Application of total triterpenoids of Pteridocarpus in protecting acute alcoholic liver injury

A technology for alcohol liver damage and total triterpenes, applied in the field of biomedicine, can solve the problems of less research on the chemical components of Viburnum fern and its pharmacology and mechanism, achieve considerable development and application value, and have no toxic and side effects

Active Publication Date: 2017-06-27
SHAANXI NORMAL UNIV
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AI Technical Summary

Problems solved by technology

Up to now, there are few studies on the chemical constituents of Viburnum viburnum and their pharmacology and mechanism

Method used

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  • Application of total triterpenoids of Pteridocarpus in protecting acute alcoholic liver injury
  • Application of total triterpenoids of Pteridocarpus in protecting acute alcoholic liver injury
  • Application of total triterpenoids of Pteridocarpus in protecting acute alcoholic liver injury

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Embodiment Construction

[0022] The present invention will be further described in detail below in conjunction with specific embodiments, which are explanations of the present invention rather than limitations.

[0023] 1. Experimental materials

[0024] The pod fern was collected from Xunyangba Town, Ningshan County, Shaanxi Province, and was identified as Matteucciastruthiopteris of the Onocleaceae (Onocleaceae) genus Matteuccia Todaro by Associate Professor Ma Ji, School of Life Sciences, Shaanxi Normal University; the male Kunming species is small 70 mice (body weight 18±2g) were provided by Animal Experiment Center of Fourth Military Medical University.

[0025] Experimental reagents: absolute ethanol, xylene, sodium chloride, and hydrochloric acid were purchased from Tianjin Tianli Chemical Reagent Co., Ltd.; paraformaldehyde, hematoxylin, sectioned paraffin, bifendate, neutral gum, and eosin were purchased from Beijing Chemical Reagent Company; medical alanine aminotransferase (GPT), aspartate...

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Abstract

The invention discloses the application of the total triterpenoids of fern fern to protect acute alcoholic liver injury, and belongs to the technical field of biomedicine. The present invention adopts the method of drinking a large amount of alcohol once by mouth to build the model, and the biochemical indicators of GOT and GPT show that the total triterpenoids of Pteridocarpus can inhibit GOT and GPT to a certain extent, and the inhibitory effect is positively correlated with the dosage. The biochemical indicators of MDA and SOD indicate that the protective mechanism of the purified total triterpenoids of Viburnum viburnum against alcohol-induced acute liver injury may be related to its antioxidant capacity. Free radicals, thereby playing a role in alleviating alcoholic liver damage. The purified total triterpenoids of Viburnum can effectively alleviate the oxidative damage caused by lipid peroxidation and free radical attack in the liver, reduce the degree of hepatocyte enlargement, necrosis and fatty degeneration, and regulate the recovery of normal metabolism and physiological functions of cells, indicating that The total triterpenoids of Pteridocarpus have a certain protective effect on acute alcoholic liver injury.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the application of total triterpenoids of Pteridocarpus to protect acute alcoholic liver injury. Background technique [0002] At present, liver disease has become one of the diseases that generally plague human health all over the world. Liver injury refers to the invasion of the liver by external factors, resulting in damage to its structure and function. According to the different causes of liver damage, it can be roughly divided into three types: drug-induced hepatitis, alcoholic hepatitis and viral hepatitis. [0003] Alcoholic Liver Disease (ALD) refers to a series of diseases such as liver damage caused by excessive intake of alcohol. The Liver Branch of the Chinese Medical Association has established pathological diagnostic criteria for ALD based on the degree of lesions, and is generally divided into five types according to histology: mild alcoholic liv...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/11A61P1/16A23L33/00
Inventor 马骥杨晓艳张贵凤
Owner SHAANXI NORMAL UNIV
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