Substituted tetrahydroquinoline derivative, hydrolysis product thereof, synthetic method and application thereof

Abstract

The invention provides a substituted tetrahydroquinoline derivative and a hydrolysis product thereof, and provides a method of preparing the above-mentioned compound with visible-light-responding surface-modified titanium dioxide catalyst and an application of the tetrahydroquinoline derivative and the hydrolysis product thereof in the fields of antibacterial medicines. The compound in the invention is wide in anti-bacterial activity, is prepared with the surface-modified titanium dioxide, which is low in cost and easy to obtain and is stable and toxic-free, as the catalyst, so that the tetrahydroquinoline compound can be synthesized with visible light, is green in reactions and is environment-friendly. In addition, by means of introduction of other active groups into a tetrahydroquinoline ring, new tetrahydroquinoline derivative having the anti-bacterial activity can be prepared.

Description

technical field

[0001] The invention belongs to the field of medicinal chemistry and relates to a substituted tetrahydroquinoline derivative, in particular to a preparation method for visible light catalytic synthesis of a substituted tetrahydroquinoline derivative based on modified P25. Background technique

[0002] In recent years, visible-light-induced photoredox catalysis has attracted extensive attention as an efficient and versatile method for the functionalization of relatively inactive C–H in the nitrogen neighbourhood. Commonly used visible light catalysts are complexes of Ru and Ir and organic dyes. However, compared with homogeneous catalysts, these catalysts have many disadvantages, such as expensive, and cannot be recycled and reused.

[0003] Titanium dioxide (P25) as a highly efficient photocatalyst has received extensive attention in recent years, but the absorption of P25 in the visible light region is very weak, and its catalysis is mainly carried out under...

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