Application of gold-edge rose extract to preparation of drug for preventing chemotherapy side effects, protecting intestinal mucosal barrier and/or improving body immunity

A technique of golden-edged roses and side effects, applied in the directions of drug combinations, plant/algae/fungus/moss ingredients, pharmaceutical formulations, etc.

Inactive Publication Date: 2015-08-05
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the use of Phnom Penh rose extract in treating the side effects of chemotherapy, protecting the intestinal mucosa, and improving the body's immunity.

Method used

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  • Application of gold-edge rose extract to preparation of drug for preventing chemotherapy side effects, protecting intestinal mucosal barrier and/or improving body immunity
  • Application of gold-edge rose extract to preparation of drug for preventing chemotherapy side effects, protecting intestinal mucosal barrier and/or improving body immunity
  • Application of gold-edge rose extract to preparation of drug for preventing chemotherapy side effects, protecting intestinal mucosal barrier and/or improving body immunity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] The water extract composition of Rose Phnom Penh is composed of 100g of Rose Phnom Penh plus water for injection to 1000mL, and divided into 500 pieces. The preparation method is as follows: Weigh 100g of Rose Phnom Penh, crush it, add 1000mL of distilled water to decoct for 2 hours, repeat 3 times, combine the decoction liquid, filter, and concentrate to 100mL. Refrigerate at 4°C to precipitate impurities, filter, add sterilized water for injection to 1000mL, refrigerate overnight at 4°C, take it out, place it at room temperature, filter with suction, adjust the pH of the filtrate to 5.8-6.2 with phosphoric acid and phosphate, and then add activated carbon for decolorization , stirred at room temperature for 10 minutes, filtered, added sterile water for injection to the full amount, finely filtered with a 0.22 μm microporous membrane, potted, sterilized and subpackaged, each containing 200 mg of rose water extract.

Embodiment 2

[0048] The aqueous extract composition of Rose Phnom Penh is made of 100g of Rose Phnom Penh, 35g of starch, 75g of dextrin, 2g of magnesium stearate, 6g of talcum powder and an appropriate amount of 70% ethanol to make 1000 tablets. Preparation method: Weigh 100g of Rose Phnom Penh, crush it, add 1000mL of distilled water and decoct for 2 hours, repeat 3 times, combine the decoction liquid, filter, concentrate to extract, add auxiliary materials starch and dextrin to mix, pass through a 40-mesh sieve three times to make the mixture even . Pour an appropriate amount of 70% ethanol into the mixed powder as far as possible, mix evenly, and make a soft material, pass through a 18-20 mesh sieve to make wet granules, dry at 40-60°C, and control the moisture content of the dry granules below 1.5%. Use a 18-20 mesh sieve to granulate, mix with magnesium stearate and talcum powder, calculate the weight, measure the content, and then compress into tablets or fill capsules. Each grain (...

Embodiment 3

[0050] The alcohol extract composition of Rose Phnom Penh is composed of 100g of Rose Phnom Penh plus water for injection to 1000mL, and divided into 500 pieces. The preparation method is as follows: Weigh 100g of Rose Phnom Penh, crush it, add 1000mL of 95% ethanol to extract for 3 hours, repeat 3 times, combine the extracts, filter, concentrate until the ethanol evaporates to dryness. Refrigerate at 4°C to precipitate impurities, filter, add sterilized water for injection to 1000mL, refrigerate overnight at 4°C, take it out, place it at room temperature, filter with suction, adjust the pH of the filtrate to 5.8-6.2 with phosphoric acid and phosphate, and then add activated carbon for decolorization , stirred at room temperature for 10 minutes, filtered, added sterile water for injection to the full amount, finely filtered with a 0,22μm microporous membrane, potted, sterilized and subpackaged, each containing 200mg of rose rose extract.

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PUM

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Abstract

The invention discloses application of a gold-edge rose extract to preparation of a drug for preventing chemotherapy side effects, protecting the intestinal mucosal barrier and / or improving the body immunity. Through establishing an irinotecan hydrochloride rat chemotherapy model and respectively injecting water and alcohol extracts of a gold-edge rose as well as imodium, glutamine and interleukin-2, the water or alcohol extract of the gold-edge rose has the effects of preventing chemotherapy side effects, protecting the intestinal mucosal barrier and improving the body immunity. Therefore, the water or alcohol extract of the gold-edge rose can be used for preparing the drug for preventing chemotherapy side effects, protecting the intestinal mucosal barrier and / or improving the body immunity. The invention finds the novel application of the gold-edge rose and provides a novel drug for treating chemotherapy side effects.

Description

technical field [0001] The present invention relates to the application of Rose Phnom Penh, in particular to the application of Rose Phnom Penh extract in the preparation of drugs for resisting side effects of chemotherapy, protecting intestinal mucosal barrier and / or improving body immunity. Background technique [0002] Cancer, also known as malignant tumor, is a disease caused by the abnormal mechanism of controlling cell growth and proliferation. According to the "World Cancer Report 2014" released by WHO, the global cancer burden continues to increase. In the next 20 years, new cancer cases will reach 22 million each year, and the number of cancer deaths will rise to 13 million during the same period. It can be seen that cancer has become The number one killer affecting human health. Chemotherapy, as one of the main treatments for malignant tumors, has been widely used clinically. However, while chemotherapy drugs kill or inhibit cancer cells, they also have damage or...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/738A61P1/00A61P37/04A61P43/00
Inventor 王淇漫陶莉李志珂
Owner WUHAN UNIV
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