Novel propolis soft capsule and preparation method thereof

A soft capsule, propolis technology, applied in pharmaceutical formulations, medical preparations containing active ingredients, metabolic diseases, etc., can solve problems such as decreased insulin receptor sensitivity, liver toxicity, and disease aggravation, and achieves no solvent residue, High degree of purification, the effect of solving waste

Inactive Publication Date: 2015-09-02
JIANGSU JIANGDAYUAN ECOLOGICAL BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these drugs have more or less adverse side effects on the human body. For example, long-term use of insulin will lead to a decrease in the sensitivity of the body’s insulin receptors, resulting in insulin resistance, and the inability to effectively use insulin, which will eventually aggravate the condition.
The monotony of sulfonylureas and biguanides and their toxic effects on the liver make them unfavorable for use in middle-aged and elderly patients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] A kind of preparation method of novel propolis soft capsule, its method step is as follows:

[0020] A. According to the requirements of parts by weight, weigh each component material: propolis supercritical CO 2 29 parts of extract, 22 parts of Ganoderma lucidum spore oil, 44 parts of wheat germ oil, 22 parts of corn oil; 15 parts of vitamin E, 15 parts of beeswax; 85 parts of gelatin, 55 parts of glycerin, 100 parts of purified water.

[0021] B. Propolis supercritical CO 2 Preparation of extract: using simulated biological fluidized bed supercritical CO 2 The method of fluid extraction of propolis (ZL200910030879.3) extracts propolis to obtain propolis supercritical CO 2 extract, spare;

[0022] C, the preparation of mixed oil agent: 22 parts of ganoderma lucidum spore oils are mixed with 22 parts of wheat germ oils, and rotating speed is 45r / min when mixing, and mixing temperature is 88 degree, gets the first mixed oil agent; With 22 parts of corn oils and 22 pa...

Embodiment 2

[0028] A kind of preparation method of novel propolis soft capsule, its method step is as follows:

[0029] A. According to the required range of parts by weight, weigh each component material: propolis supercritical CO 2 Extract 25 parts, Ganoderma lucidum spore oil 33 parts, wheat germ oil 44 parts, vitamin E 13 parts, beeswax 12 parts; gelatin 75 parts, glycerin 49 parts, purified water 88 parts.

[0030] B. Propolis supercritical CO 2 Preparation of extract: using simulated biological fluidized bed supercritical CO 2 The method of fluid extraction of propolis (ZL200910030879.3) extracts propolis to obtain propolis supercritical CO 2 extract, spare;

[0031] C, the preparation of mixed oil preparation: mix Ganoderma lucidum spore oil and wheat germ oil evenly, the rotating speed during mixing is 45r / min, and mixing temperature is 120 degrees; After mixing is finished, filter with 400 mesh filter screen, get mixed oil preparation;

[0032] D. Preparation of capsule conte...

Embodiment 3

[0036] A kind of preparation method of novel propolis soft capsule, its method step is as follows:

[0037] A. According to the required range of parts by weight, weigh each component material: propolis supercritical CO 2 Extract 35 parts, wheat germ oil 50 parts, corn oil 45 parts, vitamin E 25 parts, beeswax 24 parts; gelatin 95 parts, glycerin 65 parts, purified water 105 parts.

[0038] B. Propolis supercritical CO 2 Preparation of extract: using simulated biological fluidized bed supercritical CO 2 The method of fluid extraction of propolis (ZL200910030879.3) extracts propolis to obtain propolis supercritical CO 2 extract, spare;

[0039] C, the preparation of mixed oil agent: mix wheat germ oil and corn oil evenly, the rotating speed during mixing is 45r / min, and mixing temperature is 120 degree; After mixing is finished, filter with 400 mesh filter screen, get mixed oil agent;

[0040] D. Preparation of capsule contents: Pour the mixed oil into a vacuum emulsifier a...

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PUM

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Abstract

The invention discloses a novel propolis soft capsule which comprises a capsule content and a capsule shell, wherein the capsule content consists of the following components in parts by weight: 25-35 parts of a propolis supercritical CO2 extract, 77-95 parts of a mixed oil agent, 13-25 parts of vitamin E and 12-24 parts of beeswax; and the capsule shell consists of the following components in parts by weight: 75-95 parts of gelatin, 49-65 parts of glycerol and 88-105 parts of purified water. The propolis, which is extracted through supercritical carbon dioxide, is higher in purity; some components low in boiling point are reserved, and the soft capsule is free from solvent residue, safe, non-toxic and reliable; and by virtue of a soft capsule preparation process of covering the content with a glue solution, the waste of the content is avoided.

Description

technical field [0001] The invention relates to a preparation method of a soft capsule, in particular to a novel propolis soft capsule and a preparation method thereof. Background technique [0002] Diabetes is a lifelong disease that is ravaging the world. The incidence rate in the world is increasing year by year, and it has been listed as the third largest disease after cardiovascular disease and tumor. The prevalence of diabetes in my country is 3.2%, and the total number has increased nearly five times in the past 20 years. At present, the greatest hazard of diabetes to human health is the various chronic complications based on arteriosclerosis and microvascular disease, such as diabetic heart disease, diabetic gangrene, diabetic cerebrovascular disease, diabetic nephropathy, diabetic retina disease and neuropathy. The number of blindness caused by diabetes is 10-25 times more than the average person, the number of diabetic gangrene and amputation is 20 times more th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/644A61P3/10A61P9/00A61P9/10A61P13/12A61P25/00A61P17/02A61K31/355
Inventor 朱惠芬邵兴军毛日文
Owner JIANGSU JIANGDAYUAN ECOLOGICAL BIOLOGICAL TECH
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