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Medicine-carrying type elastomer wound dressing containing halloysite nanotube and preparation method of wound dressing

A technology of halloysite nanotubes and wound dressings, which is applied in medical science, bandages, absorbent pads, etc., and can solve problems such as bacterial infection and secondary trauma

Active Publication Date: 2015-10-14
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, when it is used, the wound granulation tissue grows into the dressing and causes adhesion; when it is removed, it is easy to cause secondary trauma; it is easy to cause bacterial infection due to wound area fluid

Method used

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  • Medicine-carrying type elastomer wound dressing containing halloysite nanotube and preparation method of wound dressing
  • Medicine-carrying type elastomer wound dressing containing halloysite nanotube and preparation method of wound dressing
  • Medicine-carrying type elastomer wound dressing containing halloysite nanotube and preparation method of wound dressing

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0038] Example 1: 100:50:5:1

[0039] (1) Add 32.05g of gelatin and 16.03g of water into the reaction flask, stir and put into a vacuum oven, set the temperature to 70°C, after reacting for 7 days, take out the required uniform elastomeric raw rubber.

[0040] (2) Weigh 2g of halloysite nanotubes into a three-necked flask and add 20ml of toluene reagent. Fill the three-necked flask with nitrogen. Set the temperature of the oil bath to 120℃. After the temperature rises to 120℃, put it into the three-necked flask. Continue to add 4ml of 3-aminopropyltriethoxysilane for modification reaction, take out the toluene solution of halloysite nanotubes after 24h reaction. Centrifuge the toluene solution containing halloysite nanotubes, and after centrifugation 5 times, the modified halloysite nanotubes are dried and ground.

[0041] (3) Weigh 2 g of antibacterial drug polymyxin sulfate B into deionized water, fully stir to dissolve and obtain a saturated solution of polymyxin sulfate B.

[004...

example 2

[0045] Example 2: 100:1000:50:50

[0046] (1) Add 4.17 g of gelatin and 41.67 g of glycerin to the reaction flask, put them in a vacuum oven after stirring, and set the temperature to 50° C. After reacting for 2 days, take out the desired uniform elastomeric raw rubber.

[0047] (2) Weigh 2.5g of halloysite nanotubes into a three-necked flask and add 30ml of toluene reagent. Fill the three-necked flask with nitrogen. Set the temperature of the oil bath to 120℃. After the temperature rises to 120℃, transfer it to the three-necked flask. Continue to add 5ml of 3-aminopropyltriethoxysilane to the mixture for modification reaction, and take out the toluene solution of halloysite nanotubes after 24h reaction. Centrifuge the toluene solution containing halloysite nanotubes, and after centrifugation 5 times, the modified halloysite nanotubes are dried and ground.

[0048] (3) Weigh 2.5 g of the antibacterial drug cephalosporin and add it to deionized water, fully stir to dissolve and obtai...

example 3

[0052] Example 3: 100:100:15:10

[0053] (1) Add 22.22g of sodium alginate, 11.11g of glycerol and 11.11g of deionized water into the reaction flask, stir and put it into a vacuum oven, set the temperature to 60℃, after reacting for 5 days, take it out to obtain the desired uniformity The elastomer raw rubber.

[0054] (2) Weigh 4g of halloysite nanotubes into a three-necked flask and add 40ml of toluene reagent. Fill the three-necked flask with nitrogen. Set the temperature of the oil bath to 120℃. After the temperature rises to 120℃, put it into the three-necked flask. Continue to add 8ml 3-aminopropyltriethoxysilane for modification reaction, take out the toluene solution of halloysite nanotubes after 24h reaction. Centrifuge the toluene solution containing halloysite nanotubes, and after centrifugation 5 times, the modified halloysite nanotubes are dried and ground.

[0055] (3) Weigh 4 g of the antibacterial drug tetracycline hydrochloride and add it to deionized water, fully ...

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Abstract

The invention relates to medicine-carrying type elastomer wound dressing containing a halloysite nanotube and a preparation method of the wound dressing. According to the wound dressing and the preparation method of the wound dressing, biodegradable natural polymers are taken as a substrate, an antibacterial drug and a halloysite nanotube loaded with an antibacterial drug (the same as or different from the abovementioned antibacterial drug) are added, and elastomer biological films with different biological activities are prepared through hot melting and blending; the raw materials are low in cost, have excellent biological properties and biodegradability, and can promote regeneration and repair of tissue, the release of the medicines can inhibit bacterial infection and inflammation which are easily generated, and the technology can be widely applied to scaffolds, artificial internal organs, wound dressing, fixed point release films of medicines and blood storage bags in tissue engineering, and the field of medical treatment and public health, including and medical catheters and the like.

Description

Technical field: [0001] The invention belongs to the field of biopolymer materials, and in particular relates to a wound dressing elastomer biofilm that uses degradable natural polymer materials as a matrix material and adds antibacterial drugs and halloysite nanotubes loaded with antibacterial drugs and a preparation method thereof . Background technique: [0002] The skin is a barrier to contact with the external environment. It is easy to be injured or damaged due to diseases. This will cause the loss of moisture, electrolytes and proteins in the wound. An open wound also increases the chance of infection. [0003] In order to slow down the occurrence of the above symptoms, dressings are generally used to cover and protect the wound and provide an environment conducive to wound healing. For a long time, the most commonly used surgical wound dressings are medical absorbent cotton and gauze. It can play a certain role in promoting the treatment of trauma, but it has great shortc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/20A61L15/22A61L15/32A61L15/28A61L15/44
Inventor 张立群牛玉昭薛佳佳廖美红
Owner BEIJING UNIV OF CHEM TECH
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