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A structure-controllable brush-type multi-quaternary ammonium salt antibacterial agent and its preparation method

A technology of multiple quaternary ammonium salts and antibacterial agents, applied in the field of quaternary ammonium salt antibacterial agents, can solve the problems of complex preparation methods of antibacterial agents, and achieve good water solubility, prevent bacterial growth, and good antibacterial properties

Active Publication Date: 2017-04-19
GUANGZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention proposes a method for preparing a multi-quaternary ammonium salt antibacterial agent with controllable structure, which overcomes the complicated problem of antibacterial agent preparation methods in the prior art

Method used

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  • A structure-controllable brush-type multi-quaternary ammonium salt antibacterial agent and its preparation method
  • A structure-controllable brush-type multi-quaternary ammonium salt antibacterial agent and its preparation method
  • A structure-controllable brush-type multi-quaternary ammonium salt antibacterial agent and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Add 40.0g (0.095 mole) AG80 and 60g (0.57 mole) diethanolamine into a 250ml round bottom flask, and at a reaction temperature of 90°C, the reaction time is 5h to obtain the first step product - modified AG80, after decompression Distillation and vacuum oven drying to obtain pure modified AG80;

[0025] Take 5.6g (0.0066 moles) of modified AG80 and add 10g (0.08 moles) of benzyl chloride, and react dropwise at 80°C for 12 hours to obtain the final product brush-shaped structure multi-quaternary ammonium salt antibacterial agent, which is subjected to vacuum distillation, drying, etc. After the procedure, pure brush-shaped structure polyquaternary ammonium salt antibacterial agent S-1 is obtained, and its degree of quaternization is 98.9%.

Embodiment 2

[0027] Add 40.0g (0.095 mole) AG80 and 60g (0.57 mole) diethanolamine into a 250ml round bottom flask, and at a reaction temperature of 80°C, the reaction time is 4h to obtain the first step product - modified AG80, after decompression Distillation and vacuum oven drying to obtain pure modified AG80;

[0028] Take 11g (0.013 moles) of modified AG80 and add 10g (0.08 moles) of benzyl chloride, and react dropwise at 90°C for 14 hours to obtain the final product-brush-shaped structure multi-quaternary ammonium salt antibacterial agent, which is subjected to vacuum distillation and drying. Obtain pure brush-type structure polyquaternary ammonium salt antibacterial agent S-2 after the procedure, and its degree of quaternization is 80.5%.

Embodiment 3

[0030] Add 40.0g (0.095 mole) AG80 and 60g (0.57 mole) diethanolamine into a 250ml round bottom flask, and at a reaction temperature of 100°C, the reaction time is 7h to obtain the first step product - modified AG80, after decompression Distillation and vacuum oven drying to obtain pure modified AG80;

[0031] Take 14g (0.017 moles) of modified AG80 and add 10g (0.08 moles) of benzyl chloride, and react dropwise at 95°C for 13 hours to obtain the final product-a multi-quaternary ammonium antibacterial agent with a brush structure, which is distilled under reduced pressure, dried, etc. After the procedure, pure brush-type structure polyquaternary ammonium salt antibacterial agent S-3 is obtained. Its degree of quaternization is 63.8%.

[0032] The multi-quaternary ammonium salt antibacterial agents with brush structure prepared by the above method all have good water solubility.

[0033] The molecular structure of the modified AG80 obtained in the above embodiment 1 and the m...

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Abstract

The present invention proposes a structure-controllable multi-quaternary ammonium antibacterial agent with a brush structure, the structural formula of which is: R1 is N or R2 is N or R3 is N or R4 is N or R5 is N or R6 is N or And at least one of R1, R2, R3, R4, R5, and R6 is the multi-quaternary ammonium salt antibacterial agent with controllable structure and brush structure of the present invention, which has controllable structure, good antibacterial properties and certain builder properties. There are multiple quaternary ammonium salt cations in the structure, and its cation charge density can be controlled by adjusting the ratio of reaction raw materials. It can exhibit high-density positive charge, which can strongly adsorb or adsorb more negatively charged bacteria, destroying Bacterial cell structure prevents bacterial growth and achieves high bactericidal properties. The invention also proposes a controllable brush structure multi-quaternary ammonium salt antibacterial agent, which has a simple preparation method.

Description

technical field [0001] The invention relates to a quaternary ammonium salt antibacterial agent, in particular to a structure-controllable brush-type multi-quaternary ammonium antibacterial agent. The present invention also relates to a structure-controllable brush-type structure multi-quaternary ammonium antibacterial agent. Preparation. Background technique [0002] Antimicrobial agents are a type of preparation that are often added to other materials to increase the material's ability to inhibit or kill microorganisms such as bacteria. Conventional antibacterial agents can be divided into inorganic, organic and compound antibacterial agents. Inorganic antibacterial agents have the disadvantages of high price, easy dissolution, and poor durability; the research on compound antibacterial agents has just started in China, and the preparation method is relatively complicated; organic antibacterial agents, such as natural organic antibacterial agents, have relatively low heat ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N33/12A01P1/00C07C213/02C07C215/40
Inventor 林璟周俏婷李丽华吕宛孺何倩莹陈晓红
Owner GUANGZHOU UNIVERSITY
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