 h, adding 10g of 2- methoxyl-5-ethylsulfonyl benzoic acid, and heating for refluxing for 4.5 h; b, cooling, carrying out vacuum concentration, dissolving the residue in 200mL of 20% sodium hydroxide solution, extracting with 200mL of chloroform, drying an extract, filtering, carrying out vacuum concentration, dissolving the residue in 150mLof ethanol, and acidifying with hydrochloric acid; and c, filtering the precipitated chloride, drying at room temperature, and then recrystallizing with 100mL of absolute ethyl alcohol to obtain 7.2g of sultopride hydrochloride. The production method of sultopride hydrochloride has the advantages of simple manufacture process and low production.

Description

Technical field [0001] The invention relates to the field of medicine preparation, in particular to a production method of sutopride hydrochloride. Background technique [0002] Sultopride hydrochloride is another new benzamide antipsychotic drug after sulpiride. Acts on dopamine D2 receptors and is a dopamine receptor blocker. Its sedative effect is stronger than sulpiride, and it can inhibit mania, hallucinations, delusions and psychomotor excitement. Compared with chlorpromazine, haloperidol and lithium, this product has fast action speed, strong action, and less toxic and side effects, so it has characteristics in controlling acute mental excitement. The effect on depression, anxiety and retardation is not obvious. Due to the high manufacturing cost and complexity of the current production process of Sutopride Hydrochloride. Summary of the invention [0003] The technical problem to be solved by the present invention is: in order to overcome the above-mentioned problems, a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D207/09
CPCC07D207/09
Inventor 蒋学京
Owner 蒋学京