Binder prepared from giant salamander mucus and preparation method thereof

A giant salamander mucus and adhesive technology, which is applied in the fields of surgical adhesives, applications, medical science, etc., can solve the problems of low utilization rate, and achieve the effects of strong adhesive performance, simple preparation method, and good safety

Inactive Publication Date: 2015-08-05
CHONGQING KUIXU BIOLOGICAL SCI & TECH +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the production of giant salamander mucus is very abundant, it can be collected repeatedly in large quantities, and its utilization rate is low

Method used

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  • Binder prepared from giant salamander mucus and preparation method thereof
  • Binder prepared from giant salamander mucus and preparation method thereof
  • Binder prepared from giant salamander mucus and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The method for preparing an adhesive by utilizing giant salamander mucus comprises the following steps: placing the petri dish on which the giant salamander mucus is collected at -80°C overnight to freeze it into a solid state, and then using a vacuum freeze dryer at a vacuum degree of 19pa and a temperature of -50°C Freeze and vacuum dry for 48 hours; then mash the freeze-dried giant salamander mucus and put it in a superfine pulverizer with a temperature lower than 37°C to pulverize to 300 mesh, and finally grind it to 5×10 4 Gy dose of 60Co gamma ray irradiation sterilization to obtain tissue adhesive, aseptic packaging for future use.

Embodiment 2

[0023] The method for preparing an adhesive by using giant salamander mucus comprises the following steps: placing the petri dish on which the giant salamander mucus is collected at -20°C overnight to freeze it into a solid state, and then using a vacuum freeze dryer at a vacuum degree of 10 Pa and a temperature of -70°C Freeze and vacuum-dry for 56 hours; then mash the freeze-dried giant salamander mucus and pulverize it to 500 mesh with a superfine pulverizer with a temperature lower than 37°C, and finally grind it with 2×10 4 Gy dose of 60Co gamma ray irradiation sterilization to obtain tissue adhesive, aseptic packaging for future use.

Embodiment 3

[0025] The method for preparing an adhesive from giant salamander mucus comprises the following steps: directly placing the petri dish that collects giant salamander mucus into a vacuum drying oven, drying it under vacuum at 37°C for 48 hours, then crushing the dried giant salamander mucus and placing it at a temperature lower than 37°C. ℃ ultrafine pulverizer to 1000 mesh, and finally with 2×10 4 Gy dose of 60Co gamma ray irradiation sterilization to obtain tissue adhesive, aseptic packaging for future use.

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Abstract

The invention discloses a binder prepared from giant salamander mucus and a preparation method thereof. The binder is freeze-dried powder of giant salamander mucus. The preparation method comprises the following steps of freezing giant salamander mucus to obtain solids, carrying out refrigeration vacuum drying to remove water, crushing the dried giant salamander mucus and carrying out disinfection. The preparation method has simple processes. The binder has good viscidity and can be directly used as a tissue binder for operation wound bonding and bone bonding. The binder is prepared from giant salamander, contains pure natural components, has good safety and biocompatibility, can be degraded and has a wide application prospect.

Description

technical field [0001] The invention belongs to the field of biological materials, and in particular relates to an adhesive prepared from giant salamander mucus and a preparation method of the adhesive. Background technique [0002] The giant salamander, commonly known as the giant salamander, belongs to the family Cryptogillidae of the order Amphibians, and includes 2 genera and 3 species, namely the genus Giant salamander and the genus Cryptogill. Among them, the genus Giant salamander can be divided into the Japanese giant salamander and the Chinese giant salamander. It is the largest and most precious in the world. Amphibians have been included in the endangered species protection list by the United Nations, and they are national second-class protected aquatic wild animals. Giant salamander meat is tender and delicious, contains high-quality protein, rich in amino acids and trace elements, and has extremely high nutritional value. It is known as "ginseng in water" and "s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/00
Inventor 商海涛王莹陈兵苟强魏泓邢孟秋周明辉
Owner CHONGQING KUIXU BIOLOGICAL SCI & TECH
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