Solid preparation containing omeprazole and preparation method thereof

A technology for omeprazole and solid preparation, applied in the field of solid preparation containing omeprazole and preparation thereof, can solve the problems of low bioavailability, cumbersome preparation process, many times of taking by patients, etc. The process is simple and the effect of delaying the retention time in the stomach

Active Publication Date: 2015-09-09
SHANGHAI SINE WANXIANG PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The invention provides a solid preparation containing omeprazole and a preparation method thereof, which are used to solve the problems of many times of taking by patients, low bioavailability and cumbersome preparation process in the prior art

Method used

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  • Solid preparation containing omeprazole and preparation method thereof
  • Solid preparation containing omeprazole and preparation method thereof
  • Solid preparation containing omeprazole and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Example 1 is made of the following parts by weight of raw materials:

[0055] Omeprazole raw material coating prescription (1000 tablets)

[0056] Omeprazole 20g

[0057] Coating liquid for isolation layer:

[0058]

[0059] Enteric layer coating liquid:

[0060]

[0061] Tableting prescription (1000 tablets):

[0062]

[0063]

[0064] The preparation of the above solid preparation containing omeprazole specifically includes the following steps:

[0065] (1) Preparation of omeprazole coated granules:

[0066] Step 101: Pass the prescription amount of omeprazole through a 45-mesh sieve, put it in a boiling coating machine, and turn it on for heating;

[0067] Step 102, prepare the isolation layer coating solution according to the prescription;

[0068] Step 103: When the material temperature in the boiling coater reaches 35°C, start spraying the isolation layer coating solution prepared in step 201, and control the material temperature below 40°C during the entire coating process unti...

Embodiment 2-7

[0077] Table 1 Example 2-7 Tabletting Recipe

[0078]

[0079]

[0080] The specific preparation method is the same as in Example 1, and the omeprazole solid preparation of the present invention is also obtained in the same manner as in Example 1. Among them, the dosages of omeprazole, amoxicillin, and potassium bismuth citrate per 1000 tablets of solid preparations containing omeprazole were 20 mg, 250 mg, and 150 mg, respectively. The omeprazole-coated granules in Examples 1-7 were prepared using the above-mentioned coating formulation, and the coating auxiliary materials were all commercially available. The omeprazole used Zhejiang Jinhua Kangenbei Biopharmaceutical Co., Ltd. product, amoxicillin The products of North China Pharmaceutical Group Xiantai Pharmaceutical Co., Ltd. and the products of Wuhan Dahua Weiye Pharmaceutical and Chemical (Group) Co., Ltd. are used for bismuth potassium citrate. Other coating materials are commercially available.

[0081] Investigation of re...

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Abstract

The invention relates to the field of pharmaceutical preparations used for treating stomach ulcers, and discloses a solid preparation containing omeprazole. The preparation comprises main drug components including omeprazole, amoxicillin and bismuth potassium citrate, and omeprazole-coated particles are prepared through the main drug omeprazole and coating excipient powder. The solid preparation comprises, by weight, 10-17% of the omeprazole-coated particles, 29-37% of the amoxicillin, 16-24% of the bismuth potassium citrate, 7-12% of matrix materials, 5-8% of foaming agents, 13-21% of rate regulators and 0.5-1.5% of lubricants, wherein the sum of content percentage of all the components is equal to 100%. According to the solid preparation, the three main drugs are prepared into the compound preparation. The powder coating technology is adopted, patient compliance is improved, the medicine taking frequency is reduced, and bioavailability of the drugs is improved.

Description

Technical field [0001] The invention relates to the field of medicinal preparations for treating gastric ulcer, in particular to a solid preparation containing omeprazole and a preparation method thereof. Background technique [0002] Among the many anti-peptic ulcer drugs at present, H2 receptor antagonists and proton pump inhibitors dominate the clinic. They all rapidly improve various symptoms caused by ulcers by powerfully inhibiting gastric acid secretion. It is fast, so it is easy to cause the problems of uneven tissue repair and easy recurrence of ulcers. The recurrence rate within one year after ulcer healing is as high as 60-80%. [0003] Triple therapy is currently a popular method for treating gastric ulcers. At present, patients have to take three single preparations at the same time, which increases the number of medications, which is extremely inconvenient, and the existing drugs have a short residence time in the stomach, low drug bioavailability, and patient adaptab...

Claims

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Application Information

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IPC IPC(8): A61K31/4439A61K9/20A61K47/38A61K47/36A61K47/34A61K47/32A61P1/04A61K31/43A61K31/194
Inventor 郭晶晶常艳玲顾煜董佳丽史红王平
Owner SHANGHAI SINE WANXIANG PHARMA
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