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Production method for compound fluocinonide tincture and prepared compound fluocinonide tincture

A technology of fluocinolone acetate and a production method, which is applied in the field of medicine, can solve the problems of reducing the content of the main drug, can not effectively solve the problem of reducing the content of the main drug, and achieves the effect of reducing the degree of hydrolysis and solving the reduction of the content of the main drug

Active Publication Date: 2015-09-30
INNER MONGOLIA DATANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, the stability test was carried out by adding antioxidants (such as vitamin C, cysteine ​​hydrochloride, sodium dithionite, sodium thiosulfate and sodium bisulfite, etc.) reduce
[0008] Therefore, related technology can not effectively solve the problem that the content of principal medicine drops

Method used

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  • Production method for compound fluocinonide tincture and prepared compound fluocinonide tincture
  • Production method for compound fluocinonide tincture and prepared compound fluocinonide tincture
  • Production method for compound fluocinonide tincture and prepared compound fluocinonide tincture

Examples

Experimental program
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Effect test

preparation example 1

[0062] Prepare compound fluocinolone acetate tincture as follows,

[0063] Add 790ml of ethanol to the liquid mixing tank, start the stirring paddle of the liquid mixing tank, add 50g of salicylic acid and stir to dissolve, then add 50ml of glycerin, resorcinol 100g, borneol 20g, stir and dissolve to obtain the first mixed solution. Make the first mixed solution pass through a water-absorbing column containing 200g of silica gel (the quality of silica gel is 23.35% of the mass of the first mixed solution), weigh 0.4g of fluocinolone acetate and dissolve it in 20ml dimethyl sulfoxide, and dissolve to obtain the second mixed solution. liquid. Add the second mixture to the first mixture passing through the absorbent column. Adjust to the specified amount with an appropriate amount of absolute ethanol, continue to stir, and obtain it.

preparation example 2

[0065] Prepare compound fluocinolone acetate tincture as follows,

[0066] Add 79L of ethanol to the liquid mixing tank, start the stirring paddle of the liquid mixing tank, add 5kg of salicylic acid and stir to dissolve, then add 5L of glycerin, 10kg of resorcinol, and 2kg of borneol successively, stir and dissolve to obtain the first mixed solution. Make the first mixed solution pass through a water-absorbing column containing 6kg molecular sieve (molecular sieve mass is 7.01% of the first mixed solution mass), then weigh 40 g of fluocinolone acetate and dissolve it in 2L dimethyl sulfoxide, and dissolve to obtain the second mixed solution . Add the second mixture to the first mixture passing through the absorbent column. Adjust to the specified amount with an appropriate amount of absolute ethanol, continue to stir, and obtain it.

preparation example 3

[0068] Prepare compound fluocinolone acetate tincture as follows,

[0069] Add 553L ethanol in the liquid mixing tank, start the liquid mixing tank stirring paddle, add 35kg salicylic acid and stir to dissolve, then add 35L glycerin, resorcinol 70kg, borneol 14kg successively, stir, dissolve, get the first mixed solution. Make the first mixed solution pass through the water absorption column containing 30kg fiber desiccant (the quality of fiber desiccant is 6.53% of the first mixed solution quality), then weigh fluocinolone acetate 0.28kg and be dissolved in 14L dimethyl sulfoxide, dissolve, Obtain the second mixture. Add the second mixture to the first mixture passing through the absorbent column. Adjust to the specified amount with an appropriate amount of absolute ethanol, continue to stir, and obtain it.

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Abstract

The invention relates to the field of medicine, in particular to a production method for compound fluocinonide tincture. The method comprises the steps that 1, first mixed liquor containing ethyl alcohol, salicylic acid, glycerol, resorcinol and borneol and second mixed liquor containing fluocinonide and dimethyl sulfoxide are prepared; 2, water in the first mixed liquor is removed; 3, the second mixed liquor is mixed with the first liquor with the water removed. The compound fluocinonide tincture is prepared through the production method. According to the production method for the compound fluocinonide tincture, the water contained in raw materials such as ethyl alcohol, salicylic acid, glycerol, resorcinol and borneol can be removed, the prepared compound fluocinonide tincture does not contain water basically, the hydrolysis degree of the chief herb fluocinonide is greatly reduced, and therefore the problem that the content of a chief herb in the compound fluocinonide tincture is reduced can be effectively solved.

Description

technical field [0001] The application relates to the field of medicine, in particular to a production method of compound fluocinolone acetate tincture. Background technique [0002] Fluocinolone acetate, chemical name: 11β-hydroxy-16α,17-[(1-methylethylene)-bis(oxygen)]-21-(acetyloxy)-6,9-difluoropregna-1 ,4-diene-3,20-dione, its structure is as follows: [0003] [0004] Fluocinonide acetate is generally used for external use for skin diseases that are effective to glucocorticoids, such as contact dermatitis, atopic dermatitis, seborrheic dermatitis, eczema, pruritus, psoriasis, neurodermatitis and other pruritic and non-infectious Sexual inflammatory skin disease. [0005] At present, fluocinonide acetate is prepared into various external dosage forms at home and abroad, such as fluocinonide acetate cream, fluocinonide acetate ointment and compound fluocinonide acetate tincture, etc., especially the compound fluocinonide acetate tincture, Piyanning tincture, which is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/58A61K47/04A61K47/02A61K47/46A61P17/00A61P17/04A61P17/06
Inventor 赵粉荣
Owner INNER MONGOLIA DATANG PHARMA
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