A kind of starch hemostatic powder and its preparation method and application

Abstract

The invention discloses a starch styptic powder as well as a preparation method and an application thereof. The preparation method of the starch styptic powder comprises the following steps: with plant native starch and etherified starch as the raw materials, respectively processing the two starches through ray irradiation, performing emulsified cross-linking reaction on the two starches, extracting, washing, drying and sterilizing to obtain the product. The styptic powder has good biocompatibility, can directly act on common haemorrhage, deep haemorrhage and haemorrhage on a part which hardly can be reached through an operation and is simple and convenient to use. The starch is taken as the raw material of the styptic powder, so that the styptic powder is non-toxic and non-irritant, wide in sources, low in cost, simple and feasible in process and wide in clinical application prospect.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a starch hemostatic powder and a preparation method and application thereof. Background technique [0002] Trauma, first aid and surgical bleeding are one of the problems that need to be solved urgently. Slow and small bleeding can rely on its own mechanism to stop bleeding, but in various sudden accidents, the human body can not prevent the hidden bleeding phenomenon of arterial bleeding and organ rupture. For hemostasis, you can’t just rely on ordinary hemostatic bandages to stop bleeding. Excessive bleeding during the operation will prolong the operation time, and serious complications may occur, such as hemorrhagic shock, which may even endanger life and health. Currently, the commonly used effective hemostasis method is to use biocompatible absorbable materials to stop bleeding. It is particularly important to provide a safe, effective, easy-to-use, and low-co...

AI Technical Summary

Problems solved by technology

[0003] At present, the hemostatic materials used clinically mainly include fibrin glue, collagen, gelatin sponge and cellulose hemostatic materials. These materials have achieved good results in animal experiments and clinical applications, but there are also some shortcomings: collagen, The raw material of gelatin is derived from animal tissue, which is a heterogeneous protein, which is prone to rejection and has potential allergies. The slow absorption speed will increase the risk of wound infection; cellulose, the human body lacks the enzyme to degrade it, and the degradation time is long , may cause side effects such as infection to the patient

At present, the representative starch hemostatic material is Arista hemostatic powder produced in the United States. Although its hemostatic effect is good, it is cross-linked with epichlorohydrin, which is potentially toxic and expensive, which limits its application.