Application of compound Hu-17 alone or in combination with platinum drugs in preparing drugs for treating ovarian cancer

A compound and ovarian cancer technology, applied in the field of medicine and biology, can solve the problems of injury, insensitivity to treatment methods, weakening the efficacy of chemotherapy, etc., and achieve the effect of high feasibility, great social significance and application value, and clear mechanism of drug effect.

Active Publication Date: 2015-10-07
RENJI HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The mechanism of action of platinum drugs (cisplatin or carboplatin) to eliminate ovarian cancer cells is mainly through molecules such as P53 and JNK. Clinical data show that about 60%-80% of ovarian cancer patients contain mutations or deletions of the P53 gene. The mutation or deletion of this gene directly weakens the efficacy of platinum-based chemotherapy; in addition, about 30% of ovarian cancer patients are not sensitive to the combination of platinum-based drugs and paclitaxel; Within the effective dose range, it can cause greater damage to the body, such as strong nephrotoxicity and ototoxicity caused by cisplatin

Method used

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  • Application of compound Hu-17 alone or in combination with platinum drugs in preparing drugs for treating ovarian cancer
  • Application of compound Hu-17 alone or in combination with platinum drugs in preparing drugs for treating ovarian cancer
  • Application of compound Hu-17 alone or in combination with platinum drugs in preparing drugs for treating ovarian cancer

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1. Preparation of compound Hu-17

[0038] The chemical structural formula of compound Hu-17 is as follows:

[0039]

[0040] Molecular formula: C 63 h 96 N 4 o 11 , Molecular weight: 1084Da.

[0041] Phytolaccagenin (phytolaccagenin) is a kind of active ingredient separated from the traditional Chinese medicine Pokweed, and it is the aglycone part of Phytolacca saponin A (Esculentoside A, EsA), and Phytolaccagenin in the present invention is obtained through acid hydrolysis. Obtained from saponin A, its structure is as follows:

[0042]

[0043] Dissolve pokeweed saponin (26.6mg, 0.05mmol) in dry 2ml DMF / THF (1:3, v / v), add N,N-dicyclohexylcarboimide (DCC, 20.7mg, 0.1 mmol) and N-hydroxybenzotriazole (HOBt, 13.5 mg, 0.1 mmol), stirred at room temperature for 3 hours. After the completion of the reaction, concentrate under reduced pressure to dryness, dissolve the residue with dichloromethane (20ml), filter, and concentrate the filtrate to dryness...

Embodiment 2

[0044] Example 2. The application of compound Hu-17 alone or in combination with platinum drugs in the preparation of drugs for the treatment of ovarian cancer

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PUM

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Abstract

The invention discloses an application of a compound Hu-17 alone or in combination with platinum drugs in preparing drugs for treating ovarian cancer and provides a new treatment protocol for patients with ovarian cancer, especially for those who relapse due to drug resistance. By adopting the treatment protocol, drug resistance of the patients carrying a P53 mutation or having P53 deletion to platinum drugs can be overcome. The pharmacologic mechanism is clear, implementation feasibility is high, and the application on which new hopes of curing patients who have ovarian cancer and relapse due to drug resistance will arise has great social significance and application value.

Description

technical field [0001] The invention belongs to the field of medicine and biology, and more specifically, the invention relates to the application of compound Hu-17 alone or in combination with platinum drugs in the preparation of drugs for treating ovarian cancer. Background technique [0002] Ovarian cancer is a malignant tumor that seriously threatens women's health. Its incidence rate ranks third among gynecological malignancies, and its mortality rate ranks first among gynecological malignancies (Agarwal R, Kaye SB. Nat Rev Cancer, 2003, 3(7): 502-516.). The occurrence of ovarian cancer is also closely related to hormone levels. Although the treatment of ovarian cancer has been greatly improved in the past two decades, its current 5-year survival rate still does not exceed 30% (Bast RC, Hennessy B, Mills GB. Nature Reviews Cancer, 2009, 9 (6): 415- 428.). The clinical treatment of ovarian cancer is a comprehensive treatment method of surgical resection and adjuvant c...

Claims

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Application Information

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IPC IPC(8): A61K31/58A61K33/14A61K31/282A61P35/00
Inventor 杜艳芝刘建胜易杨华陈子江
Owner RENJI HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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